Satoshi Namekawa, PhD
Title
Assistant Professor
Email
satoshi.namekawa@cchmc.org
Phone
513-803-1377
Fax
513-803-1160
Credentials
PhD: Department of Applied Biological Science, Tokyo University of Science, Japan, 2005
BS: Department of Applied Biological Science, Tokyo University of Science, Japan, 2000
Research Experience
- Postdoctoral Research Fellow, Laboratory of Dr. Jeannie Lee, Massachusetts General Hospital, Harvard Medical School (Apr/2005-Sept/2009)
- Visiting Graduate student, Laboratory of Dr. Jeannie Lee, Massachusetts General Hospital, Harvard Medical School (Apr/2004-Mar/2005)
- Graduate student, Laboratory of Dr. Kengo Sakaguchi, Tokyo University of Science, Japan (Apr/2000-Mar/2005)
Awards and Honors
- Charles A. King Trust Postdoctoral Research Fellowship (2008-2009)
- Research Fellowship of Japan society for the promotion of science (JSPS: Research Abroad) (2006-2008)
- Research Fellowship of Japan society for the promotion of science (JSPS: DC2) (2003-2005)
Research
The epigenetic program of parental germ cells is required for establishing totipotency in the early embryo and ensuring the continuity of mammalian life. Unique and heritable chromatin modifications are acquired during sperm and egg formation. However, how this epigenetic information is established during germ cell development and transmitted to offspring is largely unclear. The long-term goal of my research is to understand the mechanisms and evolution of epigenetic events during mammalian reproduction.
Publications, Most Recent
Zhang, L. F., Ogawa, Y., Ahn, J. Y., Namekawa, S. H., Silva, S. S., and Lee, J. T (2009). Telomeric RNAs mark sex chromosomes in stem cells. Genetics. Jul;182(3):685-98. Epub 2009 Apr 20.
Namekawa, S. H. and Lee, J. T (2009). XY and ZW: is meiotic sex chromosome inactivation the rule in evolution? PLoS Genet. May;5(5):e1000493. Epub 2009 May 22
Sugawara H., Iwabata K., Koshiyama A., Yanai T., Daikuhara Y., Namekawa S. H., Hamada F. N., and Sakaguchi K. (2009). Coprinus cinereus Mer3 is required for synaptonemal complex formation during meiosis. Chromosoma, 118, 127-139. Epub 2008 Oct 8
Ishii, S., Koshiyama, A., Hamada, F. N., Nara, T. Y., Iwabata, K., Sakaguchi, K., and Namekawa, S. H. (2008). Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1 - a molecular link between recombination and chromatin assembly during meiosis.FEBS J, 275, 2032-2041
Namekawa, S. H., VandeBerg, J. L., McCarrey, J. R., and Lee, J. T. (2007). Sex chromosome silencing in the marsupial male germ line. Proc Natl Acad Sci U S A, 104, 9730-9735.
Kim, S., Namekawa, S. H., Niswander, L. M., Ward, J. O., Lee, J. T., Bardwell, V. J., and Zarkower, D. (2007). A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet, 3, e62.
Hamada, F. N., Koshiyama, A., Namekawa, S. H., Ishii, S., Iwabata, K., Nara, T., Yamaguchi, T., Ishizaki, T., Sakaguchi, K., and Sawado, T. (2007). Coprinus Proliferating Cell Nuclear Antigen (PCNA) interacts with Lim15/Dmc1 but does not stimulate its strand transfer activity. Biochem Biophys Res Commun, 352, 836-842
Koshiyama, A, Hamada, F.N., Namekawa, S.H., Iwabata, K., Sugawara, H., Sakamoto, A., Ishizaki, T., and Sakaguchi, K. (2006). Sumoylation of a meiosis-specific RecA homolog, Lim15/Dmc1, via interaction with the small ubiquitin-related modifier (SUMO)-conjugating enzyme Ubc9. FEBS J, 273, 4003-4012.
Namekawa, S. H., Park, P. J., Zhang, L. F., Shima, J. E., McCarrey, J. R., Griswold, M. D., and Lee, J. T. (2006). Postmeiotic sex chromatin in the male germline of mice. Curr Biol, 16, 660-667.
Presentations, Most Recent
2009
Chiba University, Japan
Cornell University, New York
Cincinnati Children’s Hospital Medical Center, Ohio
Eastern Virginia Medical School, Virginia
2008
Cold Spring Harbor Laboratory Meeting: Germ Cells, New York
The 41st Annual Meeting of the Society for the Study of Reproduction, Hawaii
2006
Gordon Research Conference: Mammalian Gametogenesis and Embryogenesis, Connecticut
2005
University of Tokyo, Japan
