Find a Health Care Professional / Researcher

Ying Sun, PhD

Appointment

Research Assistant Professor

Email

ying.sun@cchmc.org

Phone

513-636-0344

Fax

513-636-3486

Credentials

PhD: Pharmacology, University of Cincinnati, Cincinnati, OH, 1992

BA: Pharmacy, Beijing Medical University, Beijing, P.R. China, 1982

Research

Molecular biology and patho-physiology of lysosomal storage disease

Publications, Most Recent

Sun, Y and Ball, WJ. Immunodetection and characterization of the β subunit of Na+, K+-ATPase in mammalian liver tissues.The Sodium Pump: Recent Development, Vol II (Ed. J. Kaplan). Rockefeller Univ. Press, New York, pp.275-280, 1991.

Sun, Y and Ball, WJ. Determination of Na+, K+-ATPase α and β isoforms and kinetic properties in mammalian liver.Am. J. Physiol., 262 (Cell Physiol. 31): C1491-C1499, 1992.

Ball, WJ, Abbott, A, Sun, Y and Malik, B. Using monoclonal antibodies to identify and locate functional regions of Na+, K+-ATPase.Annals of The New York Academy of Sciences, V671, pp436-439, 1992.

Sun, Y and Ball, WJ. Identification of antigenic sites on the Na+, K+-ATPase α-subunit: their sequences and the effects of thiol reduction upon their structure.Biochim. Biophys. Acta, V1207, pp236-248, 1994.

Sun, Y, Witte, DP and Grabowski, GA. Developmental and tissue specific expression of prosaposin mRNA in murine tissues.Am. J. Pathology, V145, No. 6, pp1-17, 1994.

Leonova, T, Qi, X, Bencosme, A, Ponce, E, Sun, Y and Grabowski, GA. Proteolytic processing patterns of prosaposin in insect and mammalian cells.J. Biol. Chem., V271, pp17312-17320, 1996.

Qi, X, Qin, W, Sun, Y, Kondoh, K and Grabowski, GA. Functinal organization of SaposinC: Definition of the neurotrophic and acid α-glucosidase activation regions.J. Biol. Chem., V271, pp6874-6880, 1996.

Xu, Y-H, Ponce, E, Sun, Y, Leonova, T, Bove, K, Witte, D and Grabowski, GA. Turnover and distribution of intravenously administered mannose-terminated human acid α-glucosidase in mice and human tissues.Pediatric Research, V39, pp313-322, 1996.

Sun, Y, Jin P and Grabowski, GA. The mouse prosaposin locus: promoter organization.DNA and Cell Biology, V16, pp23-34, 1997.

Jin, P, Sun, Y and Grabowski, GA. Role of Sp proteins and RORα in transcription regulation of murine prosaposin.J. Biol. Chem., V273, pp13208-13216, 1998.

Sun, Y, Jin, P and Grabowski, GA. Isolation and characterization of the human prosaposin promoter.Gene, V218 (1-2): 37-47, 1998.

Sun, Y, Jin, P and Grabowski, GA. Prosaposin: Localization of promoter regions for CNS and visceral expression in transgenic mice.Biochemical J., V352, pp549-556, 2000.

Jin, P, Sun, Y and Grabowski, GA. In vivo roles of RORα and Sp4 in the regulation of murine prosaposin gene.DNA and Cell Biology, V20, 2001.

Qi, X, Sun, Y and Grabowski, GA. Ex vivo evidence for functional segregation of saposin C action on acid β glucosidase. Molecular genetics and Metabolism. V76, pp189-200, 2002.

Sun, Y, Qi, X, Ponce, E, Quinn, B, and Grabowski, GA. Prosaposin: Threshold rescue and analysis of the neuritogenic region in transgenic mice.Molecular genetics and Metabolism. V76, pp271-286, 2002.

Sun, Y, Witte, DP, Jin, P and Grabowski, GA. Analysis of temporal regulatory elements of prosaposin gene in transgenic mice.Biochemical J. V370, pp557-566, 2002.

Sun, Y, Qi, X and Grabowski, GA. Saposin C is required for normal resistance of acid β-glucosidase to proteolytic degradation. J. Biol. Chem., V278, pp31918-31923, 2003.

Chu, Z, Sun, Y, Kuan, CY, Grabowski, GA and Qi, X. Saposin C: Neuronal Effect and CNS Delivery by Liposomes. (2005) Ann N Y Acad Sci. V1053, p237-46.

Sun, Y, Quinn, B, Witte, DP, and Grabowski, GA. Gaucher disease mouse models: Point mutations at the acid β-glucosidase locus combined with low-level prosaposin expression leads to disease variants. (2005) J. Lipid Res. V46 (10), p2102-2113.

Sun, Y, Xu, Y and Grabowski, GA. Gaucher disease animal models in The Gaucher Disease. Futerman , AH, Zimran, A, Eds., CRC Press, Taylor and Francis, Boca Raton, FL. (2006) p141.

Sun, Y, Quinn, B, Xu, Y, Leonova, T, Witte, DP and Grabowski, GA. Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model. (2006) J. Lipid Res. V47(10), p2161-2170.