Find a Health Care Professional / Researcher

Lisa R. Young, MD

Title

Director, Pediatric Rare Lung Diseases Program, Division of Pulmonary Medicine

Appointment

Assistant Professor of Pediatrics and Medicine, Division of Pulmonary Medicine, University of Cincinnati College of Medicine

Email

lisa.young@cchmc.org

Phone

513-636-6771

Fax

513-636-4615

Credentials

BA: University of Virginia, Charlottesville, VA 1993.
MD: Duke Univeristy School of Medicine, Durham, NC 1997.
Residency: Internal Medicine and Pediatrics, Duke University Medical Center, Durham, NC 2001.
Fellowship: Pediatric Pulmonology and Pulmonary and Critical Care Medicine Cincinnati Children's Hospital Medical Center and the University of Cincinnati 2005.
Certifications: Internal Medicine, 2001; Pediatrics, 2001; Pediatric Pulmonology, 2006; Adult Pulmonary Medicine (ABIM), 2006.

Awards and Honors

Best Doctors in America, 2008
Central Society for Clinical Research, Early Career Development Award, 2008
American Thoracic Society Carl Booberg Research Award, 2007
Procter Research Scholar, Cincinnati Children's Hospital Medical Center, 2005-2007
Member, Writing Group, American Thoracic Society Consensus Statement on the Approach to the Young Child with Interstitial Lung Disease, 2005-present

Research Grants and Contracts

Mechanisms of pulmonary inflammation and fibrosis in the Pearl mouse model of Hermansky-Pudlak Syndrome. Principal Investigator. Parker B. Francis Fellowship, Parker B. Francis Foundation: 7/1/07-6/30/10.

A double blind placebo controlled trial of Sirolimus in patients with Lymphangioleiomyomatosis (LAM). Phase III Trial of Sirolimus in Lymphangioleiomyomatosis. Co-investigator. Food and Drug Administration. 8/1/09– 7/30/10. #1 RO1 FD003362.

Utility of VEGF-D as a Biomarker in Lymphangioleiomyomatosis. Principal Investigator. Pilot Project Grant, Lymphangioleiomyomatosis (LAM) Foundation. 1/1/08-7/31/10.

Alveolar Cell Dysfunction and Pulmonary Fibrosis. Principal Investigator. National Institute of Health/National Heart, Lung and Blood Institute. 9/1/07 to 8/31/12. #K08 HL082757-0.

LAMS Clinic Research Network. Co-investigator Department of Defense (DOD). 4/1/10-3/31/13

Publications, Most Recent

GH Deutsch and LR Young. Histologic Resolution of Pulmonary Interstitial Glycogenosis. Pediatr Dev Pathol Mar 2009; 25:1. [Epub ahead of print].

AS Brody, RB Guillerman, TC Hay, RR Deterding, LR Young, GH Deutsch, LL Fan. Neuroendocrine Cell Hyperplasia of Infancy: Appearance on HRCT. American Journal of Roentgenology January 2010; (in press).

AL Snow, RA Marsh, P Roehrs, D Dahr, S Krummey, LR Young, J van Hoff, K Zhang, AH Filipovich, HC Su, J Bleesing, and MJ Leonardo. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. J Clin Invest 2009; 119(10): 2976-89.

LR Young, DN Franz, P Nagarkatte, C Fletcher, KA Wikenheiser-Brokamp, MD Galsky, TC Corbridge, AP Lam, MJ. Gelfand, and FX McCormack. Utility of FDG-PET in Sporadic and Tuberous Sclerosis Associated Lymphangioleiomyomatosis. Chest 2009; 136(3):926-33.

V Schmithorst ,TA Altes, LR Young, FX McCormack, and A Brody. An Automated Algorithm for Quantifying the Extent of Cystic Change On Volumetric Chest CT: Initial Results in Lymphangioleiomyomatosis. AJR Am J Roentgenol 2009; 192(4):1037-44.

Diagnostic Potential of Serum VEGF-D for Lymphangioleiomyomatosis.New England Journal of Medicine 2008;358:199-200.

