Mark M. Mitsnefes, MD
Title
Attending Physician
Appointment
Associate Professor
Email
mark.mitsnefes@cchmc.org
Phone
513-636-4531
Fax
513-636-7407
Credentials
MD: Gorky Medical Institute, Gorky, Russia
Residency: Pediatrics, Miami Children's Hospital, Miami, Florida
Fellowship: Pediatric Nephrology, Children's Hospital Medical Center, Cincinnati
Awards and Honors
Best Doctors in America, 2008
Research
Cardiovascular complications of chronic renal disease, clinical trials in hypertension
Research Grants and Contracts
Previous Research Support
A Multicenter, Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of Valsartan Given as an Oral Suspension in Pediatric and Adolescent Subjects 2 Months to 16 Years of Age with Hypertension
Agency Novartis (VAL489 A2301-PK)
PI Mark M. Mitsnefes, MD (for Cincinnati Children's)
Dates 2002-2004
A Sub-Study of Protocol K726-01-4002 to Assess the Effect of Ramipril on Ambulatory Blood Pressure and Left Ventricular Mass Index in Children and Adolescents with Hypertension
Agency King's Pharmaceutical (K726-01-4002B)
PI Mark M. Mitsnefes, MD (for Cincinnati Children's)
Dates 2002-2005
A Dose Escalation, Randomized Double-Blind Withdrawal study of the Efficacy Dose-Response and Safety of Ramipril for the Treatment of Hypertension in Children and Adolescents.
Agency King's Pharmaceutical (K726-01-4002)
PI Mark M. Mitsnefes, MD (for Cincinnati Children's)
Dates 2002-2005
A double-blind, randomized, multi-center study followed by 12 months open-label treatment to evaluate the dose-response and safety of valsartan in pediatric hypertensive patients 1-5 years of age
Agency Novartis (CVAL489A2307)
PI Mark M. Mitsnefes, MD (for Cincinnati Children's)
Dates 2004- 2006
A Double-Blind, Randomized, Multicenter Study followed by 12 Months Open-label Treatment to Evaluate the Dose-response and Safety of Valsartan in Pediatric Hypertensive Patients 6-16 years of age
Agency Novartis
PI Mark M. Mitsnefes, MD (for Cincinnati Children's)
Dates 2003-2006
Ambulatory blood pressure monitoring and end-organ damage in children and young adults with renal transplantation.
Agency National Kidney Foundation-Clinical Scientist Award
PI Mark M. Mitsnefes, MD
Dates 7/1/03-6/30/06
Active Research Support
Cardiac disease in children with chronic renal failure
Agency National Institutes of Health (IK23 HL69296)
PI Mark M. Mitsnefes, MD
Dates 07/01/02-06/30/07
Prospective study of chronic kidney disease in children
Agency National Institutes of Health (U01 DK-03-012)
PI Warady
Dates 2003-2008
Role Co-investigator, Co-chair Cardiovascular Committee
A randomized, double-blind, placebo-controlled, multicenter, parallel-arm study assessing the efficacy, safety and dose-response of Ramipril for the treatment of hypertension in children and adolescents.
Agency King's Pharmaceutical
PI Mark M. Mitsnefes, MD
Dates 2007-2009
Role PI for CCHMC
Publications, Most Recent
- Mitsnefes MM, Kartal J, Khoury PR, Daniels SR. (2007) Adiponectin in children with chronic kidney disease: role of adiposity and kidney dysfunction. CJASN 2: 46-51.
- Mitsnefes MM, Kathman TS, Mishra J, Kartal J, Khoury PR, Nickolas TL, Barasch J, Devarajan P. (2007) Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease.Pediatr Nephrol 22:101-108.
- Mitsnefes, MM, Kimball TR, Kartal J, Witt SA, Glascock B, Khoury PR, Daniels SR. (2006) Progression of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up study. J. Pediatrics 149(5): 671-675.
- Mitsnefes MM, Barletta GM, Dresner IG, Chand DH, Geary D, Lin JJ, Patel H. (2006) Severe cardiac hypertrophy and long-term dialysis: the Midwest Pediatric Nephrology Consortium study.Pediatr Nephrol 21:1167-70.
