Xiaonan Han, PhD
Title
Instructor of Pediatrics
Email
xiaonan.han@cchmc.org
Phone
513-636-7592
Fax
513-636-5581
Credentials
PhD: Department of Pathology, Chinese Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC), Beijing, China, 2000.
Post-doctoral: Department of Anesthesiology / Critical Care Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, 2003.
Awards and Honors
Research Recognition Award, American Physiology Society IBD Conference, Snowmass, CO, 2004.
Career Development Award, Crohn's & Colitis. Foundation of America (CCFA); New York, NY, 2005.
FOCIS travel award (recognizing outstanding research in patient-based immunology), Federation of Clinical Immunology Societies (FOCIS) Annual Meeting, Boston, MA, 2005.
AGA travel award, American Gastroenterology Association (AGA), Los Angeles, CA, 2006.
CCFA Young Investigator Award in IBD, Digestive Disease Week (DDW), Los Angeles, CA, 2006.
Research Grants and Contracts
Characterization of STAT5b as a novel therapeutic target in Crohn's disease, Career development award from CCFA, 1/1/06-12/31/08, Principal Investigator
Publications, Most Recent
Han, X.; Benight, N.; Osuntokun, B.; Loesch, K.; Frank, S.; Denson, L.: Tumor necrosis factor {alpha} blockade induces an anti-inflammatory growth hormone signallng pathway in experimental colitis.Gut, 2006; Epub.
Han, X.; Sosnowska, D.; Bonkowski, E.; Denson, L.A.: Growth hormone inhibits STAT3 activation and reduces disease activity in murine colitis.Gastroenterology, 2005; 129(1):185-203.
DiFedele, L.; He, J.; Bonkowski, E.; Han, X.; Denson, L.A.: Tumor necrosis factor ÿ blockade restores growth hormone signaling in murine colitis.Gastroenterology, 2005; 128(5):1278-91.
Han, X.; Fink, M.P.; Uchiyama, T.; Delude, R.L.: Increased iNOS activity is essential for the development of pulmonary epithelial tight junction dysfunction in endotoxemic mice.Am J Physiol Lung Cell Mol Physiol, 2004; 286(2):L259-67.
Han, X.; Fink, M.P.; Uchiyama, T.; Yang, R.; Delude, R.L.: Increased iNOS activity is essential for the development of hepatic epithelial tight junction dysfunction in endotoxemic mice.Am J Physiol Gastrointest Liver Physiol, 2004; 286(1):G126-36.
Han, X.; Fink, M.P.; Uchiyama, T.; Delude, R.L.: NAD Ameliorates Inflammation-induced Epithelial Barrier Dysfunction in Cultured Enterocytes and Mouse Ileal Mucosa.The Journal of Pharmacology and Experimental Therapeutics, 2003; 307(2):443-9.
Professional Organization Memberships
American Gastroenterology Association (AGA)
American Society of Cell Biology (ASCB)
American Physiological Society (APS)
Special Interests
- Signal Transducer and Activator of Transcription (STAT) in Inflammatory Bowel Disease(IBD)
- Gut barrier dysfunction in IBD
- Drug development in the therapy of IBD
Presentations, Most Recent
Han, X.; Bonkowski, E.; Denson, L.A.: Growth hormone inhibits STAT3 activation and reduces disease activity in murine colitis. Immunological and Pathophysiological Mechanisms in Inflammatory Bowel Disease, Oral presentation and APS Research Recognition Award; September 8-11, 2004; Snowmass, CO.
Han, X.; Denson, L.A.: TNFÿ neutralization restores colon growth hormone signaling in experimental colitis. Digestive Disease Week, oral presentation in distinguished abstract plenary session; 2005; Chicago, IL.
Han, X.; Denson, L.A.: Growth hormone administration modulates STAT5 and NFB activation and reduces crypt epithelial cell apoptosis in experimental colitis. Digestive Disease Week, poster of distinction; 2005; Chicago, IL.
Han, X.; Denson, L.A.: Immunomodulatory effects of growth hormone in Crohn's disease and experimental colitis. Federation Of Clinical Immunology Society (FOCIS), travel award; 2005; Boston, MA.
Han, X.; Osuntokun, B.; Denson, L.A.: STAT5b promotes mucosal tolerance in Crohn's disease and murine colitis. Digestive Disease Week; 2006; Los Angeles, CA.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
