Find a Health Care Professional / Researcher

Susan Thompson, PhD

Appointment

Research Associate Professor of Pediatrics

Email

susan.thompson@cchmc.org

Phone

513-636-3899

Fax

513-636-3328

Bio

Susan Thompson, PhD, has research interests that span both genetic and functional genomic studies of juvenile rheumatoid arthritis (JRA) to advance the understanding of the causes and mechanisms of disease pathogenesis. A genome-wide screen for JRA susceptibility traits has been completed and defined several regions for linkage mapping and candidate gene analysis. In addition, complementary approaches that measure global gene expression patterns using DNA microarrays are also being used to understand the molecular basis for disease.

Credentials

PhD: University of Tennessee Center for Health Sciences, Memphis, TN, 1988.
Fellowship: Immunology, St. Jude Children's Research Hospital, Memphis, TN, 1988-1991.
Fellowship: Molecular Genetics, University of Cincinnati, Cincinnati, OH, 1991-1994.

Research

Molecular basis of Juvenile Rheumatoid Arthritis; large-scale integrative analysis of gene expression, polymorphism and other genomic data with clinical data

Research Grants and Contracts

R01 (AR50688); "Genomic Landscapes in Large Scale Integrated JRA Studies"; 09/01/03 – 08/31/07; Principal Investigator.

P30 (AR47363) "Pediatric Rheumatic Disease Cores Center"; 03/15/01-02/28/06; Principal Investigator.

P01 (AR048929); "Gene Expression in Pediatric Arthritis" Core A: "Pediatric Rheumatology Tissue Repository" 07/01/03 – 06/30/08; Principal Investigator, Core A; Co-investigator, Project 1.

N01 (AR42218) "Juvenile Rheumatoid Arthritis as a Complex Genetic Trait"; 9/30/04-9/29/09; Co-Investigator

Publications, Most Recent

Thompson, S. D.; Luyrink, L. K.; Graham, T. B.; Tsoras, M.; Ryan, M.; Passo, M. H.Glass, D. N.: Chemokine receptor CCR4 on CD4+ t cells in Juvenile Rheumatoid Arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios.J Immunol 2001; 166:6899-6906.

Prahalad, S.; Shear, E. S.; Thompson, S. D.; Giannini, E. H.Glass, D. N.: Increased prevalence of familial autoimmunity in simplex and multiplex families with Juvenile Rheumatoid Arthritis.Arthritis Rheum 2002; 46:1851-1856.

Scola, M. P.; Thompson, S. D.; Brunner, H. I.; Tsoras, M. K.; Witte, D.; Van Dijk, M. A.; Grom, A. A.; Passo, M. H.; Glass, D. N.: Interferon-gamma:Interleukin 4 ratios and associated type 1 cytokine expression in Juvenile Rheumatoid Arthritis synovial tissue.J Rheumatol 2002; 29:369-378.

Ogilvie, E. M.; Fife, M. S.; Thompson, S. D.; Twine, N.; Tsoras, M.; Moroldo, M.; Fisher, S. A.; Lewis, C. M.; Prieur, A. M.; Glass, D. N.; Woo, P.: The -174G allele of the interleukin-6 gene confers susceptibility to Systemic Arthritis in children: A multicenter study using simplex and multiplex Juvenile Idiopathic Arthritis families.Arthritis Rheum 2003; 48:3202-3206.

Rosen, P.; Thompson, S.D.; Glass, D.N.: Non-HLA gene polymorphisms in Juvenile Rheumatoid Arthritis.Clin Exp Rheumatol 2003; 21:650-656.

Barnes, M. G.; Aronow, B. J.; Luyrink, L. K.; Moroldo, M. B.; Pavlidis, P.; Passo, M. H.; Grom, A. A.; Hirsch, R.; Giannini, E. H.; Colbert, R. A.; Glass, D. N.; Thompson, S. D.: Gene expression in Juvenile Arthritis and Sspondyloarthropathy: Pro-angiogenic ELR+ chemokine genes relate to course of arthritis.Rheumatology (Oxford) 2004; 43:973-979.

Moroldo, M. B.; Chaudhari, M.; Shear, E.; Thompson, S. D.; Glass, D. N.Giannini, E. H.: Juvenile Rheumatoid Arthritis affected sibpairs: Extent of clinical phenotype concordance. Arthritis Rheum 2004; 50:1928-1934.

