Find a Health Care Professional / Researcher

Michael T. Williams, PhD

Appointment

Associate Professor

Email

michael.williams@cchmc.org

Phone

513-636-8624

Fax

513-636-3912

Credentials

Post-Doctoral Fellow in Teratology (October 1997- October 2000) on the Training Grant in Teratology (T32 ES07051). Children's Hospital Research Foundation
Mentor - Professor Charles V. Vorhees, Ph.D.
Research: substituted-amphetamines, learning and memory, neuroendocrinology, neurotoxicology.

Post-Doctoral Fellow in Psychoneuroimmunology (July 1997-Sept 1997) on the Training Grant in Psychoneuroimmunology (T32 MH18831). Ohio State University
Mentor –Phillip T. Marucha, D.M.D., Ph.D.
Research: stress, immunity

Ph.D. Biomedical Sciences (June, 1997), Dissertation title: The effects of restraint, bright lights, and heat during gestation on pregnant female rats, their fetuses, and offspring: emphasis on the hypothalamic-pituitary-adrenal axis. Wright State University. Dissertation Advisor – Harry N. Davis, Jr., Ph.D. (Deceased Oct. 1999).

B.S. Psychology (1990), Wright State University

A.A. Psychology (1987), Belleville Area College

Position History

Associate Professor – Neurology, Cincinnati Children's Research Foundation (September 2006-present)
Assistant Professor - Neurology, Cincinnati Children's Research Foundation (September 2003 – August 2006)
Associate Program Director - (November 2004 – present) and Training Faculty (December 2000- present) on the Training Grant in Teratology (T32 ES07051)
Faculty member of the University of Cincinnati graduate program in Molecular Developmental Biology (October 2002-present)
Faculty member of the University of Cincinnati graduate program in Neuroscience (July 2001-present)
Instructor - Pharmacology Research Center, Cincinnati Children's Research Foundation (December 2000 – August 2003)
Adjunct Instructor of Psychology (Sept. 2000 – 2002), Sinclair Community College
Adjunct Assistant Professor of Psychology (Sept. 1997 – June 2000), Wright State University

MIchael Williams CV (PDF)

Awards and Honors

Pediatric Research Loan Repayment Program Recipient July 2006-2007, NIH
Pediatric Research Loan Repayment Program Recipient July 2004-2006, NIH
Pediatric Research Loan Repayment Program Recipient July 2002-2004, NIH
Post-doctoral Travel Fellowship to attend International Behavioral Neuroscience Society meeting, June 1999
Travel award to attend Midwest Teratology Association, May 1996
Omnitech Travel Fellowship to attend Society of Neuroscience, November 1995
Travel Fellowship to attend International Behavioral Neuroscience Society, April 1993
Graduated (B.S.), Magna Cum Laude, Wright State University, December 1990
Outstanding Achievement in Psychology, Belleville Area College, May 1987

Research

Visit the Williams Lab Site.

Research Grants and Contracts

Investigator, Active

Effects of lead, manganese and stress during development (NIH/NIEHS, 1 R01 ES015689-01 $1,250,000 direct costs over 5 years, 40% effort; 9-2006 – 6-30-2011).
An Emotional Behavior Study in Sprague-Dawley CD/IGS Rats Given LY110140 Daily by Gavage from Postnatal Day (PND) 33 to 62. (Project Director. C.V. Vorhees, PI, M.T. Williams, Eli Lilly, 30% effort, 1/1/2007- 12/31/2007, $292,871 direct costs)
Pending:
None

Investigator, Pending

The effects of 5-methoxy-diisopropyltryptamine 'Foxy'. (NIH/NIDA, 1 R21 DA019495-01).

Co-Investigator, Active

Developmental Effects of Methamphetamine-like Stimulants. (PI: C.V. Vorhees, NIH/NIDA, 2 R01 DA06733-10, 10% effort, 4/1/2005-3/31/2010)
Effects of neonatal MDMA on brain and behavior. (PI: C.V. Vorhees, NIH/NIDA, R01 DA021394, 20% effort 4/1/2006-3/31/2011).
Training Grant in Teratology (PI: C.V. Vorhees, NIH/NIEHS, 2 T32 ES07051)
Genetic Susceptibility to PCB-induced Developmental Neurotoxicity. (PI: C.V. Vorhees, Center for Environmental Genetics Pilot Project Grant, $25,000, 5/1/2007-4-30-2008)
Genetic differences in PCB-induced behavior. (PI: D. W. Nebert, NIH/NIEHS, R21 ES015335, 10% effort, $438,193, 12/15/2007 – 11/30/2009).
Pending:
None

Co-Investigator, Inactive

Developmental interactions of methamphetamine and stress. (NIH/NIDA, 1 K01 DA14269-05, $577,690, 2002-2007).
ADHD phenotype network: Animal model to clinical trial. (PI: F. R. Sallee, NIH/NINDS, 1 R21 MH66212-01).
Developmental Effects of Methylenedioxymethamphetamine. (PI: C.V. Vorhees, NIH/NIDA, 2 R01 DA 11902-03, 10% effort)

Publications, Most Recent

Pan, D., Sciascia, A., Vorhees, C. V., Williams, M. T. (2008). Progression of multiple behavioral deficits during development in a murine model of Hurler Syndrome: Age of onset during development.Brain Research, 1188:241-253.

