Find a Health Care Professional / Researcher

Kejian Zhang, MD, MBA

Title

Director, Molecular Genetics Laboratory

Appointment

Assistant Professor of Pediatrics

Email

kejian.zhang@cchmc.org

Phone

513-636-2438

Fax

513-636-2261

Office Location

E5-243 ML 4006

Credentials

MD: Tianjin Medical University, Tianjin, China, 1993

MBA: University of Cincinnati, College of Business Administration, 2001

Residency: Gong'an Hospital, Tianjin, China, 1993-1995

Fellowship: Clinical Molecular Genetics Fellow, Division of Human Genetics, Cincinnati Children's Hospital, 2002-2004

Certification: Clinical Molecular Genetics, certified by the American Board of Medical Genetics in 2005

Awards and Honors

Cecil Boatright Business Plan Competition Award, Sponsored by the Cincinnati Chapter of the Service Corp. of Retired Executives (SCORE) Foundation. University of Cincinnati, College of Business Administration, 2001.

Outstanding Achievement in Promoting the profession of Laboratory Medicine and Research, Awarded by Cincinnati Children's Hospital Medical Center, 2004.

Research

Molecular defects and molecular diagnosis of primary immunodeficiency diseases.

A study entitled "Retrospective Analysis of Correlation between Immunologic Phenotype and Genotype in Patients with Hemophagocytic Lymphohistiocytosis (HLH)" CCHMC IRB #06-05-45 (6/5/2006-6/5/2007)
"Macrophage Activation Syndrome Biomarkers in Systemic JRA" is funded by CCHMC TRI grant 2007-2008.

Genetic aspects of predictive personalized medicine, eg., Pharmarcogenetics.

"Pharmacogenetics of Antiepileptic Drug Efficacy, Metabolism and Toxicity in Children with Epilepsy" (8/8/2003-2008)
"Open-Label Study of the Safety, Tolerability and Efficacy of Individualized Selective Serotonin Reuptake Inhibitor Dosing During Acute Treatment for Adolescents with Depression Based on Cytochrome P450 2D6 and 2C19 Genotype" (8/3/2006-2007)
"Pharmacogenetics of Mycophenolic Acid in Kidney Transplant Patients" (on-going). CHMC#06-06-44
"Effect of genetic pharmacology service's Psychiatry panel: retrospective chart review" ( Study period Jan 1, 2000 to Sep 30, 2005)
"Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid", this is funded by CCHMC Translational Research Initiative (TRI) grant 2007-2008

Other research activities:

"Fanconi Anemia SeqChip" development. Serves as consultant in design and implement a comprehensive "Fanconi Anemia SeqChip" consisting of a single Affymetrix resequencing chip that will facilitate rapid, reproducible and cost-effective diagnostic sequence analysis of FA-causing genes as well as distinction of FA from other chromosome breakage/bone marrow failure syndromes.

Publications, Most Recent

Peer-Reviewed Publications

Lee, D.W.; Zhang, K.; Ning, Z.; Raabe, E.H.; Tintner, S.; Wieland, R.; Wilkins, B.J.; Kim, J.M.; Blough, R.I.; Arceci, R.J.: PASG: An SNF2 Family Member Altered in Leukemia.Cancer Res, 2000 Jul 1; 60(13):3612-3622.

Molleran Lee, S.; Villanueva, J.; Sumegi, J.; Zhang, K.; Kogawa, K.; Davis, J.; Filipovich, A.H.: Characterization of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with Hemophagocytic Lymphohistiocytosis.Journal of Medical Genetics, 2004; 41:137-144.

Tabata, Y.; Villanueva, J.; Molleran Lee, S.; Zhang, K.; Kanegane, H.; Miyawaki, T.; Sumegi, J.; Filipovich, A.H.: Rapid detection of intracellular SH2D1A protein in Cytotoxic Lymphocytes from Patients with X-linked Lymphoproliferative Disease and their Family members.Blood, April 15, 2005; 105(8):3066-3071.

Sumegi, J.; Johnson, J.; Filipovich, A.; Zhang, K.: Lymphoproliferative Disease, X-Linked.In: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2004; Available at http://www.genetests.org.

