Find a Health Care Professional / Researcher

Andrew D. Hershey, MD, PhD

Title

Director, Headache Center

Appointment

Associate Professor of Pediatrics and Neurology

Email

neuro@cchmc.org

Phone

513-636-4222

Fax

513-636-3980

Bio

Andrew Hershey, MD, PhD, received his undergraduate degree at the University of Iowa, Iowa City, Iowa. He earned an honors degree in Biochemistry; hiss research involved the enzyme kinetic properties of alcohol dehydrogenase in yeast.

After undergraduate school, Dr. Hershey attended the MD/PhD program at Washington University, St. Louis, Missouri. His Ph.D. research thesis was entitled: "The Rat Substance P Receptor: cDNA and Genomic Cloning, Functional Expression, mRNA Distribution, and Mutational Analysis of Desensitization Responses."

After earning his MD and PhD, Dr. Hershey was an intern and resident in pediatrics at St. Louis Children's Hospital, St. Louis, Mo. He then was an adult neurology resident at Barnes-Jewish Hospital, St. Louis, Mo., followed by his child neurology fellowship at St. Louis Children's Hospital, St. Louis, Mo.

After his fellowship, Dr. Hershey joined the faculty at Cincinnati Children's Hospital Medical Center, Ohio, where he is director of the Headache Center.

Dr. Hershey's research interests currently include the improved diagnosis and treatment of childhood headache disorders, characterization of outcome responses, studies in new pharmacological and non-pharmacological treatment regimes, and the neurogenetics of migraines.

Credentials

MD: Washington University, St. Louis, Mo., 1992

PhD: Washington University, St. Louis, Mo., 1992

BS: University of Iowa, Iowa City, Iowa, 1985

Residency: Pediatrics, St. Louis Childrens Hospital, St. Louis, Mo., 1993-1994; Neurology, Barnes-Jewish Hosptial, St. Louis, Mo.,1994-1995

Fellowship: Child Neurology , St. Louis Childrens Hospital, St. Louis, Mo., 1995-1997

Certification: Neurology with special competence in child neurology, 1998

Awards and Honors

2001/2002 Strathmore's Who's Who, 2001-2002 Millennium Edition
2000 Lexington Who's Who
1997 1997 Annual Meeting Scholarship for Residents
1992 Spencer T. and Ann W. Olin Medical Scientist Fellow
1991 James L. O'Leary Prize for Research in Neuroscience
1985 Honors Certificate of Achievement
1984 to 1985 Ernest R. Johnson Memorial Prize
1984 to 1985 Student Research Fellowship, University of Iowa
1982 to 1984 Scholastic Citation List
1984 to 1985 Univ. of Iowa President's List
1983 to 1985 Univ. of Iowa Dean's List
1982 to 1984 National Dean's List
1983 Dewey B. Stuit Scholarship for Honors Sophomore
1983 University of Iowa Foundation Honors Award
1982 Dewey B. Stuit Freshman Award
1982 Phi Eta Sigma Freshman Honors Society
1981 to 1985 Maytag Company Foundation Award

Research

Epidemiology; diagnositic criteria; treatment evaluation; outcome responses; quality of life issues; pharmaceutical trials; and neurogenetics of childhood headaches.

Research Grants and Contracts

R01 NS045752 Hershey (PI)
07/01/03 - 06/30/07
NIH/NINDS
Genomics of Pediatric Headache Disorders
The aim of this study is to determine whether acute and chronic daily headache patients have similar or different blood genomic profiles.

R01 NS050536 Powers (PI) 07/01/06 - 06/30/10
NIH/NINDS
Drug & Non-Drug Treatment of Pediatric Chronic Headache
Clinical trial to test the efficacy of combined behavioral and pharmacological treatment for youth with chronic headache on two primary endpoints: headache frequency and functional disability.
Role: Co-investigator

American Headache Society, Hershey (PI)
03/01/01 - 06/30/07
Multi-center characterization of pediatric headache - year 1
Longitudinal outcome of pediatric headache and analysis of established criteria - year 2
Obesity in pediatric migraine - year 3
Longitudinal Outcome of Pediatric Chronic Daily Headache - year 4
The aims of these studies are to better characterize pediatric headache using a multi-specialty center approach.
Role: Co-investigator (year 1 and 2), Principal investigator (year 3 and 4)

UCB Pharmacia, Hershey (PI)
10/01/02 - 6/30/07
A retrospective evaluation of the responsiveness of childhood migraines to treatment with levetiracetam.

Tishcon, Inc.
11/01/04 - 06/30/07
CoEnzyme Q10 Supplementation in the Prevention of Childhood Headache
This investigator initiated study is a double blind, placebo-controlled, cross-over study examining the effects of the supplementation with CoEnzyme Q10 on pediatric headache.