JJ Bissler, FX McCormack, LR Young, JM Elwing, G Chuck, JM Leonard, VJ Schmithorst, T Laor, AS Brody, JA Bean, S Salisbury, DN Franz. Efficacy and Safety of Sirolimus for Angiomyolipomata in Patients with Tuberous Sclerosis Complex and Lymphangioleiomyomatosis. New England Journal of Medicine 2008;358:140-51.

LR Young, LM Nogee, B Barnett, RJ Panos, TV Colby, GH Deutsch. Usual Interstitial Pneumonia (UIP) in an Adolescent with ABCA3 Mutations. Chest 2008; 134: 192-195.

GH Deutsch, LR Young*, RR Deterding, LL Fan, SD Dell, JA Bean, AS Brody, LM Nogee, BC Trapnell, C Langston and the Pathology Cooperative Group. Cross-sectional Evaluation of Diffuse Lung Disease in Young Children: Application of a Novel Clinical-Pathologic Classification Scheme.AJRCCM, published ahead of print on September 20, 2007 as doi:10.1164/rccm.200703-393OC.

HD Thomas, K Risma, TB Graham, AS Brody, LR Young, PM Joseph. A Kindred of Children with Interstitial Lung Disease.Chest 2007;132:221-30.

LR Young, R Pasula, PM Gulleman, GH Deutsch, FX McCormack. Susceptibility of Hermansky-Pudlak Mice to Bleomycin-Induced Type II Cell Apoptosis and Fibrosis.AJRCMB 2007;37:67-74.

AL Prestridge, JL Wooldridge, GH Deutsch, LR Young, SE Wert, JA Whitsett, L Nogee. Persistent Tachypnea and Hypoxia in a 3-month-old Term Infant (ABCA3).J Pediatr 2006;149:702-6.

K Almoosa, J Mendez, J Huggins, LR Young, M Coutinho, S Byrnes, E Sullivan, J Ryu, SP Bar-Ziv, J Maurer, FX McCormack, S Sahn. Pneumothorax in Lymphangioleiomyomatosis.Chest 2006;129:1274-81.

LR Young, K Almoosa, SP BarZiv, M Coutinho, FX McCormack, and S Sahn. Patient Perspectives on Pneumothorax and Management in Lymphangioleiomyomatosis.Chest 2006;129:1267-73.

LR Young, MT Borchers, R Gibbons, H Allen, FX McCormack. Lung Restricted Macrophage Activation in the Pearl Mouse Model of Hermansky Pudlak Syndrome.J Immunology 2006;176(7):4361-8.

MT Borchers, NL Harris, SC Wesselkamper, S Zhang, Y Chen, LR Young, GW Lau. The NKG2D Activating Receptor Mediates Pulmonary Clearance of Pseudomonas aeruginosa.Infection and Immunity 2006;74(5):2578-86.

F Kong, LR Young, H Ran, M Meyers, Y Chen, P Joseph, DJ Hassett, GW Lau. Pseudomonas Aeruginosa Pyocyanin Inactivates Lung Epithelial V-ATPase Activity, Thereby Inhibiting Expression and Trafficking of the Cystic Fibrosis Transmembrane Regulator.Cell Microbiology 2006;8(7):1121-33.

Book Chapters and Invited Reviews

LR Young and WA Gahl. Hermansky-Pudlak Syndrome. Molecular Basis of Rare Lung Diseases, FX McCormack, BC Trapnell, and RJ Panos (editors). Humana Press (in press).

BC Trapnell and LR. Young Pulmonary Alveolar Proteinosis. Rudolph’s Pediatrics, revised edition (in press).

LR Young. Childhood Interstitial Lung Diseases.Diffuse Lung Disease: A Practical Approach, 2nd ed, Robert P. Baughman and Roland M. du Bois (editors). Springer Scientific (in press).

LR Young, J Hagood. Childhood Interstitial Lung Disease is not the Same as Adult ILD. Invited review, ADVANCE for Respiratory Care, October 2006.