Andreas W. Loepke, MD, PhD
Title
Staff Anesthesiologist
Appointment
Assistant Professor of Clinical Anesthesia and Pediatrics
Email
andreas.loepke@cchmc.org
Phone
513-636-4408
Fax
513-636-7337
Bio
Andreas W. Loepke, MD, PhD, is a clinician-scientist whose areas of expertise include the detection and prevention of neonatal brain injury related to congenital heart disease as well as the effects of anesthetics on the developing brain.
Dr. Loepke has been practicing pediatric cardiac anesthesiology since 2000, first at the Children's Hospital of Philadelphia, and since 2003 at Cincinnati Children's Hospital Medical Center.
He directs a research laboratory in the Institute of Pediatric Anesthesia at the Cincinnati Children's Research Foundation and has been presenting the results of his research at major national and international research meetings.
Dr. Loepke is a Diplomate of the American Board of Anesthesiology and a member of several prominent national and international medical and research societies.
Credentials
MD: University of Dusseldorf, Germany, 1993.
PhD: University of Dusseldorf, Germany, 1995.
Residency: Anesthesiology, Thomas Jefferson Medical College, Philadelphia, PA, 2000.
Fellowship: Pediatric Anesthesia and Pediatric Cardiac Anesthesia, Children's Hospital of Philadelphia, Philadelphia, PA, 2000.
Certification: American Board of Anesthesiology, 2000.
Awards and Honors
Best Anstracts of the Meeting - Second Place, International Anesthesia Research Society 80th Clinical and Scientific Congress, 2006, San Francisco, CA.
Best Pediatric Anesthesia Abstract of the Midwestern Anesthesia Research Conference, 2006, Chicago, IL, awarded to mentee George Istaphanous, MD.
Young Investigator Award - First Place, 2002, Society for Pediatric Anesthesia.
Research
The incidence of congenital heart disease requiring intervention in infancy has been estimated to be 3.5 per 1000 live births. Despite the recent technical advances in the perioperative management of children with congenital cardiac lesions undergoing surgical repair, postoperative results are still suffering from an up to 25% incidence of neurological sequaelae. Alterations of consciousness, seizures, pyramidal and extrapyramidal disorders, as well as a delay in motor and neurologic development are among the problems seen.
In our animal laboratory we use a neonatal piglet model to study the effects of cardiopulmonary bypass and hypoxia/ischemia on the newborn brain. To study the neurologic injury sustained during cardiopulmonary bypass, several contemporary techniques like low-flow cardiopulmonary bypass and deep hypothermic circulatory arrest are utilized.
We strive to characterize the effects of hypothermia and cardiopulmonary bypass as well as hypoxia/ischemia on brain perfusion, oxygenation, and metabolism, as well as analyze different techniques and pharmacologic agents in the prevention of brain damage. To achieve this goal, we employ neurobehavioral, neuropathological as well as biochemical analyses. Our ultimate goal is to improve the life of children at risk for brain damage caused by asphyxia or heart disease.
Research Grants and Contracts
The Neuroprotective Effect of Desflurane in Neonatal Piglets Undergoing Hypothermic Cardiopulmonary Bypass, 2000-2003, Principle Investigator.
The Pharmacodynamics of Desflurane in Neonates Having Surgery for Congenital Heart Malformations, 2001-2003, Co-investigator.
Publications, Most Recent
Loepke, A.W.; McCann, J.C.; Kurth, C.D.; McAuliffe, J.J.: Physiologic Effects of Isoflurane Anesthesia in Neonatal Mice.Anesthesia & Analgesia, 2006; 102:75-80.
Loepke, A.W.; Golden, J.A.; McCann, J.C.; Kurth, C.D.: Injury pattern of the neonatal brain after low-flow cardiopulmonary bypass in a piglet model.Anesthesia and Analgesia, 2005; 101:340-8.
Soriano, S.G.; Loepke, A.W.: Let's Not Throw the Baby Out With the Bath Water - Potential Neurotoxicity of Anesthetic Drugs in Infants and Children.Journal of Neurosurgical Anesthesiology, 2005; 17:207-9.
Loepke, A.W.; Spaeth, J.P.: Glucose And Heart Surgery: Neonates Are Not Just Small Adults.Anesthesiology, 2004; 100:1339-41.
Galinkin, J.L.; Kurth, C.D.; Shi, H.; Priestley, M.A.; Loepke, A.W.; Adamson, P.C.: The Plasma Pharmacokinetics and Cerebral Spinal Fluid Penetration of Intravenous Topiramate in Newborn Pigs.Biopharmaceutics and Drug Disposition, 2004; 25:265-71.
