Aaron M. Zorn, PhD
Appointment
Associate Professor, University of Cincinnati College of Medicine
Email
aaron.zorn@chmcc.org
Phone
513-636-3770
Fax
513-636-4317
Credentials
BSc University of Toronto, Canada
PhD University of Texas, Austin, Texas, 1995
Postdoctoral Wellcome Trust Cancer Research Campaing Institute, University of Cambridge, Cambridge, England, 1996-1999
Research Fellow Wellcome Trust Gurdon Institute, Universtiy of Cambridge, Cambridge, England, 1999-2002
Awards and Honors
Wellcome Trust Fellow. 1998-2001
Natural Sciences and Engineering Research Council of Canada, Postdoctoral Fellowship Award. 1995-1997
Research
Visit the Zorn Lab Site.
Research Grants and Contracts
Active:
NIH R01 DK080823 (AM Zorn and JM Wells, P.I.s): Mammalian liver and foregut development. 01/2009-12/2014
NIH R01DK07858 (AM Zorn, P.I.): Molecular basis of liver development. 4/01/2007-03/31/2012
NIH R01GM072915 (JM Wells, P. I., AM Zorn, Co-investigator): Mechanisms of endoderm specification along the A-P axis. 5/1/2006-4/30/2011
Past:
NIH R01HD042572 (AM Zorn, P.I.): Molecular Basis of Endoderm Development. 7/1/2002-6/30/2008
NIH R01 HD45737 (C. Wylie, P.I.; AM Zorn, Co-Investigator): Ectoderm Formation in the Early Xenopus Embryo. 02/14/04-12/31/08
Wellcome Trust, UK, CDF 55703 (AM Zorn, P.I.): Molecular Mechanisms of Endodermal Patterning. 2/1999 – 2/2002
Publications, Most Recent
Aaron Zorn's publications as listed by PubMed.
Xu K, Chong D, Rankin SA, Zorn AM and Cleaver O (2009) Rasip1 is required for endothelial cell migration, angiogenesis and vessel formation. Developmental Biology, in press.
Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA (2009) Sox17 Promotes Cell Cycle Progression and Inhibits TGF-ß/Smad3 Signaling to Initiate Progenitor Cell Behavior in the Respiratory Epithelium. PLoS ONE 4:e5711
Kormish JD, Sinner D and Zorn AM (2009) Interactions between SOX factors and Wnt/?-catenin signaling in development and disease. Dev. Dyn. In press.
Rankin SA, Hasebe T, Zorn AM and Buchholz RD (2009) Improved Cre reporter transgenic Xenopus. Dev. Dyn. In press.
Zorn AM, Liver development (2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.25.1, http://www.stembook.org.
Zorn AM and Wells JW (2009) Endoderm Development and Organ Formation Annual Review of Cell and Developmental Biology. Editor Janet Rossant. In press.
Sartor MA, Zorn AM, Schwanekamp JA, Halbleib D, Karyala S, Howell ML, Dean GE, Medvedovic M, Tomlinson CR. (2006) A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus. Nucleic Acids Res Jan 5;34(1):185-200.
Park KS, Wells JM, Zorn AM, Wert SE, Whitsett JA. (2006) Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol 294:192-202.
Sinner D, Kirilenko P, Rankin S, Wei E, Howard L, Kofron M, Heasman J, Woodland HR, Zorn AM. (2006) Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development 133:19555-1966. *This paper was selected by the "Faculty of 1000"
Mir A, Kofron M, Zorn AM, Bajzer M, Haque M, Heasman J, Wylie CC. (2007) FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula. Development. 134:779-88.
McLin VA, Rankin SA, Zorn AM. (2007) Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 134: 2207-2217.
Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP. (2007) Mutations in cardiac T-box factor TBX20 are associated with diverse cardiac pathologies including defects of septation and valvulogenesis, and cardiomyopathy. Amer Jour Hum Gen 81: 280-291.
Kirilenko P, Weierud FK, Zorn AM, Woodland HR. (2007) Efficiency of primordial Xenopus germ cell migration depends on the germ plasm mRNA encoding the PDZ domain protein Grip2. Differentiation 27:7802-7815.
Sinner D, Kordich JJ, Opoka R Rankin SA, Lin S-J, Jonatan D, Zorn AM*, Wells JM*. (2007) Sox17 and Sox4 differentially regulate beta-catenin/TCF activity and proliferation of carcinoma cells. Mol Cell Biol 27: 7802-7815. *corresponding authors (PMC2169141)
Zorn AM, Wells JM. (2007) Molecular basis of vertebrate endoderm development. International Review of Cytology 259:49-111
Woodland HR, Zorn AM. (2008) The core endodermal gene network of vertebrates: Combining developmental precision with evolutionary flexibility. BioEssays 30:1-9.
Costa RMB, Soto X, Chen Y, Zorn AM, Amaya E. (2008) Spib is required for primitive myeloid development in Xenopus. Blood 12:2287-96.
Li Y, Rankin SA, Sinner D, Kenney, AP, Krieg PA, Zorn AM. (2008) Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and non-canonical Wnt11 signaling. Genes & Development 22:3050-3063.
Presentations, Most Recent
2006 University of Arizona Anatomy Dept. Seminar Series, Tuscon AZ
2006 Cold Spring Harbor, Xenopus Course NY
2006 FASEB Liver meeting Snowmass CO
2006 International Xenopus Meeting, Tokyo, Japan
2006 Chinese Academy of Science, Institute of Zoology, Kunming, China
2006 Johnson & Johnson, Skilman, NJ
2007 Albert Einstein College of Medicine, Liver Center, NY
2007 University of Pennsylvania School of Medicine, Philadelphia, PA
2007 Fox Chase Cancer Center, Philadelphia, PA
2007 Louisville, Birth Defects Center
2008 Keystone Wnt meeting, Keystone CO
2008 International Xenopus meeting, Germany
2008 NIH, MGC symposium, Bethesda, Maryland, USA
2008 AASLD meeting Stem cell workshop San Francisco, CA
2008 University of Illinois-Chicago, Dept. Molecular Genetics, Seminar Series
2008 University of Michigan, Center for Organogensis, Seminar Series
Special Interests
Molecular and cellular mechanisms of embryoinc endoderm development and organ formation.
Other Areas
Member of the strategic committee for the Xenopus tropicalis EST and Genome sequencing project
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
