Find a Health Care Professional / Researcher

Lisa J. Martin, PhD

Appointment

Research Assistant Professor

Email

lisa.martin@cchmc.org

Phone

513-636-1244

Fax

513-636-7509

Credentials

PhD: (with Honors) University of Kansas, Lawrence KS, 1999

Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002

Awards and Honors

Who's Who in Medicine and Healthcare (4th edition, 2002-2003)
IGES James V. Neel Young Investigator Award 2000

Research

The genetics of normal variation, obesity, reproduction, and asthma.

Research Grants and Contracts

PI: Hinton R
Source: NIH
Dates: 07/01/06 – 06/30/11
Title: The genetic and developmental basis of Pediatric Aortic Valve Disease Pathogenesis
Summary: The goal of this project is to identify the underlying etiology of hypo plastic left heart syndrome.
Role: Co-Investigator

PI: Woo J
Source NIH
Dates 07/01/06 – 06/30/08
Title: Adiponectin in Human Milk and Infant Serum in Relation to Early Adiposity
Summary: The goal of this project is to determine the relationship between milk adiponectin and early adiposity.
Role: Co-Investigator

PI: Benson W
Source: NIH
Dates: 06/01/06 – 05/31/08
Title: Genetic mechanisms of cardiac diseases in the young
Summary: The goal of this project is to clarify the genetic architecture of cardiac disease development in the young.
Role: Co-Investigator

PI: Benson W
Source: NIH/NHLBI
Dates: 1/01/04 – 12/31/08
Title: Molecular mechanisms of valve development and disease
Summary: This study is project 1 of a larger SCCOR grant designed to examine valvular heart disease. Project 1's goal is to identify genes responsible for the development of two types of valvular heart disease: bicusipid aortic valve (BAV) and Ebstein anomaly. This study will perform a genome screen on families ascertained for BAV and refine a previously identified linkage for Ebstein anomaly.
Role: Co-investigator Project 1

PI: Nichols W
Source: NIH
Dates: 10/01/03 – 09/30/08
Title: Cloning the familial primary pulmonary hypertension gene
Summary: The goal of this project is to identify genes that contribute to primary pulmonary hypertension (PPH). This study will perform a genome screen of families ascertained for PPH the candidate genes in the linkage region will be tested for association with PPH.
Role: Co-investigator

PI: Broeckel U
Source: NIH
Dates: 07/01/03 – 06/30/08
Title: Genetics of CRP in Families with Myocardial Infarction.
Summary: The goal of this project is to clarify the genetic basis of CRP and its influence on coronary artery disease and myocardial infarction (MI) through linkage and association studies. This study will identify sequence variants in positional candidate genes and evaluate the effects of these variants with respect to MI and CRP in Caucasian and Hispanic populations.
Role: Co-investigator

PI: Olivier M
Source: NIH
Dates: 07/01/03 – 06/30/08
Title: Genetic Dissection of a QTL Affecting the Lipid Profile.
Summary: The goal of this project is to identify the genetic variants responsible for a linkage of serum triglycerides levels with a QTL on chromsome 7q. This study will identify single nucleotide polymorphisms (SNPs) in this region and determine potentially functional variants using Bayesian quantitative trait nucleotide analysis.
Role: Co-investigator

PI: Martin LJ
Source: ADA
Dates: 07/01/03 – 06/30/08
Title: The metabolic syndrome: the role of plasma adiponectin and common genetic polymorphisms in adolescents.
Summary: The goal of this project is to determine how adiponectin, phenotypically (plasma levels) and genetically (polymorphisms in related genes) covaries with measures of metabolic function in adolescents. This study will use cross-sectional and longitudinal data from an ongoing, longitudinal cohort study. The cross-sectional data will permit the determination of the relationship between adiponectin and phenotypes of the metabolic syndrome, while the longitudinal analysis enables us to examine the time orientation of change and thus may provide support for a causal relationship between adiponectin and the metabolic syndrome.
Role: Principle Investigator

Publications, Most Recent

Tabangin ME, Woo JG, Liu C, Nick T, Martin LJ. Comparison of FDR for Genome-wide and Fine Mapping Regions.BMC Genetics (In Press).

Crimmins NA, Dolan LM, Martin LJ, Bean JA, Daniels SR, Lawson ML, Goodman E, Woo JG. Longitudinal Changes in Adolescent BMI During 3 Years of Follow-up.Journal of Pediatrics (In Press).

Crimmins NA, Woo JG, Kausha RD, Deka R, Dolan LM, Martin LJ. Adiponectin Receptor 1 Gene (ADIPOR1) Variation is Associated with Decreased HOMA-IR Conditional on Adiposity in African-Americans.Obesity (In Press).

