Francesco T. Mangano, DO, FACOS
Title
Pediatric Neurosurgeon
Director, Pediatric Epilepsy Surgery Program
Appointment
Assistant Professor of Neurosurgery
Email
francesco.mangano@cchmc.org
Phone
513-636-4726
Fax
513-636-2808
Credentials
Doctor of Osteopathic Medicine: Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, PA.
Neurological Surgery Resident: NYCOM-Long Island, Jewish Medical Center / North Shore University Health System, New Hyde Park, NY.
Fellowship, Pediatric Neurosurgery: Washington University School of Medicine-St. Louis Children's Hospital, St. Louis, MO.
Awards and Honors
- Fellow of American College of Osteopathic Surgeons (FACOS) designation, 2009.
- Research project mentor for Dr Ellen Air MD PhD: Awarded Hydrocephalus Association Annual Award, 2009.
- Consumer’s Research Council of America. “America’s Top Physicians” selectio, 2008.
- Consumer’s Research Council of America. “America’s Top Physicians” selection, 2007.
- Scientific paper competition. ACOS Robert C. Erwin Literary Award. Presented at the Annual Clinical Assembly of Osteopathic Specialists, Orlando, FL, October 2005.
- American College of Osteopathic Surgeons / Neurological Surgery Section Annual Resident Paper Competition, 2004.
- American College of Osteopathic Surgeons Resident Achievement Award. Presented at the Annual Clinical Assembly of Osteopathic Specialists, Chicago IL, September 25, 2003.
- New York College of Osteopathic Medicine Educational Consortium (NYCOMEC) Second Annual Resident Research Poster Competition. New York College of Osteopathic Medicine of New York Institute of Technology, Westbury, NY, 2003.
- The Annual Clinical Assembly of Osteopathic Specialists, Poster Presentation Awards - Honorable Mention, Boston, MA, 2000.
- Clinical Assembly of Osteopathic Specialists, Poster Presentation Award, Boston, MA, 2000.
- PCOM Alumni International Traveling Fellowship. Neurosurgical Preceptorship at the National Institute of Neurology, Milan, Italy, 1997.
Research Grants and Contracts
Quantifying white matter degeneration using diffusion tensor imaging (DTI) in pediatric hydrocephalus. Co-principal investigator. Trustee Grant, Cincinnati Children Hospital Medical Center, Sept 2007-Sept 2009.#SPR103674.
Mangano FT. Longitudinal DTI study in children treated for congenital hydrocephalus. Co-Principal Investigator. National Institutes of Health, 2009-2013. #R01-01 NS066932.
Publications, Most Recent
EL Air, W Yuan, SK Holland, BV Jones, KS Bierbrauer, M Altaye,, and FT Mangano. Longitudinal Comparison of Pre- and Post-operative DTI Parameters in Young Children with Hydrocephalus. Journal of Neurosurgery Pediatrics, 2010 (in print).
AA Kadar, MJ Hearst, MH Collins, Mangano FT, and Samy RN. Ewings Sarcoma of the petrous temporal bone: case report and review of the literature. Skull Base, 2010 (In print).
R Desai, CB Stevenson, AH Crawford, AA Durrani, and FT Mangano. C-1 Lateral Mass Screw Fixation in Children with Atlantoaxial Instability: Case Series and Technical Report. Journal of Spinal Disorders and Techniques, 2010 (In print).
Xiang J, Wang Y, Chen Y, Liu Y, Kotecha R, Huo X, Rose DF, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Jones B, Degrauw T. Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals. J Neurosurg Pediatr, Jan Vol# 5, No. 1, pp. 113-122, 2010.
Yuan W, Mangano, FT, Air EL, Holland SK, Jones BV, Altaye A, Bierbrauer K. Anisotropic Diffusion Properties in Infants with Hydrocephalus a DTI Study. Am J Neuroradiol, Aug 6, 2009.
Xiang J, Liu Y, Wang Y, Kirtman EG, Kotecha R, Chen Y, Huo X, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Leach J, Jones BV, Rose D, De Graw T. Frequency and Spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. Epileptic Disord,Vol#11, No. 2, pp. 1-13, 2009.
Leach JL, Mangano FT, Crone K, Lee K, Gelfand M, Maugans T, Rose D. Operative Integration of Multimodality Neuroimaging for Pediatric Neurosurgery :Practical Applications. Pediatr Radiol, 39 (Suppl 2), pp. S311-312, 2009.
Air E, Ghomri YM, Tyagi R, Grande AW, Crone K, and Mangano FT. Management of Vagal Nerve Stimulator Infections. Do they need to be removed? Journal of Neurosurgery, Pediatrics, Jan Vol# 3, No. 1, pp. 73-78, 2009.
