Aaron M. Zorn, PhD
Appointment
Assistant Professor
Email
aaron.zorn@chmcc.org
Phone
513-636-3770
Fax
513-636-4317
Credentials
BSc University of Toronto, Canada
PhD University of Texas, Austin, Texas, 1995
Postdoctoral Wellcome Trust Cancer Research Campaing Institute, University of Cambridge, Cambridge, England, 1996-1999
Research Fellow Wellcome Trust Gurdon Institute, Universtiy of Cambridge, Cambridge, England, 1999-2002
Awards and Honors
Wellcome Trust Fellow. 1998-2001
Research
Visit the Zorn Lab Site.
Research Grants and Contracts
NIH R01DK07858 (AM Zorn, P.I.): Molecular Basis of Liver Development. 4/01/2007-03/31/2012
NIH R01HD042572 (AM Zorn, P.I.): Molecular Basis of Endoderm Development. 7/1/2002-6/30/2008
NIH R01GM072915 (JM Wells, P. I., AM Zorn, Co-investigator): Mechanisms of Endoderm Specification Along the A-P Axis. 5/1/2006-4/30/2011
NIH R01 HD45737 (C. Wylie, P.I.; AM Zorn, Co-Investigator): Ectoderm Formation in the Early Xenopus Embryo. 2/14/04-12/31/08
Publications, Most Recent
Aaron Zorn's publications as listed by PubMed.
Zorn, AM, Butler, K and Gurdon, JB (1999) Anterior Endomesododerm Specification in Xenopus by Wnt/β-catenin and TGFβ Signaling Pathways.Dev. Biol. 209: 282-297.
Zorn, AM, Barish, G, Williams, B, Lavander, P, Klymkowsky, M and Varmus, HE (1999) Regulation of Wnt signalling by a Sox protein: XSox17a/b and XSox3 phyically interact with β-catenin.Molecular Cell. 4: 487-498.
Ishikawa, T, Tamai, Y, Zorn, AM, Yoshida, H, Seldin, MF, Nishikawa, S and Taketo, M (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac angiogenesis.Development 128:25-33.
Shimizu, K, Bourillot, P-Y, Nielsen, SJ, Zorn AM and Gurdon JB (2001) Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling.Mol. Cell Biol. 21:
Butler, K, Zorn, AM and Gurdon JB (2001) Non-radioactive in situ hybridisation to Xenopus tissue on sections.Methods. 23 (4): 303-312.
Standley, HJ, Zorn, AM and Gurdon JB (2001) eFGF and its mode of action in the community effect during Xenopus myogenesis.Development 128: 1347-1357.
Zorn AM and Mason J (2001) Gene expression in the embryonic Liver of Xenopus.Mech. Dev. 103: 153-157
Zorn AM (2001) Wnt signalling: Antagonistic Dickkopfs.Current Biology 11: R592-R595
Standley HJ, Zorn AM and Gurdon JB (2002) A dynamic requirement for community interactions during Xenopus myogenesis.Int.J. Dev. Biol. 3: 279-283
Khokha MK, Chung C, Bustamante EL, Gaw LWK, Trott KA, Yeh J, Lim N, Lin JCY, Taverner N, Amaya E, Papalopulu N, Smith JC, Zorn AM, Harland RM, and Grammer TC (2002) Techniques and Probes for the Study of Xenopus tropicalis Development.Dev. Dyn. 225:499-510
D'Souza A, Lee M, Taverner N, Mason J, Carruthers S, Smith JC, Amaya E, Papalopulu N and Zorn AM. (2003) Molecular components of the endoderm specification pathway in Xenopus tropicalis.Dev. Dyn. 226: 118-127
McLin VA and Zorn AM (2003) Organogenesis making pancreas from liver.Cur. Biol. 13: R96-98
Costa JMB, Mason J, Lee M, Amaya E and Zorn AM (2003) Novel gene expression domains reveal early patterning of the Xenopus endoderm.GEP 3: 509-519
Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ-P, Lai D, McDonald LPA, Niederreither K, Dolle P, Bruneau BG, Zorn AM and Harvey RP. (2003) Cardiac T-box factor Tbx20 directly interacts with Nkx2.5, GATA4 and GATA5 in regulation of gene expression in the developing heart.Dev Biol 262: 206-224.
Liu Y, Festing M, Thompson JC, Hester M, Rankin S, El-Hodiri HM, Zorn AM, and Weinstein M (2004). Smad2 and Smad3 coordinately regulate craniofacial and endodermal development.Dev Bio in press.
Sinner D, Rankin S, Lee M and Zorn AM (2004) Sox17 and β-catenin cooperate to regulate the transcription of enododermal genes.Development 131: 3069-3080
Gilchrist M, Zorn AM, Voigt J, Smith JC, Papalopulu N, and Amaya E (2004) Defining a large set of full length clones from a Xenopus tropicalis EST project.Dev Bio 271: 498-516
Daniels M, Shimizu K, Zorn AM, Ohnuma S-I. (2004) Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation.Development 131: 5613-5626.