Grace, C. E., Schaefer, T. L., Herring, N.R., Skelton, M. R., McCrea, A. E., Vorhees, C. V., Williams, M. T. (2008). (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats.Synapse, 62(2):110-121.

Lingrel, J. B., Williams, M. T., Vorhees, C. V., Moseley A. E. (2007). Na,K-ATPase and the role of α isoforms.J Bioenergetics and Biomembranes 39(5-6):385-9. (Review)

Vorhees, C. V., Skelton, M. R., Williams, M. T. (2007). Age-dependent effects of neonatal methamphetamine exposure on spatial learning.Behavioural Pharmacology, 18(5-6):549-562.

Skelton, M. R., Williams, M. T., Schaefer, T. L., Vorhees, C. V. (2007). Neonatal methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits.Psychoneuroendocrinology, 32(6): 734-745.

Williams, M. T.*, Herring, N.R.*, Schaefer, T. L., Skelton, M. R., Campbell N. G., Lipton, J. W., McCrea, A. E., Vorhees, C. V. (2007). Alterations in corticosterone and behavior following the administration of 5-methoxy-diisopropyltryptamine ('Foxy') to adult rats: A new drug of abuse. *denotes equal authorship.Neuropsychopharmacology 32: 1404-1420.

Vorhees, C. V., Schaefer, T. L., Williams, M. T. (2007). Developmental exposure to 3,4-methylenedioxymethamphetamine results in differential long-term deficits in spatial vs. path integration learning as a function of dose distribution.Synapse 61(7): 488-499.

Moseley A. E.*, Williams, M. T.*, Schaefer, T. L., Bohanan, C. S., Behbehani, M. M., Vorhees, C. V., Lingrel, J. B. 07). Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity and anxiety in mice. *denotes equal authorship.Journal of Neuroscience 27(3):616-626.

Skelton, M. R., Williams, M. T., Vorhees, C. V. (2006). Treatment with MDMA from P11-20 disrupts spatial learning and path integration learning in adolescent rats but only spatial learning in older rats.Psychopharmacology 189(3):307-318.

Thacker, S. K., Perna, M. K., Ward, J. J., Schaefer, T. L., Williams, M. T., Kostrzewa, R. M., Brown, R. W. (2006). The effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male and female rats neonatally treated with quinpirole.European Journal of Neuroscience. 24:2075-2083.

Williams, M. T., Furay, A. F., Ehrman, L. A., Schaefer, T. L., Vorhees, C. V. (2006). Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: the effect of prior drug exposure.Stress 9(3): 153-163.

Vorhees, C. V., Williams, M. T. (2006). Morris water maze: Procedures for assessing spatial and related forms of learning and memory.Nature Protocols, 1(2): 848-858.

Schaefer, T. L., Ehrman, L. A., Gudelsky, G. A., Vorhees, C. V., Williams, M. T. (2006). A comparison of monoamine and corticosterone levels 24 hours following d-methamphetamine, ±3,4-methylenedioxymethamphetamine, cocaine, d-fenfluramine, or methylphenidate administration in the neonatal rat.Journal of Neurochemistry 98(5): 1369-1378.

Ehrman, L. A., Williams, M. T., Schaefer, T. L., Gudelsky, G. A., Reed, T. M., Fienberg, A. A., Greengard, P., Vorhees, C. V. (2006). Phosphodiesterase 1B modulates the effects of methamphetamine on locomotor activity and spatial learning through a DARPP32-dependent pathway: evidence from PDE1B-DARPP32 double knockout mice.Genes, Brain, and Behavior, 5: 540-551.

Able, J. A., Gudelsky, G. A., Vorhees, C. V., Williams, M. T. (2006). ±3, 4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory.Biological Psychiatry, 59(12): 1219-1226.

Crawford, C. A., Williams, M. T., Kohutek, J. L., Choi, F. A., Yoshida, S. T., McDougall, S. A., Vorhees, C. V. (2006). Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPγS binding in adult rats.Brain Research, 1077: 178-186.

Brown, R. W., Perna, M. K., Schaefer, T. L., Williams, M. T. (2006). The effects of nicotine on D2-mediated behaviors and neurotrophins of rats neonatally treated with quinpirole.Synapse 59(5): 253-259.