Neely J, Leach JL,, Tyagi R, Mangano FT. Traumatic aneurysm of the occipital artery secondary to paintball injury. Clinical Neurology and Neurosurgery, Vol#111, pp.105-108, 2009.
Neely J, Leach JL,, Tyagi R, Mangano FT. Traumatic aneurysm of the occipital artery secondary to paintball injury. In print. Clinical Neurology and Neurosurgery, 2008.
Yuan W, Holland S, Jones BV, Crone K, and Mangano FT. Characterization of Abnormal Diffusion Properties of Supratentorial Brain Tumors: A Preliminary DTI Study. Journal of Neurosurgery: Pediatrics, Apr. Vol# 1, No. 4, pp. 263-269, 2008.
Madera M, Crawford A, and Mangano FT. Management of severe cervical kyphosis in a patient with Larsen’s Syndrome: case report and literature review. In print Journal of Neurosurgery: Pediatrics, Apr. Vol# 1, No. 4, pp. 320-324, 2008.
Mangano, F.T.; Smyth, M.D. Frameless, pinless stereotactic neurosurgery in children. J Neurosurg 104 (6 Suppl Pediatrics): 392-395. Letter to the Editor. Journal of Neurosurgery (7 Suppl Pediatrics) 107:81-82, 2007.
Mangano, F.T.; Curt, B.; Mittler, M.A.; Valderama, E.; Schneider, S.J. Astroblastoma: Review of the Literature and Analysis of Treatment Strategies: Case Report. Journal of Neurosurgical Sciences, Vol. 51 N. 01: 21-28, 2007.
Smyth, M.D.; Limbrick, D.D.; Ojemann, J.G.; Zempel, J.; Robinson, S.; O'Brien, D.F.; Saneto, R.P.; Goyal, M.; Appleton, R.E.; Mangano, F.T.; Park, T.S. Outcome following surgery for temporal lobe epilepsy in pre-adolescent children with hippocampal pathology: emphasis on mesial temporal sclerosis. Journal of Neurosurgery (3 Suppl Pediatrics) 106:205-210, 2007.
Presentations, Most Recent
CB Stevenson, JL Leach, JH Seo, KH Lee, KD Holland, AW Byars, MD Smyth, and FT Mangano. Clinical Outcomes and Functional Recovery Following SMA Resection in Pediatric Epilepsy Surgery. Oral Presentation. Annual Meeting, AANS/CNS Section on Pediatric Neurological Surgery. Boston, MA. December 2 - 5, 2009.
M Mason, KE Deren, WH Yuan, FT Mangano, JP McAllisterII. Effects of Experimental Neonatal Hydrocephalus on White Matter Integrity. Annual Meeting, AANS/CNS Section on Pediatric Neurological Surgery. Boston, MA. December 2 - 5, 2009.
DA Hertzler, NN Patel, WH Yuan, JP McAllister II, KE Deren, C Vorhees, M Williams, SK Holland, and FT Mangano. Correlated Diffusion Tensor Imaging and Locomotor Behavior in an Animal Model of Neonatal Obstructive Hydrocephalus. Annual Meeting, AANS/CNS Section on Pediatric Neurological Surgery. Boston, MA. December 2 - 5, 2009.
DA Hertzler, WH Yuan, A Cancelliere, A Rajagopal, BV Jones, and FT Mangano. Diffusion Tensor Imaging Findings in Children with Benign External Hydrocephalus. Oral Presentation. Annual Meeting, AANS/CNS Section on Pediatric Neurological Surgery. Boston, MA. December 2 - 5, 2009.
Joo Hee Seo, K Holland-Bouley, D Rose, L Rozkhov, H Fujiwara, J Leach, M Gelfand, FT Mangano and K Lee. Role of non-invasive functional imaging in the treatment of intractable nonlesional childhood epilepsy. Annual Meeting, American Epilepsy Society. Boston, MA. December 4 - 8, 2009.
Ki Hyeong Lee, FT Mangano, J Seo, J Leach and CB Stevenson. FMri predicts postoperative language deficit following epilepsy surgery involving supplementary motor area. Annual Meeting, American Epilepsy Society. Boston, MA. December 4 - 8, 2009.
Hee Hwang, K Lee, J Seo, D Rose, K Holland-Bouley and FT Mangano. Surgical treatment of epileptic spasms. Annual Meeting, American Epilepsy Society. Boston, MA. December 4 - 8, 2009.
Lu Meng, J Xiang, W Yuan, Y Wang, Y Chen, X Wang, H Fujiwara, N Hemasilpin, K Lee, FT Mangano, J Leach, K Holland-Bouley and D Rose. Abnormalities of diffusion tensor imaging in epileptic areas in childhood epilepsy. Annual Meeting, American Epilepsy Society. Boston, MA. December 4 - 8, 2009.