Ditsworth, D.; Priestley, M.A.; Loepke, A.W.; Ramamoorthy, C.; McCann, J.C.; Staple, L.; Kurth, C.D.: Apoptotic Neuronal Death Following Deep Hypothermic Circulatory Arrest in Piglets.Anesthesiology, 2003; 98:1119-27.
Professional Organization Memberships
American Society of Anesthesiologists
American Academy of Pediatrics
Society for Pediatric Anesthesia
International Anesthesia Research Society
Society of Neurosurgical Anesthesia and Critical Care
International Society for Cerebral Blood Flow and Metabolism
Teaching
All CCHMC Anesthesia faculty do anesthesia clinical teaching on an ongoing basis. The faculty are assigned daily in the operating room with a wide variety of anesthesia rotators.
Special Interests
- Neonatal anesthesia
- Neonatal cardiac anesthesia
- Neonatal brain injury related to congenital heart disease
- Effects of anesthetics on the developing brain
Presentations, Most Recent
Anesthesia and the Developing Brain – Protective or Toxic? Grand Rounds Presentation, Department of Pediatrics, Cincinnati Children's Hospital Medical Center; July 2006; Cincinnati, OH.
Does Neonatal Anesthesia Damage the Developing Brain? Grand Rounds Presentation, Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia; June 2006; Philadelphia, PA.
General Anesthesia: Hypnosis, Analgesia, Immobility and Neuroprotection. Invited Lecturer, Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia; May 2006; Philadelphia, PA.
Neurocognitive Function is not Impaired in Adult Mice Exposed to Neonatal Anesthesia. Poster Discussion and Oral Presentation for Best Abstract of the Meeting at the IARS 80th Clinical and Scientific Congress; March 2006; San Francisco, CA.
Toxicity of Inhaled Anesthetics in the Neonatal Brain? Invited Lecturer, 24th Annual Symposium: Clinical Update in Anesthesiology; January 2006; St. Thomas, USVI.
Physiologic Effects of Isoflurane In Neonatal Mice. Poster discussion, American Society of Anesthesiologists Annual Meeting; November 2005; Atlanta, GA.
Inhalational Anesthetics and the Developing Brain: Neurotoxic or Neuroprotective? Invited Lecturer, Grand Rounds Presentation, Department of Anesthesia, University of Cincinnati; May 2005; Cincinnati, OH.
Innovations in Anesthesia and Analgesia. Invited Lecturer, American Association of Laboratory Animal Science District 5 Annual Meeting; May 2005; Mason, OH.
Inhaled Anesthetics and the Neonatal Brain. Department of Anesthesia, Cincinnati Children's Hospital Medical Center; Cincinnati, OH.
Orotracheal Intubation and Controlled Ventilation Allow the Investigation of Volatile Anesthetics During Hypoxia-ischemia in Neonatal Mice. Poster discussion, 79th Clinical and Scientific Congress of the International Anesthesia Research Society; March 2005; Honolulu, HI.
Physiology of Inhalational Anesthesia In Newborn Mice. Poster discussion, Society for Pediatric Anesthesia Winter Meeting; February 2005; Miami Beach, FL.
Inhalational Anesthesia Does not Cause Widespread Neuronal Cell Death in Neonatal Pigs, Rabbits or Mice. Poster discussion, Society for Pediatric Anesthesia Winter Meeting; February 2005; Miami Beach, FL.
Neuroprotection During Pediatric Open-Heart Surgery. Invited Lecturer, 23rd Annual Symposium: Clinical Update in Anesthesiology; January 2005; San Juan, PR.
Neuroprotection During Pediatric Open-Heart Surgery. Research Conference, Department of Anesthesia, Cincinnati Children's Hospital Medical Center; December 2004; Cincinnati, OH.
General Anesthesia Does not Cause Widespread Neuronal Cell Death in the Neonatal Brain – A Study in Three Mammalian Species. American Society of Anesthesiologists Meeting; November 2004; Las Vegas, NV.
Neurotoxicity – Does General Anesthesia Damage The Neonatal Brain? Lecture, Department of Anesthesiology, Cincinnati Children's Hospital Medical Center; Cincinnati, OH.
Brain Injury Pattern and Influencing Factors During Neonatal Hypothermic Low-flow Cardiopulmonary Bypass. Poster discussion, Society of Cardiovascular Anesthesiologists Meeting; April 2004; Honolulu, HI.
Functional and Histologic Damage of the Neonatal Brain Following Low-flow Cardiopulmonary Bypass. Poster discussion, 78th Clinical and Scientific Congress of the International Anesthesia Research Society; March 2004; Tampa, FL.
General Anesthesia Does not Damage the Neonatal Pig Brain. Poster discussion, Society for Pediatric Anesthesia Winter Meeting; March 2004; Phoenix, AZ.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
