Saulius Sumanas, PhD
Title
Assistant Professor of Pediatrics
Email
saulius.sumanas@cchmc.org
Phone
513-803-0435
Fax
513-636-4317
Credentials
BS: Vilnius University, Biochemistry, Vilnius, Lithuania, 1995
PhD: University of Minnesota, Department of Biochemistry, Minnepolis / St. Paul, MN, 2000
Postdoctoral Fellow: University of California, Los Angeles, 2002-2007
Awards and Honors
- UCLA Scholars in Oncologic Molecular Imaging Training Award, 2006
- Nomination for the Chancellor's Award for Postdoctoral Research, 2006
- Vascular Biology Training Grant, UCLA, 2004
Research
The Sumanas lab utilizes zebrafish as a model to study molecular mechanisms of vasculogenesis and angiogenesis. We are investigating detailed mechanisms of angioblast formation, specification, differentiation and proliferation and identifying new genes participating in these processes. That includes making novel transgenic zebrafish lines, which will allow us to observe and study formation, migration and differentiation of endothelial progenitor cells in live zebrafish embryos. We are also dissecting transcriptional cascade which controls vasculature formation by utilizing microarray analysis combined with overexpression and gene knockdown studies. And finally, we are performing screens for novel potential regulators of vasculature formation followed by their characterization and functional studies.
Presentations
Presentations, Most Recent
Sumanas S, Gomez G, Zhao Y, Lin S. Evolutionary conserved Etsrp/ER71 signaling controls differentiation of angioblasts into endothelial and myeloid cells. 5th European Zebrafish Genetics and Development Meeting. Amsterdam, Netherlands, 07/2007.
Sumanas S, Lin S. Zebrafish Ets1-related protein is required for both vascular endothelial and myeloid cell formation. 7th International Conference on Zebrafish Development & Genetics. Madison, WI, 06/2006. Oral presentation
Sumanas, S., Lin, S. Novel zebrafish ETS domain protein Etsrp is critical for early vasculogenesis.
Developmental Vascular Biology Workshop II. Pacific Grove, CA, 02/2006.
Society for Developmental Biology 64th Annual Meeting. San Francisco, CA, 07/2005.
4th European Zebrafish Genetics and Development Meeting. Dresden, Germany, 07/2005.
Gordon Research Conference on Vascular Biology. Ventura, CA, 02/2005. Oral presentation
Publications, Most Recent
Sumanas S, Gomez G, Zhao Y, Park C, Choi K, Lin S. (2008). Interplay between Etsrp/ER71, scl and alk8 signaling controls endothelial and myeloid cell formation.Blood 111, 4500-4510.
Sumanas S, Lin S. (2006). Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLOS Biol 4, e10.
Kim HJ, Sumanas S, Palencia-Desai S, Dong Y, Chen J-N, Lin S. (2006). Genetic analysis of early endocrine pancreas formation in zebrafish. Mol Endocrinol 20, 194-203.
Sumanas S, Jorniak T, Lin S. (2005). Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood 106, 534-541.
Sumanas S, Zhang B, Dai R, Lin S. (2005). 15-zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation. Dev Biol 283, 85-96.
Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC. (2005). Wnt5 Signaling in Vertebrate Pancreas Development. BMC Biol 3, 23.
Sumanas S, Lin S. (2004). Zebrafish as a model system for drug target screening and validation (Review).Drug Disc Today: Targets 3, 89-96.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