Hisako Fujiwara, D Rose, N Hemasilpin, K Lee, FT Mangano, J Seo and D Franz. MEG source localization with multpiple algorithm in pediatric epilepsy surgery candidates with Tuberous Sclerosis Complex. Annual Meeting, American Epilepsy Society. Boston, MA. December 4 - 8, 2009.
Jing Xiang, Y Chen, Y Wang, Y Liu, H Fujiwara, N Hemasilpin, K Lee, FT Mangano, J Leach, D Franz, K Holland and D Rose. Noninvasive detection and localization of pathologic high frequency oscillations in Tuberous Sclerosis Complex with wavelet based beamformer. Annual Meeting, American Epilepsy Society. Boston, MA. December 4 - 8, 2009.
Rose D, Fujiwara H., Hemasilpin N, Lee K., Mangano FT, Holland K., Arthur T, Morita D, Seo, J Stannard, K Meg. Source Localization Algorithms for Interictal Discharges: Strengths, Limitations, and Cautions for Interpretation. Annual Meeting, American Epilepsy Society. Boston, MA. December 4 - 8, 2009.
Mangano FT. Update on the Cincinnati Hydrocephalus Project: Progress in clinical and basic science. Invited Lecture. Annual Clinical Assembly of Osteopathic Surgeons. Oct. 31, 2009. Chicago, Illinois.
H Fujiwara, D Rose, N Hemasilpin, K Lee, FT Mangano, JH Seo D Franz. Comparison of MEG and Intracranial EEG Source Localization with Multiple Algorithms in Patients with Tuberous Sclerosis Complex. ISACM (International Society for the Advancement of Clinical Magnetoencephalography). Athens, Greece. Sept 3-5, 2009.
Joo Hee Seo, James L Leach, Francesco T. Mangano, Charles Stevenson, Ki Hyeong Lee. fMRI predicts postoperative language deficit following epilepsy surgery involving supplementary motor area. AOCCN (Asian Oceanian Congress of Child Neurology). Daegu, South Korea. June, 10-13, 2009.
Joo Hee Seo, Katherine Holland-Bouley, Douglas Rose, Leonid Rozkhov, Hisako Fujiwara, James L. Leach, Michael Gelfand, Francesco T. Mangano, Ki Hyeong Lee. Role of non invasive functional imaging in the treatment of intractable nonlesional epilepsy in childhood. AOCCN (Asian Oceanian Congress of Child Neurology). Daegu, South Korea. June 10-13, 2009.
E.L. Air, W. Yuan, S.K. Holland, B.V. Jones, K. Bierbrauer, and F.T. Mangano. A Longitudinal Comparison of Pre- And Post-operative DTI Parameters In Young Hydrocephalic Children. Oral Presentation. Resident invited lecture as winner of Hydrocephalus Association Award. Annual Meeting, AANS. San Diego, CA. May 3-7, 2009.
Leach JL, Mangano FT, Lee K, Gelfand M, Maugans T, Rose D, Crone K. Operative Integration of Multimodality Neuroimaging for Pediatric Neurosurgery:Practical Applications. Poster presentation. Society for Pediatric Radiology. Carlsbad, California. April 22-25, 2009.
Mangano F.T. The natural history of tethered cord syndrome from pediatric to adult. Invited Lecture. 25th Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves. Oral presentation. Phoenix, AZ. March 11-14, 2009.
Mangano FT. Intramedullary Spinal Cord Tumors: A Surgical Perspective. Oral presentation. Neuro-Oncology Conference. Cincinnati Children’s hospital Medical Center. Cincinnatri, Ohio. September 5, 2008.
H.Fujiwara, D.F. Rose, K.H. Lee, F. T. Mangano, N. Hemasilpin, S. E. Robinson. Source Localization Algorithms for Extracranial/Intracranial MEG/EEG Ictal/ Interictal signals: Surface and Depth. 62nd Annual Meeting of the American Epilepsy Society, 2nd Biennial North American Regional Epilepsy Congress, December 5 - 9, 2008.
A.Atiq Durrani MD, Francesco T Mangano DO, Alvin Crawford MD, Rasesh R. Desai MD, Albert Chavanne MD, Lynn Serrano DO. Instrumented screw fixation of C1 and C2. 23rd Annual North American Spine Society Meeting. Toronto, Ontario, Canada. October 14-18, 2008. Accepted for oral presentation.
Hisako Fujiwara, Douglas F. Rose, Nat Hemasilpin, Ki H. Lee, Francesco T. Mangano, Jing Xiang, Stephen E. Robinson. Comparison of Functional Localization with MEG Somatosensory Evoked Field and Intraoperative or Extraoperative Somatosensory evoked Potentials. 16th International Conference on Biomagnetism, Sapporo, Japan, August 25-29, 2008.
