Find a Health Care Professional / Researcher

Clinton H. Joiner, MD, PhD

Title

Director, Sickle Cell Center

Appointment

Professor of Pediatrics, Molecular and Cellular Physiology

Email

clinton.joiner@cchmc.org

Phone

513-636-4541

Fax

513-636-5562

Credentials

MD: Duke University School of Medicine, Durham, NC, 1977.

PhD: Physiology and Pharmacology, Duke University Durham, NC, 1977.

Residency: Pediatrics, Duke University Medical Center, Durham, NC.

Fellowship: Neonatology, Children's Hospital, Harvard Medical School, Boston, MA.

Certification: General Pediatrics, American Academy of Pediatrics, 1983, sub-board in Neonatal/Perinatal Medicine, American Academy of Pediatrics, 1983.

Awards and Honors

Fellow, American Academy of Pediatrics Medical
Scientific Advisory Committee, Sickle Cell Disease Association of America
Ad Hoc member, Erythrocyte, Leukocyte Biology Study Section, National Heart, Lung, and Blood Institute (NHLBI)
Chair, Steering Committe of the National Institute of Health (NIH) Comprehensive Sickle Cell Centers
Editorial Board, American Journal of Hematology
Hemoglobinopathies Coordinating Committee, National Heart Lung and Blood Institute

Research Grants and Contracts

National Heart Lung and Blood Institute: Cincinnati Comprehensive Sickle Cell Center U54 HL070871; 4/1/03-3/31/08. C. H. Joiner, Program Director.

National Institute of Diabetes Digestive & Kidney Disease: Research Grant R01 DK63088. The Glycosylation Gap and Diabetic Complications, RM Cohen, P.I. 9/30/02-8/31/06, C.H. Joiner Co-Investigator.

Health Resources and Services Administration, United States Public Health Service. H46MC00252-01 Improving Hemoglobinopathy Screening Follow-up and Services for Affected Families in Cincinnati. Nona Cahoun-Mumia, P.I, Co-Investigator: C. H. Joiner, Co-I.

Publications, Most Recent

Connect to Clinton Joiner's publications on PubMed

Joiner, C.H.; Rettig, R.K.; Jiang, M.; Risinger, M.; Franco, R.S.: Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes.Blood, 109(4):1728-35, 2007.

Goodman, S.R.; Joiner, C.H.: Damage to the RBC Membrane in Sickle Cell Disease.In The Renaissance of Sickle Cell Disease Research in the Human Genome Era, B Pace, Ed. Imperial College Press, UK, 2006.

Kalfa, T.A.; Pushkaran, S.; Narla, M.; Hartwig, J.H.; Johnson, J.F.; Joiner, C.H.; Williams, D.A.; Zheng, Y.: Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.Blood, 108(12):3637-45, 2006.

Franco, R.S.; Yasin, Z.; Palascak, M.B.; Ciraolo, P.; Joiner, C.H.; Rucknagel, D.L.: Effect of Fetal Hemoglobin on the Survival Characteristics of Sickle Cell.Blood, 108(3):1073-6, 2006.

Crable, S.C.; Hammond, S.M.; Papes, R.; Rettig, R.K.; Zhou, G.P.; Gallagher, P.G.; Joiner, CH.; Anderson, K.P.: Multiple isoforms of the KCI cotransporter are expressed in sickle and normal erythroid cells. Exp. Hematology, 33:624-31, 2005.

Joiner, CH, RK Rettig, M Jiang, and RS Franco. KCl Cotransport Mediates Abnormal, Sulfhydryl-Dependent Volume Regulation in Sickle Reticulocytes.Blood, 2004 Nov 1;104(9):2954-60.

Cohen, RM, RS Franco, and CH Joiner. Is poor glycemic control associated with reduced red blood cell lifespan? Invited Editorial, Diabetes Care, 2004 Apr;27(4):1013-4.

Yasin, Z, S Witting, MB Palascak, CH Joiner, DL Rucknagel, and RS Franco. Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F.Blood, 2003 Jul 1;102(1):365-70.

Merciris, P, WJ Claussen, CH Joiner, and F Giraud. Regulation of K-Cl Cotransport by Syk and Src protein tyrosine kinase. Eur.J.Physiol, 446:232-238, 2003.

Cohen, RM, YR Holmes, TC Chenier, and CH Joiner. Discordance between HbA1c and Fructosamine: Evidence for a glycosylation gap and its relation to diabetic retinopathy.Diabetes Care, 26:163-7, 2003.

JD Holtzclaw, M Jiang, Z Yasin, CH Joiner, and RS Franco. Rehydration of high-density sickle erythrocytes in vitro.Blood, 100:3017-3025, 2002.

Professional Organization Memberships

Sigma XI
American Physiological Society
American Society for Hematology
American Academy of Pediatrics
Cincinnati Pediatric Society
Society of General Physiologists
American Pediatric Society
American Society for Pediatric Hematology/Oncology

Abstracts

CH Joiner, R Papes, S Crable, D Pan, and DB Mount: Functional Comparison of Red Cell KCl Cotransporter isoforms, KCC1, KCC3, and KCC4. Presented at American Society of Hematology, Orlando, FL; December 2006.

CH Joiner, S Crable, and PG Gallagher: Alternative Splicing within Exon 1 of the KCl Cotransporter-3 (KCC3) Gene Results in Novel Transcripts in Erythroid Cells. Presented at American Society of Hematology, Orlando, FL; December 2006.

CH Joiner, R Papes, M Jiang, and S Crable: Kinetic characteristics of KCl Cotransporter isoforms, KCC1, KCC3, and KCC4, expressed in HEK 293 cells. Presented at National Sickle Cell Meetings, Memphis, TN; April 2006.

