Find a Health Care Professional / Researcher

Michael V. Miles, PharmD

Title

Director, Neuropharmacology Laboratory

Appointment

Professor of Clinical Pediatrics and Neurology

Email

michael.miles@cchmc.org

Phone

513-636-7871

Fax

513-636-1888

Bio

Dr. Miles has been a member of the Division of Pediatric Neurology for over 5 years. He is an experienced clinician and researcher, who has studied the pharmacokinetics and pharmacodynamics of drugs in pediatric populations for much of his career. He has dedicated his clinical and research efforts to improving the efficacy and safety of drug therapy for infants and children. His research is currently focused on the development of new biomarkers and therapeutic agents for patients with mitochondrial diseases.

Credentials

PharmD: University of Texas at Austin, Austin, Texas, 1979.

Specialty Residency: Pediatric Clinical Pharmacy, University of Texas at Austin, Austin, Texas.

Certification: Pharmacy, 1976.

Awards and Honors

Chairman of the Ohio River Valley Section of the American Association for Clinical Chemistry, 2006.
Distinguished Abstract Award for "Coenzyme Q10 Associations with Metabolic Syndrome" presented by the National Academy of Clinical Biochemistry at the annual meeting of the American Association for Clinical Chemistry, Los Angeles, California, July 2004.
2004 Best Poster Award for "Coenzyme Q10 Associations with Metabolic Syndrome" at the annual meeting of the Ohio River Valley Regional Conference of the AACC, Dayton, Ohio, 2004.

Research Grants and Contracts

Comparison of Coenzyme Q10 Bioavailability in Healthy Adults. 2000 – 2001; principal investigator.

Children's Hospital Medical Center Pediatric Pharmacology Research Unit. National Institute of Child Health and Development, National Institutes of Health; 1999 – 2002; co-investigator.

Carbamazepine Kinetics and Metabolism During Pregnancy. CDC/Maternal-Fetal Medicine Unit Network; 2001 – 2003; co-investigator.

Publications, Most Recent

Miles MV, Patterson BJ, Chalfonte-Evans M, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL. Ubiquinol-10 improves oxidative imbalance in children with trisomy 21.Pediatric Neurology 2007; 37(6):398-403.

Miles MV. The uptake and distribution of coenzyme Q10.Mitochondrion 2007; 7S:S72-S77.

Tang PH, Miles MV, Steele P, Davidson BS, Geraghty S, Morrow A. Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatography.Biomedical Chromatography 2006; 20(12):1336-1343.

Miles MV, Patterson BJ, Schapiro MB, Hickey FJ, Chalfonte-Evans M, Horn PS, Hotze S. Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial.Pediatric Neurology 2006; 35:542-549.

Jones M, Ryan MA, Miles MV, Tang PH, Fakhoury TA, DeGrauw T, Baumann RJ. Stability of salivary concentrations of the newer antiepileptic drugs in the postal system.Therapeutic Drug Monitoring 2005; 27:576-579.

Miles L, Miles MV, Tang PH, Horn PS, Quinlan JG, Wong B, Wenisch A, Bove KE. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress.Clinica Chimica Acta 2005; 360:87-96.

Miles L, Miles MV, Tang PH, Horn PS, Wong B, DeGrauw T, Morehart P, Bove KE. Coenzyme Q: a potential marker for mitochondrial activity and redox status in skeletal muscle.Pediatric Neurology 2005; 32:318-324.

Presentations, Most Recent

Miles L, Tang PH, Bove KE, Wong BL, DeGrauw T, Morehart PJ, Miles MV. Muscle Coenzyme Q10 predicts abnormal mitochondrial respiratory chain enzyme activity in children. Presented at the 96th Annual Meeting of the United States and Canadian Academy of Patholgy, March, 2007, San Diego, CA.

Miles L, Miles MV, Tang PH, Wong BL, DeGrauw TJ, Dinopoulos A, Morehart PJ, Bove KE. Coenzyme Q content and redox status for diagnosis of mitochondrial abnormalities in muscle biopsies. Presented at the 16th International Congress of Neuropathology, September, 2006, San Francisco, CA.

Patterson BJ, Chalfonte-Evans M, Miles MV, et al. Language impairment is associated with decreased plasma coenzyme Q10 levels in children with Down syndrome. Presented at the 9th World Down Syndrome Congress, August, 2006, Vancouver, Canada.

Miles MV, Morrison JA, Horn PS, Ricciardi R, Harrison HH, Tang PH, Pesce AJ. LPL and NQO1 genotypes are associated with decreased coenzyme Q10 redox ratio in adults with metabolic syndrome: an exploratory study. Presented at the Annual Meeting of the American Association for Clinical Chemistry, July, 2005, Chicago, IL.