Crimmins N, Martin LJ. Polymorphisms in Adiponectin Receptor Genes ADIPOR1 and ADIPOR2 and Insulin Resistance.ObesityReviews (In Press).

North KE, Martin LJ. The Importance of Gene-Environment Interaction: Implications for Social Scientists.Sociological Methods & Research (In Press).

Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and 13q for Bicuspid Aortic Valve and Associated Cardiovascular Malformations.Human Genetics, 2007;121(2):275-84.

Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda S, Tremblay J, Holmer S, Erdmann J, Glöckner G, Harrison H, Martin LJ, Williams JT, Schmitz G, Riegger GAJ, Jacob HJ, Hamet P, Schunkert H. A Locus on Chromosome 10 Influences C-Reactive Protein Levels in Two Independent Populations.Human Genetics, 2007;122(1):95-102.

Martin LJ, Woo JG, Geraghty SR, Altaye M, Davidson BS, Banach W, Dolan LM, Ruiz-Palacios GM, Morrow AL. Adiponectin Is Present in Human Milk and Is Associated with Maternal Factors.AJCN, 2006;83:1106-11.

Woo JG, Dolan LM, Deka R, Kaushal RD, Shen Y, Pal P, Daniels SR, Martin LJ. Interactions between non-contiguous haplotypes in ACDC are associated with plasma adiponectin.Diabetes, 2006;55:523-9.

Mosher MJ, Martin LJ, Cupples LA, Yang Q, Dyer TD, Williams JT, North KE. Genotype-by-sex interaction in the regulation of high-density lipoprotein (HDL): The Framingham Heart Study.Hum Biol, 2005;77:773-93.

Woo JG, Dolan LM, Daniels SR, Goodman E, Martin LJ. Adolescent Sex Differences in Adiponectin are Conditional on Pubertal Development and Adiposity.Obesity Res, 2005;13:2095-101.

Martin LJ, Avery CL, Williams JT, North KE. QTL-Specific Genotype-by-Alcoholism Interaction on Linkage for Evoked EEG Oscillations.BMC Genetics, 2005;S6:123.

Avery C, Martin LJ, Williams JT, North KE. Accuracy of haplotype estimation in a region of low linkage disequilibrium.BMC Genetics, 2005;S6:80.

Molloy CA, Keddache M, Martin LJ. Evidence for linkage on 21q in autism subset with regression.Biol Psych, 2005;10:741-6.

Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan L. The Relationships of Adiponectin with Insulin and Lipids Are Strengthened with Increasing Adiposity.JCEM, 2005;90:4255-9.

North KE, Miller MB, Coon H, Martin LJ, Peacock JM, Arnett DK, Zhang B, Province M, Oberman A, Blangero J, Almasy L, Ellison RC, Heiss G. Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q.Atherosclerosis, 2005;179:119-125.

Sonnenberg GE, Krakower GR, Olivier M, Martin LJ, Comuzzie AG, James RG, Marks JA, Weber JL, Blangero J, Kissebah AH. Genetic determinants of obesity-related lipid traits.J Lipid Res, 2004;45:610-5.

Rogers J, Martin LJ, Comuzzie AG, Mann JJ, Manuck SB, Leland M, Kaplan JR. Genetic analyses of monoamine metabolites in baboons: Overlapping sets of genes influence levels of 5-HIAA, MHPG and HVA.Biological Psychiatry, 2004:55:739-44

Martin LJ, Comuzzie AG, Sonnenberg GE, Myklebust J, James R, Marks J, Blangero J, Kissebah AH. A major quantitative trait locus for resting heart rate maps to a region on chromosome 4.Hypertension, 2004;43:1146-51.

Martin LJ, Cianflone K, Zakarian R, Nagrani G, Almasy L, Rainwater DL, Cole S, Hixson JE, MacCluer JW, Blangero J, Comuzzie AG. Bivariate linkage between acylation-stimulating protein, BMI & HDL on chromosomes 15 & 17.Obesity Research, 2004;12:669-78.

Fairbanks LA, Newman TK, Bailey JN, Jorgensen MJ, Breidenthal SE, Ophoff RA, Comuzzie AG, Martin LJ, Rogers J. Genetic contributions to social impulsivity and aggressiveness in vervet monkeys. Biol Psychiatry, 2004;55:642-7.

Presentations, Most Recent

Martin LJ, Woo JG, Keddache M, Dolan L: Novel Mutations in the Adiponectin Gene (ADIPOQ). Presented at the American Diabetes Association 67th Annual Scientific Session; June 22-26, 2007; Chicago, IL.