CH Joiner, RK Rettig, M Jiang, and RS Franco: KCl Cotransport Mediates Abnormal Volume Regulation in Sickle Reticulocytes. Presented at National Sickle Cell Meetings, Memphis, TN; April 2006.

CH Joiner, S Crable, K Anderson, S Hammond, and P Gallagher: Expression of a KCl Cotransporter (KCC1) Splice Variant is Suppressted by TNFa and NF-kB in Erytroid Cells. Presented at National Sickle Cell Meetings, Memphis, TN; April 2006.

CH Joiner, RK Rettig, M Palascak, A Sheriff, RM Cohen, and RS Franco: Mature Sickle Cell and Normal Red Cells Exhibit Regulatory Volume Decrease Activated by Urea and Mediated by KCI Cotransport. Presented at American Society of Hematology, Atlanta, GA; December 2005.

CH Joiner: Volume Regulation in Sickle and Normal Reticulocytes. Presented at the Red Cell Club Symposium, University of Illinois - Chicago; September 2005.

RS Franco, M Palascak, P Ciaralo, K Rettig, Z Yasin, and CH Joiner: Sickle Cell Patients with a Higher Percentage of HbF-Containing RBC (F Cells) Have Shorter Survival of RBC that Lack HbF. Presented at American Society of Hematology, San Diego, CA; December 2004.

CH Joiner, K Rettig, M Jiang, and RS Franco: Activation of KCI Cotransport by Urea Induces Dehydration in Both Sickle and Normal Reticulocytes. Presented at American Society of Hematology, San Diego, CA; December 2004.

CH Joiner, M.D., PhD., Kirk Rettig, B.S., Maorong Jiang, M.D., Robert S. Franco, PhD., (Oral presentation) KCI Cotransport Mediates Abnormal Suflhydryl-Dependent Regulatory Volume Decrease In Sickle Reticulocytes. National Sickle Cell Meeting, Los Angeles, CA., April, 2004.

Lori E. Crosby, PhD., Julia Bloom, B.S., Monica Mitchell, PhD., Patricia Pearl, Annette Lavendar, MSN, FNP, Patrick Kelly, M.D., CH Joiner, M.D., PhD., (Oral presentation) Healthbeat: Health Beliefs and Attitudes of Teens and Young Adults with SCD. National Sickle Cell Meeting, Los Angeles, CA., April, 2004.

Pamela Jenkins, M.S., LSW, Lori E. Crosby, PhD., Belinda B.S. LSW, Nona Calhoun-Mumia, M.S., CHES, Reginald Willis, B.S., CH Joiner, M.D. PhD., (Oral presentation) Y Stress, Eustress, Know Stress Parent Support Group. National Sickle Cell Meeting, Los Angeles, CA., April, 2004.

CH Joiner, M.D., PhD., Kirk Rettig, B.S., Maorong Jiang, M.D., Robert S. Franco, PhD., (Oral presentation) Sickle Cells Exhibit Abnormal, Sulfhydryl-Dependent KCI Cotransport Activation by Acid pH and Urea, But Normal Activation by Cell Swelling. National Sickle Cell Meeting, Los Angeles, CA., April, 2004.

Robert S. Franco, PhD., PeterCiraolo, M.S., Mary B. Palascak, B.S., CH Joiner, M.D., PhD., Dense Sickle Cells Contain Decreased Amounts of the Calpain Inhibitor Calpastatin. (Oral presentation), National Sickle Cell Meeting, Los Angeles, CA., April, 2004.

Monica Mitchell, PhD., Kathy Lemanek, PhD., Tonya Palermo, PhD., Lori Crosby, PhD., .Julia Bloom, B.A., Janelle Hines, B.A., CH Joiner, M.D., PhD,. Scott Powers, PhD., Living with Sickle Cell Disease: Coping and Resiliency in Patients, Parents and Siblings. (Poster presentation), National Sickle Cell Meeting, Los Angeles, CA., April, 2004.

CH Joiner, RK Rettig, M Jiang, RS Franco. KCl Cotransport Regulation by Cell Volume, pH and Urea is Abnormal in Sickle Red Blood Cells. Presented at American Society of Hematology, San Diego, December, 2003.

CH Joiner, M.D., Ph.D., R.K. Rettig, B.S., and R.S. Franco, Ph.D. The Volume Set Point of KCl Cotransport in Sickle and Normal Reticulocytes: Effects of Cell Age and Sulfhydryl Reduction. (Oral presentation), National Sickle Cell Meetings, Washington DC, September, 2002.

R.S. Franco, Ph.D., Z. Yasin, M.D., CH Joiner, M.D., Ph.D., and D.L. Rucknagel, M.D., Ph.D. High Sodium Sickle Cells from the Low Density Fraction Have a Very Short In Vivo Survival. Oral presentation, National Sickle Cell Meetings, Washington DC, September, 2002.

K.P. Anderson, Ph.D., S.C. Crable, M.S., A. Hull, B.S. and CH Joiner, M.D., Ph.D., Expression of Multiple KCl Cotransport Isoforms in Sickle and Normal Erythroid Cells. Oral presentation, National Sickle Cell Meetings, Washington DC, September, 2002.

R.S. Franco, Ph.D., J.D. Holtzclaw, Ph.D., and CH Joiner, M.D., Ph.D. Sickle Cell Dehydration Revisited: Evidence for Pathological Rehydration of Dense Cells. (Poster presentation), National Sickle Cell Meetings, Washington DC, September, 2002.