Find a Health Care Professional / Researcher

Francis X. McCormack, MD

Title

Professor of Medicine

Credentials

BA: University of California, San Diego, La Jolla, CA

Internship and Residency: Department of Internal Medicine, University of Michigan

Chief Residency: Department of Internal Medicine, University of Michigan

Fellowship: Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center

MD: University of Texas Medical Branch, Galveston, TX

Awards and Honors

Best Doctors in America, 2008

Publications, Most Recent

Wu H, Kuzmenko A, Wan S, Schaffer L, Weiss A, Fisher JH, Kim KS, McCormack FX: Surfactant proteins A and D inhibit the growth of Gram negative bacteria by increasing membrane permeability.J Clin Invest 111:1589-1602, 2003.

Rodriguez-Capote K, McCormack FX, Possmayer F: Pulmonary surfactant protein-A (SP-A) restores the surface properties of surfactant after oxidation by a mechanism that requires the Cys6 interchain disulfide bond and the phospholipid binding domain.J Biol Chem 278:20461-20474, 2003.

Head JF, Mealy TR, McCormack FX, Seaton BA: Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein.A. J Biol Chem. 278:43254-60, 2003.

Chabot S, Salez L, McCormack FX, Touqui L, Chignard M: SP-A inhibits LPS-induced in vivo production of IL-10 by mononuclear phagocytes during lung inflammation.Am J Respir Cell Mol Biol 28:347-53, 2003.

Karbowniczek M, Astrinidis A, Lium JL, McCormack FX, Colby T, Henske EP: Recurrent lymphangiomyomatosis cells after lung transplantation are derived from the patient, and not from the lung transplant donor.Am J Respir Crit Care Med 167:976-82, 2003.

McCormack FX, Gibbons R, Ward S, Kuzmenko A, Wu H, Deepe GS: Macrophage-independent fungicidal action of the pulmonary collectins.J Biol Chem 278:36250-56, 2003.

Sietsema KE, McCormack FX: Lymphangioleiomyomatosis: insights about, and from, a rare disease.Am J Respir Crit Care Med. 168:1405-6, 2003.

Sietsema KE, McCormack FX: Lymphangioleiomyomatosis: insights about, and from, a rare disease.Am J Respir Crit Care Med 168:1405-6, 2003.

Kuzmenko AI, Wu H, Bridges JP, McCormack FX: Surfactant protein oxidation: Surfactant lipid peroxidation damages surfactant protein A (SP-A) and inhibits interactions with phospholipid vesicles.J Lipid Res 45:1061-8, 2004.

Schaeffer LM, McCormack FX, Wu H, Weiss A: Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A.J Immunol 173:1959-65, 2004.

Crowther JE, Kutala VK, Kuppusamy P, Ferguson JS, Beharka AA, Zweier JL, McCormack FX: Schlesinger LS. Pulmonary surfactant protein A inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity.J Immunol. 172:6866-74, 2004.

McCormack FX: Pulmonary Collectins in the Innate Immune Defense of the Lung.Respir Mol Med, (Japan) 8:89-94, 2004.

McCormack FX, Young LR: Advances in Lymphangioleiomyomatosis.Pulmonary and Critical Care Updates 18:9, 2004.

Schaeffer LM, McCormack FX, Wu H, Weiss A: Interactions of pulmonary collectins with Bordetella bronchiseptica and Bordetella pertussis lipopolysaccharide (LPS) elucidates the structural basis of their antimicrobial activities. Infect Immun. 72:7124-30, 2004.

Beharka AA, Crowther JE, McCormack FX, Denning GM, Lees J, Tibesar E, Schlesinger LS: SP-A activates PI3K / Ca2+ signaling in human macrophages. In press.

Pollock-BarZiv S, Cohen MM, Downey G, Johnson S, Sullivan E, McCormack FX: Air travel in women with Lymphangioleiomyomatosis (LAM). In press.

Kuzmenko AI, Wu H, Wan S, McCormack FX: Surfactant Protein A Is a Principal and Oxidation-sensitive Microbial Permeabilizing Factor in the Alveolar Lining Fluid.J Biol Chem. 280:25913-9, 2005.