Tabangin M, Woo JG, Nick T, Martin LJ: Comparison of FDR for Genome-wide and Fine Mapping Regions. Presented at the Genetic Analysis Workshop; 2006; St. Petersberg, FL.

Smith E, Martin L, Kissebah AH, Olivier M: Comprehensive analysis of a QTL on chromosome 7q36 affecting the lipid profile in the human metabolic syndrome reveals a cluster of genes with small individual effect. Presented at North American Society for the Study of Obesity; 2006; Boston, MA.

Crimmins, NA, Dolan LM, Martin LJ, Bean JA, Daniels SR, Lawson ML, Goodman E, and Woo JG: Longitudinal Stability of the Prevalence and Extent of Adolescent Overweight between 2001-2005. (Poster) Presented at the American Diabetes Association 66th Annual Scientific Session; June 9-13, 2006; Washington D.C.

Woo JG, Martin LJ, Dolan LM, Morrow AL: Birth Weight and Breastfeeding Contribute Independently to Adolescent Adiposity and Insulin Resistance. (Poster) Presented at the Pediatric Academic Society Annual Meeting; April 29 – May 2, 2006; San Francisco, CA.

Woo JG, Martin LJ, Geraghty SR, Altaye M, Davidson BS, Banach W, Ruiz-Palacios GM, Morrow AL: Maternal Factors are Associated with Human Milk Adiponectin Concentrations. (Poster) Presented at the Pediatric Academic Society Annual Meeting, April 29 – May 2, 2006; San Francisco, CA.

Martin LJ, Woo JG, Geraghty SR, Davidson BS, Altaye M, Morrow AL: Adiponectin In Human Milk Is Associated With Infant Weight. (Poster) Presented at the Pediatric Academic Society Meetings; April 29 – May 2, 2006; San Francisco, CA.

Woo JG, Dolan LM, Deka R, Goodman E, Daniels SR, Martin LJ: Adiponectin Gene-Adiposity Interactions Affect High-Density Lipoprotein (HDL) Levels. Presented as a poster presentation at the American Diabetes Association 65th Scientific Sessions; June 10-14, 2005; San Diego, CA.

Martin LJ, Woo JG, Deka R, Goodman E, Daniels SR, Dolan LM: The effect of Adiponectin Gene Variants on Insulin Resistance is a Function of Adiposity. Accepted for a poster presentation at the American Diabetes Association 65th Scientific Sessions; June 10-14, 2005; San Diego, CA.

Crimmins N, Woo JG, Kaushal R, Deka R, Goodman E, Daniels SR, Dolan LM, Martin LJ: Adiponectin Receptor 1 Gene (AdipoR1) Variation is Associated with Decreased HOMA-IR Conditional on Adiposity in African-Americans. Accepted for an oral presentation at the American Diabetes Association 65th Scientific Sessions; June 10-14, 2005; San Diego, CA.

Martin LJ, North KE, Avery CL, Williams JT: Suggestive Evidence for QTL specific G x alcoholism interaction in evoked EEG oscillations. Presented at the Genetic Analysis Workshop 14; September 2004; The Netherlands.

Avery CL, Martin LJ, Williams JT, North KE: Instability of Haplotype Estimation. Presented at the Genetic Analysis Workshop 14; September 2004; The Netherlands.

Woo JG, Deka R, Dolan LM, Martin LJ: Adiponectin Variant -11391 Interacts with Adiposity and Race to Influence Adiponectin Levels in Adolescents. Presented at the Annual Society for Epidemiologic Research meeting; June 15-18, 2004; Salt Lake City, UT.

Woo JG, Dolan LM, Goodman E, Daniels SJ, Martin LJ: Lower Plasma Adiponectin Levels: A Cardiovascular Risk Factor Present in African-American Adolescent Boys. Presented at the American Diabetes Association 64th Annual Scientific Session; June 4-8, 2004; Orlando, FL.

Woo JG, Dolan LM, Goodman E, Daniels SJ, Martin LJ: Adiponectin in Boys and Girls Diverges during Puberty. Presented at the American Diabetes Association 64th Annual Scientific Session; June 4-8, 2004; Orlando, FL.

Martin LJ, Banach W, Dolan LM, Davidson BS, Geraghty SR, Morrow AL: Presence of Adiponectin and Leptin in Human Milk. Presented at the Pediatric Academic Society Annual Meeting; May 1-4, 2004; San Franscisco, CA.

Martin LJ: QTL Mapping in Biological Anthropology: Sex hormone variation. Presented at the 73rd Annual Meeting of the American Association of Physical Anthropologists; April 14-17, 2004; Tampa, FL.