Filipovich, A.; Johnson, J.; Zhang K.: Wiskott-Aldrich syndrome and related disorders.In: GeneReviews at GeneTests:Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2004; Available at http://www.genetests.org.

Zhang, K.; Filipovich, A.H.; Johnson, J.: Hemophagocytic Lymphohistiocytosis, Familial. In: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2006. Available at http://www.genetests.org.

Sumegi, J.; Johnson, J.; Filipovich, A.; Zhang, K.: Lymphoproliferative Disease, X-Linked.In: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle. 1997-2006. Available at http://www.genetests.org.

Lee, S.M.; Sumegi, J.; Villanueva, J.; Tabata, Y.; Zhang, K.; Chakraborty, R.; Sheng, X.; Clementi, R.; de Saint Basile, G.; Filipovich, A.H.: Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation.J Pediatr, July 2006; 149(1):134-137.

Bleesing, J.; Johnson, J.; Zhang, K.: Autoimmune Lymphoproliferative Syndrome.In: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2006. Available at http://www.genetests.org.

Zhang, K.; Johnson, J.A.; Biroschak, J.; Villanueva, J.; Lee, S.M.; Bleesing, J.J.; Wenstrup, R.J.; Filipovich, A.H.: The A91V substitution in the Perforin 1 (PRF1) gene is found in patients with Familial Hemophagocytic Lymphohistiocytosis (FHL) in combination with other PRF1 or Munc13-4 mutations.International Journal of Immunogenetics, 2007.

Johnson, J.; Filipovich, A.; Zhang, K.: Hyper IgM Immunodeficiency, X-Linked.In: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2007. Available at http://www.genetests.org.

Presentations, Most Recent

PASG: An SNF2 Family Member Altered in Leukemia. Presented to the 42nd American Society of Hematology Annual Meeting; 2001.

Gene Expression Profiles of Human Circulating and In Vitro Expanded CD8+ CTLs. Presented to the 43rd American Society of Hematology Annual Meeting; 2002.

Population studies of three X-linked Immunodeficiency Diseases and Genotype-Immunophenotype correlations of PRF1 mutations in Familial Hemophagocytic Lymphohistiocytosis. Presented to the 53rd Annual Meeting of American Society of Human Genetics; 2003.

NK Dysfunction and Depressed Perforin Expression Associated with the A91V Genetic Variant of PRF1. Presented to the American Histiocyte Society meeting, 2004.

A New Method for Mutation Analysis in Patients with Wiskott-Aldrich Syndrome (WAS) and Related Disorders. Presented to the 54rd Annual Meeting of American Society of Human Genetics, 2004.

Rapid detection of SLAM Associated Protein (SAP) deficiency by flow cytometry in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease (XLP). Presented to the Histiocyte Society 20th Annual Meeting, Congress of European Histiocyte Society; 2004.

Rapid detection of SAP deficiency in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members. Presented at the American Society of Hematology meeting; 2004.

Heterozygous inheritance of the A91V genetic variant of PRF1: is it related to disease susceptibility? Presented at the Congress of European Histiocyte Society; 2004.

Characterization of herpsvirus saimiri-transformed cytotoxic T lymphocytes from patients in perforin or SAP/SH2D1A deficiency. Presented at the Congress of European Society of Immunodeficiencies; 2005.

PRF1 and Munc13-4 Mutations in North American Patients with Familial Hemophagocytic Lymphohistiocytosis. Presented at the Meeting of the American Society of Human Genetics; 2006; New Orleans, LA.

Resent Advances in the Molecular Diagnoses of Inherited Immunodeficiencies: Implications for Genetic Counselors (education breakout session). Presented at the 23rd Annual Education Conference by National Society of Genetic Counselors, Inc.

Heterozygosity of A91V-PRF1 in patients with Familial Hemophagocytic Lymphohistiocytosis. Presented at the Congress of European Society of Immunodeficiencies; 2006; Budapest, Hungary.

Molecular mechanisms of Non-Mendelian Inheritance. Presented at the genetic counseling program of 2006-2007 in the College of Medicine and University of Cincinnati.