- Mitsnefes M, Kimbal T, Kartal J, Kathman T, Mishra J, Devarajan P. (2006) Serum cystatin C and left ventricular diastolic dysfunction in children with chronic kidney disease.Pediatr Nephrol 21:1293-8.
- Bullington N, Kartel J, Khoury P, Mitsnefes M. (2006) Left ventricular hypertrophy in pediatric kidney transplant recipients: long-term follow-up study.Pediatr Transplant 10:811-5.
- Mitsnefes MM, Subat-Dezulovic M, Khoury PR, Goebel J, Strife CF. (2005) Increasing incidence of post-kidney transplant anemia in children.Am J Transplant 5:1713-8.
- Mitsnefes MM, Knilans T, Mays W, Khoury PR, Daniels SR. (2005) Blood pressure and total peripheral resistance in children with chronic kidney disease.Pediatr Nephrol 20:803-6.
- Mitsnefes MM, Kimball TR, Kartal J, Witt SA, Glascock BJ, Khoury PR, Daniels SR. (2005) Cardiac and vascular adaptation in pediatric patients with chronic kidney disease: role of calcium-phosphorus metabolism.J Am Soc Nephrol 16:2796-803.
- Mitsnefes M, Stablein D. (2005) Hypertension in pediatric patients on long-term dialysis: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS).Am J Kidney Dis 45:309-15.
- Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P. (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.Lancet 365:1231-8.
- Hanevold CD, Ho PL, Talley L, Mitsnefes MM. (2005) Obesity and renal transplant outcome: a report of the North American Pediatric Renal Transplant Cooperative Study.Pediatrics 115:352-6.
- Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, Daniels SR. (2004) Abnormal carotid artery structure and function in children and adolescents with successful renal transplantation.Circulation 110:97-101.
- Mitsnefes MM, Kimball TR, Border WL, Witt SA, Glascock BJ, Khoury PR, Daniels SR. (2004) Impaired left ventricular diastolic function in children with chronic renal failure.Kidney Int 65:1461-6.
- Mitsnefes MM, Kimball TR, Border WL, Witt SA, Glascock BJ, Khoury PR, Daniels SR. (2004) Abnormal cardiac function in children after renal transplantation.Am J Kidney Dis 43:721-6.
Review Articles and Editorials
- Mitsnefes, MM, Kartal J, Khoury PR, Daniels SR. (2007) Adiponectin in children with chronic kidney diesease: Role of adiposity and kidney dysfunction. CJASN 2:46-51.
- Mitsnefes, MM, Kimball TR, Kartal J, Witt SA, Glascock B, Khoury PR, Daniels SR. (2006) Progression of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up study.J Pediatrics 149(5): 671-675.
- Mitsnefes MM. (2005) Cardiovascular morbidity and mortality in children with chronic kidney disease in North America: lessons from the USRDS and NAPRTCS databases.Perit Dial Int 25 Suppl 3:S120-2.
- Patel HP, Mitsnefes M. (2005) Advances in the pathogenesis and management of hypertensive crisis.Curr Opin Pediatr 17:210-4.
- Mitsnefes MM. (2005) Cardiovascular disease in children with chronic kidney disease.Adv Chronic Kidney Dis 12:397-405.
- Mitsnefes MM. (2004) Hypertension and end-organ damage in pediatric renal transplantation.Pediatr Transplant 8:394-9.
Professional Organization Memberships
- American Academy of Pediatrics
- American Society of Nephrology
- National Kidney Foundation
- American Society of Pediatric Nephrology
- International Society of Pediatric Nephrology
Special Interests
Chronic renal disease, dialysis, renal transplantation, hypertension
Honors
- 1985: Honors Diploma, Gorky Medical Institute, Gorky, Russia
- 1999: Kidney Foundation of Greater Cincinnati Research Award
- 2000: Proctor Scholar Award, Children's Hospital Research Foundation
- 2001: Pediatrician Scientist Award, Children's Hospital Research Center
- 2003: Clinical Scientist Award, National Kidney Foundation
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
