William D. Hardie, MD
Appointment
Associate Professor, Pulmonary Medicine
Email
william.hardie@chmcc.org
Phone
513-636-6771
Fax
513-636-4615
Credentials
MD: Vanderbilt University, Nashville, Tenn., 1990.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio.
Fellowship: Pediatric Pulmonary, Children's Hospital Medical Center, Cincinnati, Ohio.
Certification: Pediatrics, 1993; Pulmonary Medicine, 1999.
Position History
- 1988-89 American Heart Association Medical Student Research Fellowship. Department of Pulmonary Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
- 1990-93 Internship and Residency - Cincinnati Children's Hospital Medical Center
- 1993-96 Pediatric Pulmonary Fellowship - Cincinnati Children's Hospital Medical Center
- 1996-1998 Instructor, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center
- 1997-present Director, Pulmonary Function Laboratory, Cincinnati Children's Hospital Medical Center
- 1998 - 2003 Assistant Professor of Clinical Pediatrics, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center
- 2003-present Associate Professor of Clinical Pediatrics, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center
Awards and Honors
- 1989 Alpha Omega Alpha Research Award
- 1992 Resident Teaching Award
- 1993 Samuel Dalinsky Award ("Outstanding Graduating Resident")
- 2000 Mead Johnson Excellence in Teaching Commendation Recipient
- 2000 Mead Johnson Excellence in Teaching Award
- 2008 Best Doctors in America
Research
Growth factors in lung remodeling.
Research Grants and Contracts
University of Cincinnati Center for Environmental Genetics
Dates: 04/01/04-3/31/05
Title: Mechanism of Protection from Nickel-Induced Lung Injury by Transforming Growth Factor Alpha Expression
Role: Principal Investigator
The major goal of this project is to identify the role of the EGFR signaling pathway in wound following acute lung injury.Publications, Most Recent
Hardie WD, Prows DR, Piljan-Gentle A, Wesselkamper SC, Leikauf GD, Korfhagen TR. Dose-related protection form nickel-induced lung injury in transgenic mice expressing human transforming growth factor-αAm J Respir Cell Mol Biol. 26(4):430-437, 2002.
Leikauf GD, McDowell SA, Wesselkamper SC, Hardie WD, Leikauf JE, Korfhagen TR, Prows DR. Acute lung injury: functional genomics and genetic susceptibility.Chest 121:70S-5S, 2002.
Kohn GL, Walston C, Feldstein J, Warner BW, Succop P, Hardie WD. Persistent Abnormal Lung function after Childhood Empyema.Am J Respir Med 1(6): 441-445, 2002.
Le Cras TD, Hardie WD, Fagan K, Whitsett JA, Korfhagen TR. Disrupted Pulmonary Vascular Development And Pulmonary Hypertension in Transgenic Mice Overexpressing Transforming Growth Factor-α.Am J Physiol Lung Cell Mol Physiol. 285: L1046-54, 2003.
Hardie, WD, Le Cras TD, Jiang K, Tichelaar JW, Azhar M, Korfhagen TR. Conditional Expression of Transforming Growth Factor-α in Adult Mouse Lung Causes Pulmonary Fibrosis.Am J Physiol Lung Cell Mol Physiol. 286: L741-49, 2004.
Le Cras TD, Hardie WD, Deutsch GH, Albertine KH, Ikegami M, Whitsett JA, Korfhagen TR. Transient Induction of TGF-α Disrupts Lung Morphogenesis Causing Pulmonary Disease in Adulthood.Am J Physiol Lung Cell Mol Physiol. 287: L718-29, 2004.
Leikauf GD, Hardie WD, Wesselkamper SC, Bachurski CJ, Medvedovic M, Sartor MA, Tomlinson CR, McDowell SA, Henning LM, Case LM, Tichelaar JW, Prows DR, Korfhagen TR. Resolving Gene-Environment Interactions in Complex Traits: Acute Lung Injury.Am J Respir Cell Mol Biol. 31: S23-34, 2004.
Ikegami M, Le Cras TD, Hardie WD, Stahlman M, Whitsett JA, Korfhagen TR. Transforming Growth Factor Perturbs Surfactant Homeostasis In Vivo. In Press Am J Physiol Lung Cell Mol Physiol.
Special Interests
Pulmonary fibrosis, pneumonia, and empyema
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