Maguire ML, Guler-Gane G, Nietlispach D, Raine ARC, Zorn AM, Standart N, Broadhurst RW. (2005) Solution Structure and Backbone Dynamics of the KH-QUA2 Region of the XenopusS TAR/GSG Quaking Protein.J Mol Biol 348: 265-279.
Tao Q, Lloyd B, Lang S, Houston D, Zorn A, Wylie C. (2005) A novel G protein-coupled receptor, related to GPR4, is required for assembly of the cortical actin skeleton in early Xenopus embryos.Development 132: 2825-36.
Park KS, Wells JM, Zorn AM, Wert SE, Laubach VE, Fernandez LG, Whitsett JA. (2005) Transdifferentiation of Ciliated Cells During Repair of the Respiratory Epithelium.Am J Respir Cell Mol Biol 43: 151-157.
Sartor MA, Zorn AM, Schwanekamp JA, Halbleib D, Karyala S, Howell ML, Dean GE, Medvedovic M, Tomlinson CR. (2006) A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus.Nucleic Acids Res Jan 5;34(1):185-200.
Park KS, Wells JM, Zorn AM, Wert SE, Whitsett JA. (2006) Sox17 influences the differentiation of respiratory epithelial cells.Dev Biol 294:192-202.
Sinner D, Kirilenko P, Rankin S, Wei E, Howard L, Kofron M, Heasman J, Woodland HR, Zorn AM. (2006) Global analysis of the transcriptional network controlling Xenopus endoderm formation.Development 133:19555-1966. *This paper was selected by the "Faculty of 1000"
Mir A, Kofron M, Zorn AM, Bajzer M, Haque M, Heasman J, Wylie CC. (2007) FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula. Development. 134:779-88.
McLin VA, Rankin SA, Zorn AM. (2007) Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development.Development 134: 2207-2217.
Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP. (2007) Mutations in cardiac T-box factor TBX20 are associated with diverse cardiac pathologies including defects of septation and valvulogenesis, and cardiomyopathy.Amer Jour Hum Gen 81: 280-291.
Kirilenko P, Weierud FK, Zorn AM, Woodland HR. (2007) Efficiency of primordial Xenopus germ cell migration depends on the germ plasm mRNA encoding the PDZ domain protein Grip2 Differentiation. (in press)
Special Interests
Molecular and cellular mechanisms of embryoinc endoderm development and organ formation.
Presentations
2002 International Xenopus Meeting, Cambridge, UK
2002 EMBO Endoderm Development Meeting, Arolla, Switzerland
2002 University of North Carolina, School of Medicine Seminar Series, Chapel Hill, NC
2003 Ohio State, Children's Hospital Seminar Series, Columbus, OH
2003 Duquesne University Biology Department Seminar Series, Pittsburgh, PA
2003 Cold Spring Harbor, Xenopus Embryology Course NY
2004 Symposium, Genetics and Development of Liver and Pancreas, UCSF, CA
2004 University of Pennsylvania Medical School Seminar Series, Philadelphia, PA
2004 Victor Chan Heart Research Institute Seminar Series, Sydney, Australia
2004 Symposium, GI Stem Cells and Development Mass. General Hospital, Boston, MA
2005 Han-Mo Koo Seminar Series Van Andel Research Institute Grand Rapids, MI
2005 Cold Spring Harbor, Xenopus Course NY
2005 Baylor College of Medicine, Digestive Disease Center, Houston, TX
2005 Digestive Disease Week, Chicago, IL
2005 Child Health Research Institute Seminar Series, London, Ont. Canada
2005 International SOX meeting, Cairns, Australia
2005 Medical College of Wisconsin Seminar Series, Milwaukee, WI
2006 University of Arizona Anatomy Dept. Seminar Series, Tuscon AZ
2006 Cold Spring Harbor, Xenopus Course NY
2006 FASEB Liver meeting Snowmass CO
2006 International Xenopus Meeting, Tokyo, Japan
2006 Chinese Academy of Science, Institute of Zoology, Kunming, China
2006 Johnson & Johnson, Skilman, NJ
2007 Albert Einstein College of Medicine, Liver Center, NY
2007 University of Pennsylvania School of Medicine, Philadelphia, PA
2007 Fox Chase Cancer Center, Philadelphia, PA
2007 Louisville, Birth Defects Center
2008 Keystone Wnt meeting, Keystone CO
2008 International Xenopus meeting, Germany
2008 International Sox meeting, Japan
Related Areas
Member of the strategic committee for the Xenopus tropicalis EST and Genome sequencing project
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