Thompson, S. D.; Moroldo, M. B.; Guyer, L.; Ryan, M.; Tombragel, E. M.; Shear, E. S.; Prahalad, S.; Sudman, M.; Keddache, M. A.; Brown, W. M.; Giannini, E. H.; Langefeld, C. D.; Rich, S. S.; Nichols, W. C.; Glass, D. N.: A genome-wide scan for Juvenile Rheumatoid Arthritis in affected sibpair families provides evidence of linkage. Arthritis Rheum 2004; 50:2920-2930.

Presentations, Most Recent:

Thompson, S. D.; Aronow B.J.; Moroldo, M. B.; Luyrink, L. K.; Grom, A. A.; Hirsch, R.; Colbert, R. A.; and Glass, D. N.: Peripheral Blood Gene Expression Patterns In Juvenile Rheumatoid Arthritis (JRA) and Juvenile Spondyloarthropathy (JSpA). Presented at the American College of Rheumatology Annual Meeting, October 2002, New Orleans, LA.

Rosen, P.; Moroldo, M. B.; Lovell, D. J.; Thompson, S. D.; Giannini, E. H.; Glass, D. N.: Discordant Phenotypes for Methotrexate Response in Juvenile Rheumatoid Arthritis. Presented at the American College of Rheumatology Annual Meeting, October 2002, New Orleans, LA.

Ogilvie, E. M.; Fife, M. S.; Twine, N.; Thompson, S.D.; M. Tsoras, S. A. Fisher, C. M. Lewis, A.-M. Prieur, D. Glass, and P. Woo.: TDT Association Study Confirms the IL6 -174 SNP confers Susceptiblity to JIA Systemic Arthritis. Presented at the American College of Rheumatology Annual Meeting, October 2002, New Orleans, LA.

Moroldo, M.B., Giannini E.H., Shear E., Thompson,S.D., and Glass, D.N.: NIAMS- Juvenile Rheumatoid Arthritis Affected Sib-Pair Registry- Update. Presented at the American College of Rheumatology Annual Meeting, October 2002, New Orleans, LA.

Thompson S.D.; Barnes, M.G.; Aronow, B. J.; Luyrink, L. L.; Grom, A. A.; Moroldo, M.B.; Gianinni, E. H.; Colbert, R. A.; Glass, D. N.: Use of Microarrays to Categorize Childhood Arthritis. Presented at the Pediatric Rheumatology Meetings, March 2003, Snowmass, CO.

Thompson, S.D. Moroldo, M.B. Guyer, L.; Ryan, M.; E. Tombragel, E. Shear, S. Furlow, M. Keddache, W. Brown, E. Giannini, C. Langefeld, S. Rich, W. Nichols, and D. Glass.: A Genome-wide Screen in Juvenile Rheumatoid Arthritis (JRA) Affected Sib Pair Families. Presented at the American College of Rheumatology Annual Meeting, October 2003, Orlando, FL.

Barnes, M.;Thompson S. D.; Grom, A. A.; Luyrink, L. K.; Moroldo, M. B.; Aronow, B.; Colbert, R.A.; and Glass, D. N.: Angiogenic/angiostatic chemokine gene expression in Jjuvenile Arthritis. Presented at the American College of Rheumatology Annual Meeting, October 2003, Orlando, FL.

Majka, D.S; Parrish, L.A.; Ferucci, E.D.; Moroldo, M.B.; Thompson, S.D.; Deane, K..D.; Seidel, C.; Arend, W.P.; Glass, D.N.; Norris, J.M.; Holers, V.M.: Antibodies Against Cyclic Citrullinated Peptide (CCP) Are Associated with HLA-DR4 in Juvenile Polyarticular Rheumatoid Arthritis. Presented at the American College of Rheumatology Annual Meeting, October 2003, Orlando, FL.

Thompson, S.D.; Sudman, M.; Srivastava, S.; Valis C.; Keddache, M.A,; Moroldo, M.B.; Guyer, L.; Ryan, M.; Brown, W.M.; Nichols, W.C.; Rich, S.S., Glass, D.N.; Multi-locus Analysis in Juvenile Rheumatoid Arthritis (JRA) Affected Sib Pair Families Identifies a Genetic Interaction Between Chromosomes 1 and 6. Presented at the American College of Rheumatology Annual Meeting, October 2004, San Antonio, TX.

Sudman, M.L.; Guyer,L.; Ryan, M.; Keddache, M.A.; Brown, W.M.; Langefeld, C.D.; Rich, S.S.; Valis, C.; Nichols, W.C.; Moroldo, M.B.; Thompson, S.D.; Glass, D.N.; A MHC-chromosome 2 interaction in JRA affected sibpairs. Presented to the American Society for Human Genetics, October 2004, Toronto, Canada.