A.Atiq Durrani MD, Francesco T Mangano DO, Alvin Crawford MD, Rasesh R. Desai MD, Albert Chavanne, Lynn Serrano DO. Is Instrumented Screw Fixation of C1 and C2 a Safe and Effective Alternative for Pediatric Cervical Spine Instability? 15th International Meeting on Advanced Spine Techniques (IMAST), Hong Kong, July 8-11, 2008.
W Yuan, P McAllister, D Lindquist, SK Holland, CV Vorhees, MT Williams and FT Mangano. Neuroimaging of white matter changes predict cytopathology and post-surgical behavioral outcome in hydrocephalic rat pups. The 52nd Annual Scientific Meeting of the Society for Research into Hydrocephalus and Spina Bifida, Providence, RI, June 11-15, 2008. Accepted for oral presentation.
W. Yuan, E. Air, M. Altaye, S. Holland, B. Jones, K. Bierbrauer, and F.T. Mangano. Abnormal fractional anisotropy in hydrocephalic children: a DTI study The 52nd Annual Scientific Meeting of the Society for Research into Hydrocephalus and Spina Bifida, Providence, RI, June 11-15, 2008. Accepted for oral presentation.
Weihong Yuan PhD, Scott K. Holland PhD, Blaise V. Jones MD, Kerry R. Crone MD, Katherine Szalewski BS, and Francesco T Mangano DO. White Matter Characteristics in Children with Supratentorial Tumors: a DTI Study. The Society for Pediatric Radiology 51st Annual Meeting. May 7-10, 2008. Accepted for oral presentation.
Abruzzo T, Serrano L, Kleindorfer D, Jones B, Mangano FT, Sauerbeck L, Greely A, Zumberge N, Crone K, Broderick J. Neurovascular Phenotypes in Children with Familial Intracranial Arterial Aneurysms. Presented at the 2008 International Stroke Conference Feb 19-22, New Orleans LA. Accepted for oral presentation.
Abruzzo T, Serrano L, Kocaeli H, Jones B, Zumberge N, Mangano FT, and Zuccarello M. Neurovascular phenotypes among children with ruptured idiopathic intracranial arterial aneurysms, and comparison with the adult phenotype. Presented at the 2008 International Stroke Conference Feb 19-22, New Orleans LA. Accepted for oral presentation.
Ki H. Lee, Douglas F. Rose, Hisako Fujiwara, Jing Xiang, Nat Hemasilpin, Leonnid Rozhkov, Michael Gelfand, Kerry Crone, and Francesco T Mangano. Combination of MEG and SISCOM Enhances the Accuracy of Localization in Refractory Partial Epilepsy. American Epilepsy Society. Philadelphia, PA Dec 1-4, 2007.
Hertzler D, Yuan W, Holland SK, Jones BV, Crone KR, and Mangano FT. DTI findings in post-surgical follow-up for pediatric supratentorial tumor patients. Joint meeting of the AANS/CNS Section on Pediatric Neurological Surgery. Miami, FL Nov. 27- Dec 1, 2007.
Serrano L, Crawford A, Durrani A, Crone KR, and Mangano FT. Instrumented Screw Fixation of C1 and C2 in Pediatric Patients: A Retrospective Review of 10 cases. Joint meeting of the AANS/CNS Section on Pediatric Neurological Surgery. Miami, FL Nov. 27- Dec 1, 2007.
W. Yuan, SK Holland, BV Jones, K. Crone, FT Mangano. DTI study of children with supratentorial tumors. ASNR 45th Annual Meeting, Chicago, IL, 2007.
W. Yuan, SK Holland, BV Jones, B. Dardzinski, K. Crone, K. Bierbrauer, FT Mangano. Normative values of DTI parameters in young children. ASNR 45th Annual Meeting, Chicago, IL, 2007.
Mangano FT. Pediatric Chiari I Malformations. Invited guest lecture at 1st Annual Chiari Awareness Event. Cincinnati, OH September 29, 2007.
Mangano, F.T. Abnormal diffusion characteristics in hydrocephalus. Deptartment of Neurological Surgery Grand Rounds. University of Cincinnati College of Medicine. Cincinnati, OH; June 27, 2007.
Mangano, F.T. A Review of the Guidelines for the Acute Management of Severe Traumatic Brain Injury in Pediatrics. Pediatric Surgery Grand Rounds. Cincinnati Children's Hospital Medical Center, February 21, 2007; Cincinnati, OH.
Professional Organization Memberships
Special Interests
Epilepsy Surgery
Complex Spinal Surgery
Spinal Oncology
Craniofacial Surgery
Neuro-Oncology
Neuroendoscopy
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
