Frank R. Sharp, MD
Title
Professor of Pediatric Neurology
Appointment
Professor of Pediatric Neurology
Email
frank.sharp@uc.edu
Phone
513-558-7082
Fax
513-558-7009
Bio
Frank R Sharp MD. Professor of Neurology and Pediatrics, and Neurosciences Program at the University of Cincinnati. We are currently collaborating with several members of the Pediatric Neurology Department examining the genomic responses in blood related to neurological diseases. These projects include epilepsy and anti-epileptic drugs with Dr. Tracy Glauser, Tourette's syndrome with Dr. Donald Gilbert, and migraine with Dr. Andrew Hershey. Planned new projects will include Trisomy 21 with Dr. Mark Shapiro, neuromuscular diseases with Dr. Brenda Wong, and Tuberous Sclerosis with Dr. David Franz. The goal of these studies is to develop blood genomic markers of the disease that could be helpful in the diagnosis and prognosis of each, and possibly in guiding therapy in the future. Current funding includes three NIH funded grants and one American Heart Association grant.
Other research involves studying mechanisms of neuronal injury following ischemic and hemorrhagic stroke and following subarachnoid hemorrhage in experimental animals. We are developing a recombinant Hsp70 heat shock protein for treating brain injury due to stroke, trauma, seizures and hypoglycemia and should also be useful for treating injury in all organs.
Credentials
MD: University of California at San Diego, San Diego, CA, 1972
Residency: University of California at San Francisco, San Francisco, CA, 1979
Certification: Neurology, 1981
Research Grants and Contracts
Principal Investigator, Neurogenesis and Neural Plasticity, NIH, NINDS, June 1999-2002, RO1 NS38743.
Principal Investigator, Role of Hypoxia Inducible Factor in Stroke, American Heart Association Bugher Stroke award, National Chapter, January 2000-December 2003, 00700006N.
Principal Investigator, Brain Genomic Response to Hypoxia, National Institutes of Health, National Institute of Aging, 1R21 AG19561-01, 4/1/2001-3/31/2003.
Principal Investigator, Intracerebral Hemorrhage Injury Mechanisms,1R01 NS42774, 12/1/2001-11/30/2006.
Principal Investigator, Blood Genomics of Stroke, R21, 7/1-2002-6/2004.
Principal Investigator, NMDA Antagonist Neurotoxicity, 6/2002 - 5/2006. 1RO1 MH 63079-01A1
Principal Investigator, Neuronal Injury and Blood Genomics, RO1 NS43252-01, 7/1/2002 - 6/30/2006.
Publications, Most Recent
Liu, J, Lu AG, and Sharp FR (2001) Microglia/macrophages proliferate in striatum and neocortex but not hippocampus following brief global ischemia that produces ischemic tolerance in gerbil brain, Journal of Cerebral Blood Flow and Metabolism, 21 (4): 361-373.
Sharp FR, Tomitaka M, Bernaudin M, Tomitaka S (2001) Psychosis: Pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia? Trends in Neurosciences, June, 24 (6): 330-334.
Tang Y, Lu A, Aronow B, Sharp FR (2001) Blood genomic responses differ following stroke, seizures, hypoglycemia and hypoxia: Blood genomic fingerprints of disease, Annals of Neurology, December, 51: 695-710.
Lu A, Ran R, Reilly MR, Nee A, Clark J, Sharp FR (2002) Estradiol induces heat shock proteins in arteries and potentiates heat shock protein induction in neurons and glia in ischemic brain, Journal of Cerebral Blood Flow and Metabolism, 22: 183-195.
Clark JF, Reilly MR, Sharp FR (2002) Oxidation of bilirubin produces compounds that cause prolonged vasospasm of rat cerebral vessels: Contributor to subarachnoid hemorrhage induced vasospasm, Journal of Cerebral Blood Flow and Metabolism, 22(4):472-478
Lu A, Ran R, Parmentier S, Nee A, Sharp FR (2002) Geldanamycin induces heat shock proteins in brain and protects against focal ischemia, Journal of Neurochemistry, 81: 355-364.
Murphy P, Sharp A, Shin J, Favrilyuk V, Russo CD, Weinberg G, Sharp FR, Lu A, Heneka MR, Feinstein DL (2002) Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis, Journal of Neuroscience Research, 67: 461-470.
Tang Y, Lu A, Aronow B, Wagner KR, Sharp FR (2002) Genomic responses of brain to ischemic stroke, intracerebral hemorrhage, kainate seizures, hypoglycemia and hypoxia, European Journal of Neuroscience 15 (12), 1937-1952.
Kokubo Y, Matson GB, Liu J, Mancuso A, Kayama T, Sharp FR , Weinstein PR (2002) Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats.
Journal of Neurosurgery. 2002 Jun;96(6):1084-93.
Bernaudin M, Tang Y, Reilly MR, Petit E, Sharp FR (2002) Brain genomic response following hypoxia and re-oxygenation in the neonatal rat: Identification of genes that might contribute to hypoxia-induced ischemic tolerance, Journal of Biological Chemistry, July 26, PUB MED.
Cao G, Pei W, Ge H, Liang O, Luo Y, Sharp FR, Lu A, Ran R, Graham SH, Chen J (2002) In vivo delivery of a Bcl-xL fusion protein containing the TAT Protein Transduction Domain protects against ischemic brain injury and neuronal apoptosis. Journal of Neuroscience 22: 5423-5432.
Glass TF, Reeves B, Sharp FR (2002) Modeling both the mechanical and hypoxic features of traumatic brain injury in vitro in rats. Neuroscience Letters 328(2): 133-136.
Special Interests
Frank R. Sharp, MD, has a special interest in genomics of genetic diseases.
