Xinhua Lin, PhD
Title
Associate Professor
Appointment
Associate Professor of Pediatrics
Email
xinhua.lin@cchmc.org
Phone
513-636-2144
Fax
513-636-4317
Bio
Xinhua Lin, PhD, completed his doctoral work at the Washington University with Thomas. F. Deuel, where he studied the transcriptional regulation of Platelet-derived growth factor A-chain gene. He then went to the Dr. Norbert Perrimon lab at Harvard Medical School, where he initiated his work on the role of heparan sulfate proteoglycan in cell-cell signaling in Drosophila.
Dr. Lin has identified and characterized two mutations, sugarless and sulfateless, which occur in the genes that encode essential enzymes for the biosynthesis of heparin/heparin sulfate glycosaminoglycan (HSPG). Analyses of these mutants led to the demonstration that HSPGs play critical roles in the signaling activities of several growth factors including Wg, Hh and FGF. Dr. Lin futher demonstrated that glypican members of HSPG play key roles in Wg signaling and the formation of Wg morphogen gradient. He became an assistant professor in April, 2000, at the Children's Hospital Medical Center of Cincinnati. His lab is interested in elucidating the molecular mechanims of cell-cell signaling, focusing on the role of HSPG in signaling and the morphogen gradient formation of the Wg and Hh proteins.
Credentials
PhD: Molecular Genetics, Washington University, St. Louis, MO, 1995.
MS: Cell Biology, Shanghai Institute of Cell Biology, Academia Sinica, P.R. Chiina, 1987.
BS: Biology, Hangchou University, Hangchou, P.R. China, 1984.
Fellowship: Postdoctoral Research Fellow, Howard Hughes Medical Institute/Harvard Medical School, Cambridge, MA, 1995-2000.
Awards and Honors
- Basil O'Connor Scholar Award, March of Dimes, 2002 - 2004
- Breast Cancer Postdoctoral Fellowship Award from U.S. Army, 1997 - 2000
- Young Scientist Award, XVth international Symposium on Glycoconjugates, Japan, 1999
- Wang Kuan-cheng Fellowship Award, Chinese Academy of Sciences, 1999
- Excellent Researcher Award by Shanghai Institute of Cell Biology, 1988
Publications, Most Recent
Lin, X. (2004) Functions of Heparan Sulfate Proteoglycans in cell signaling during development. Development 131, 6009-21.
Belenkaya, T., Han, C. Yan, D., Opoka, R.J., Lin, X., Khodoun, M., Liu, H., and Lin, X. (2004) Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis and is controlled by glypican members of heparan sulfate proteoglycans. Cell, 108(6): 837-47.
Han, C., Belenkaya, T., Khodoun, M., Tauchi, M., Lin, X., and Lin, X. (2004) Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development 131, 1563-75.
Han, C., Belenkaya, T., Wang, B., and Lin, X. (2004) Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin independent process.Development 131, 601-11. This article was highlighted in a commentary by the editor AmandaTromans in Nature Reviews Molecular Cell Biology 5, 256 (2004).
Lin, X. and Perrimon, N. (2003) Developmental Roles of Heparan Sulfate Proteoglycans in Drosophila. Glycoconjugate 19, 363-368.
Belenkaya, T., Han, C., Standley, H., Lin, H., Houston, D., Heasman, J., Lin, X. (2002) Pygopus encodes a nuclear protein essential for Wingless/Wnt signaling. Development 129, 4089-4101.
Li, X., Lin, X. and Guan, MX (2002) Isolation of human homolog of yeast MTo1, which is implicated in mitochondrial tRNA modification and protein synthesis. J. Biol. Chem. 277(30):27256-64.
Liu, C., Li, Y., Semenov, M., Han,C., Baeg, G-H., Tan, Y., Zhang, Z., Lin,X., and He, Xi. (2002). Control of catenin phosphorylation-degradation by a dual-kinase mechanism. Cell, 108(6): 837-47.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