Becker, L. A., Kunkel, A. J., Brown, M. R., Ball, E. E., Williams, M. T. (2005). Effects of dietary phytoestrogen exposure during perinatal period.Neurotoxicology and Teratology 27(6):825-834.

Brunskill, E. W., Erhman, L. A., Williams, M. T., Klanke, J., Hammer, D., Schaefer, T. L., Sah, R., Dorn, G. W., Potter, S. S., Vorhees, C. V. (2005). Abnormal neurodevelopmental, behavioral, and neurotransmitter signaling in NPAS-3 deficient mice.European Journal of Neuroscience 22(6): 1265-1276.

Cohen, M. A., Skelton, M. R., Schaefer, T. L., Gudelsky, G. A., Vorhees, C. V., Williams, M. T. (2005). Learning and memory after neonatal exposure to 3,4 methylenedioxymethamphetamine (ecstasy) in rats: Interaction with exposure in adulthood.Synapse 57(3): 148-159.

Williams MT, Schaefer TL, Ehrman LA, Able JA, Gudelsky GA, Sah R., Vorhees CV (2005). 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rat increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity.Brain Research 1039(1/2):95-105.

Vorhees CV, Reed TM, Morford LL, Fukumura M, Wood SL, Brown CA, Skelton MR, McCrea AE, Rock SL, Williams MT (2005). Periadolescent rats (P41-50) exhibit increased susceptibility to d-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60).Neurotoxicology and Teratology 27(1): 117-134.

Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, Sharp FR, Rakic P (2004). Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain.Journal of Neuroscience 24(47):10763-10772.

Skelton MR, Blankemeyer TL, Gudelsky GA, Brown-Strittholt CA, Vorhees CV, Williams MT (2004). Metyrapone attenuates the sequential learning deficits, but not monoamine depletions following d,l-fenfluramine administration to adult rats.Synapse 54(4): 214-222.

Williams MT, Brown CA, Skelton MR, Vinks AA, Vorhees CV (2004). Absorption and clearance of ±3,4-methylenedioxymethamphetamine from the plasma of neonatal rats.Neurotoxicology and Teratology 26(6): 849-856.

Vorhees CV, Reed TM, Skelton MR, and Williams MT (2004). Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning.International Journal of Developmental Neuroscience. 22(5/6): 247-259.

Williams MT, Moran MS, Vorhees CV. (2004). Behavioral and growth effects induced by low dose methamphetamine administration during the neonatal period in rats.International Journal of Developmental Neuroscience. 22(5/6): 273-283.

Brown RW, Flanigan TJ, Thompson KN, Thacker SK, Schaefer TL, Williams MT (2004). Neonatal quinpirole treatment impairs Morris water task performance in early postweanling rats: Relationship to increases in corticosterone and decreases in neurotrophic factorsBiological Psychiatry 56(3):161-168.

Williams MT, Brown RW, Vorhees CV (2004). Neonatal methamphetamine administration induces region-specific long-term neuronal morphological changes in the rat hippocampus, nucleus accumbens, and parietal cortex.European Journal of Neuroscience 19(12): 3165-3170.

Brown RW, Thompson KD, Thompson KN, Ward JJ, Thacker SK, Williams MT, and Kostrzewa RM. (2004). Adulthood nicotine treatment alleviates behavioral impairments in rats neonatally treated with quinpirole: Possible roles of acetylcholine function and neurotrophic factor expression.European Journal of Neuroscience 19(6): 1634-1642.

Williams MT, Blankemeyer TL, Schaefer TL, Brown CA, Gudelsky GA, Vorhees CV (2003). Long-term effects of neonatal methamphetamine exposure in rats on spatial learning in the Barnes maze and on cliff avoidance, corticosterone release, and neurotoxicity in adulthood.Dev Brain Res 147(1-2): 163-175.

Williams MT, Moran MS, Vorhees,CV. (2003) Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze.Psychopharmacology 168, 329-338.

Williams MT, Morford LL, Wood SL, Wallace TL, Fukumura M, Broening HW, Vorhees CV (2003). Developmental d-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory.Synapse 48, 138-148.

Crawford CA, Williams MT, Newman, E. R., McDougall SA, Vorhees CV (2003) Early postnatal methamphetamine exposure causes prolonged changes in dorsal striatal protein kinase A activity, dopamine D2-like binding sites, and dopamine content.Synapse 48, 131-137.

Williams MT, Morford LL, Wood SL, Rock SL, McCrea AE, Fukumura, M., Wallace TL, Broening HW, Moran MS, Vorhees CV (2003). Developmental 3,4-methylenedioxymethamphetamine (MDMA)-induced learning deficits are not related to undernutrition or litter effects: novel use of litter size to control for MDMA-induced growth decrements.Brain Research 968 (1), 89-101.