Abbott Laboratories Hershey (PI)
8/03 to 5/05 (study site), 8/03 to 5/07 (PedMIDAS)
The Safety and Efficacy of Divalproex Sodium Extended-Release Tablets in Migraine Prophylaxis: A Double-Blind, Placebo-Controlled Study in Adolescents (M02-488)
Role: Local PI and consultant to Abbott Laboratories for study design (PedMIDAS)

Publications, Most Recent

Winner, P and Hershey, AD. Diagnosing Migraine in the Pediatric Population.Curr Pain Headache Rep 10:363-369 2006.

Hershey, AD, Kabbouche, MA, and Powers, SW. Chronic Daily Headaches in Children.Curr Pain Headache Rep 10:370-376 2006.

Powers, SW, Gilman, DK, and Hershey, AD. Headache and Psychological Functioning in Children and Adolescents.Headache 46:1404-1415 2006.

Powers, SW, Gilman, DK, Hershey, AD and the Headache Center at Cincinnati Children's Hospital Medical Center. Clinical Pearl/Brief Report: Suggestions for a Biopsychosocial Approach to Treating Children and Adolescents who Present with Headache.Headache 46:S149-150 2006.

Sharp, FR, Lit, L, Xu, H, Apperson, M, Walker, W, Wong, B, Gilbert, DL, Hershey, A and Glauser, TA. Genomics of Brain and Blood: Progress and Pitfalls.Epilepsiz 47:1603-1607 2006.

Sharp, FR, Xu, J, Lit, L, Walker, W, Apperson, M, Gilbert, DL, Glauser, TA, Wong, B, Hershey, AD, Liu, D-Z, Pinter, J, Zhang, X, Liu, X, and Ran, R. The Future of Genomic Profiling of Neurological Diseases Using Blood.Arch Neurol 63:1-8 2006.

Hershey AD: Treatment of Pediatric and Adolescent Headaches.Curr. Treat. Options Neurol. 7:459-467 2005.

Hershey AD: Pediatric Headache.Pediatric Annals (Guest Editor) 34:426-429 2005.

Hershey AD: What is the Impact, Prevalence, Disability and Quality of Life of Pediatric Headache?Current Pain and Headache Reports 9:341-344 2005.

Hershey AD, Winner P, Kabbouche MA, Gladstein J, Yonker M, Lewis D, Pearlman E, Linder SL, Rothner AD, Powers SW: Use of the ICHD-II Criteria in the Diagnosis of Pediatric Migraine.Headache 45:1288-1297 2005.

Hershey AD, Winner PK: Pediatric Migraine: Recognition and Treatment.J. Am. Osteopathic Assoc. 105 (Suppl. 2):S2-S8 2005.

Kabbouche MA, Powers SW, Vockell A-LB, LeCates SL, Ellinor PL, Segers A, Manning P, Hershey AD: Outcome of a Multidisciplinary Approach of Pediatric Migraine at 1, 2, and 5 Years.Headache 45:1298-1303 2005.

Tang Y, Gilbert D, Glauser TA, Hershey AD, Sharp FR: Blood Gene Expression Profiling of Neurological Diseases - A Pilot Microarray Study.Arch. Neurol. 62(2):210-215 2005.

Lewis D, Ashwal S, Hershey AD, Hirtz D, Yonker M, Silberstein S: Practice Parameter: Pharmacological Treatment of migraine headache in children and adolescents.Neurology 63: 2215-2224 2004.

Tang Y, Schapiro MB, Franz DN, Patterson BJ, Hickey FJ, Schorry EK, Hopkin RJ, Wylie M, Narayan T, Glauser TA, Gilbert DL, Hershey AD, Sharp FR: Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and down's syndrome.Ann Neurol. 56(6):808-14 2004.

Tang Y, Hershey AD, Powers SW, Gilbert D, Glauser TA, Sharp FR: Genomic Abnormalities in Patients with Migraine and Chronic Migraine: Blood Gene Expression Evidence of Platelet Abnormalities.Headache 44(10):994-1004, 2004.

Tang Y, Lu A, Ran R, Arnow BJ, Schorry EK, Hopkin RJ, Gilbert DL, Glauser TA, Hershey AD, Richtand NW, Privitera MD, Dalvi A, Sahoy A, Szaflarski JP, Ficker DM, Ratner N, Sharp FR: Human Blood Genomics: Distinct Profiles for Gender, Age and Neurofibromatosis Type 1.Mol. Brain Res. 132(2):155-67, 2004.

Hershey AD, Powers SW, Vockell A-LB, LeCates SL, Segers A, Kabbouche MA: Development of a Patient-based Grading Scale for PedMIDAS. Cephalagia 24(10): 844–849, 2004.

Powers SW, Patton SR, Hommel KA, Hershey AD: Quality of Life in Pediatric Migraine: Characterization of Age-related Effects Using PedsQL 4.0.Cephalalgia 24:120-127, 2004.

Tang Y, Glauser TA, Gilbert DL, Hershey AD, Privitera MD, Ficker DM, Szaflarski JP, Sharp FR: Valproic acid blood genomic expression patterns in children with epilepsy – a pilot study.Acta Neurol Scand 109:159-168, 2004.

Hershey AD: Chronic Daily Headaches in Children.Expert Opin. Pharmacother. 4:485-491 2003.

Powers SW, Patton SR, Hommel KA, Hershey AD: Quality of Life in Pediatric Migraines: Clinical Impact and Comparison to Other Chronic Illness.Pediatrics, 112:e1-e5, 2003.

Kabbouche MA, Powers SW, Vockell A-LB, LeCates SL, Hershey AD: Carnitine Palmytoyltransferase Deficiency (CPT) and Migraine Headaches.Headache 43:490-495, 2003.

Miller VA, Palermo TM, Powers SW, Scher MS, Hershey AD: Migraine Headaches and Sleep Disturbances in Children.Headache 43:362-368 2003.

Hershey AD, Powers SW, Vockell A-LB, LeCates SL, Kabbouche MA: Effectiveness of Topiramate in the Prevention of Childhood Headaches.Headache 42:810-818, 2002.

Koenig MA, Gladstein J, McCarter RJ, Hershey AD, Wasiewski W, Pediatric Committee of the American Headache Society: Chronic Daily Headache in Children and Adolescents Presenting to Tertiary Headache Clinics.Headache 42:491-500 2002.

Professional Organization Memberships

Ohio Headache Association, 2005 to present
American Academy for the Advancement of Science, 2000 to present
Child Neurology Society, 1999 to present
American Headache Society, 1998 to present
International Headache Society, 1998 to present
American Academy of Neurology, 1997 to present
American Academy of Pediatrics, 1992 to present
Society for Neuroscience, 1990 to 1997
American Medical Association, 1985 to 1992
American Medical Student Association, 1985 to 1992
Sigma Xi, Scientific Research Society, 1985

Teaching

"Childhood Headaches: History and Diagnosis" Childhood Headache: School Management at Hamilton County Education Service Center, March 16, 2000.

"Pharmacological Management of Headaches in Children" Childhood Headache: School Management at Hamilton County Education Service Center, March 16, 2000.

"Migraine Management in the Pediatric Patient" Western New York Pediatric Association and Buffalo Pediatric Society, November 16, 2000. Buffalo, New York.

"Management of Pediatric Headache" Children's Hospital of Alabama, University of Alabama, Birmingham, February 1, 2001. Birmingham, Alabama.

"Migraine Classification, Evaluation and Disability" presented as part of Pediatric Migraine Advances and Controversies, Alfred I. DuPont Hospital for Children, The Nemours Foundation, November 16, 2001. Wilmington, Delaware.

"Headaches" Ohio/Kentucky Outreach Series, Cincinnati's Children's Hospital Medical Center, March 14, 2002, March 21, 2002. Cincinnati, Ohio.

"Counterpoint on Special Issues" The 10th Congress of the International Headache Society, June 29, 2001. New York City, New York.

"Treating Migraine Headaches in Children and Adolescents" The 2001 Annual Meeting of the American College of Clinical Pharmacy, October 22, 2001. Tampa, Florida.

Abstracts

Hershey AD, Winner P, Burstein R, Kabbouche MA, Powers SW: Awareness of Allodynia during Migraine in Children and Adolescents: Identification and Characterization. Presented at the 47th Annual Scientific Meeting of the American Headache Society, June 23 - June 26, 2005, Philadelphia, PA.

Kabbouche MA, Hershey AD, Powers SW, LeCates SL, Ellinor PL, Segers A, Vockell A-LB, Manning P, Linder SL: Botulinum Toxin A in the Treatment of Migraine Headache in Children. Presented at the 47th Annual Scientific Meeting of the American Headache Society, June 23 - June 26, 2005, Philadelphia, PA.

Hershey AD, Winner P, Kabbouche MA, Gladstein J, Yonker M, Lewis D, Pearlman E, Linder SL, Rothner AD, Powers SW: Pain severity assessment in pediatric headache: Comparison of numerical and categorical rating scales. Presented at the 47th Annual Scientific Meeting of the American Headache Society, June 23 - June 26, 2005, Philadelphia, PA.

Powers SW, Piazza-Waggoner C, Malblanc R, Kashikar-Zuck S, Kabbouche MA, LeCates S, Ellinor P, Vockell A, Segers A, Manning P, Hershey AD: A pilot study of amitriptyline combined with coping skills training for youth with chronic daily headache: Impact on headache frequency, severity, and functional disability. Presented at the 47th Annual Scientific Meeting of the American Headache Society, June 23 - June 26, 2005, Philadelphia, PA.

Lewis DW, Ashwal S, Hershey AD: Practice parameter: Pharmacological treatment of migraine headache in children and adolescents. Report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Presented at the 47th Annual Scientific Meeting of the American Headache Society, June 23 - June 26, 2005, Philadelphia, PA.

Kabbouche MA, Powers SW, Vockell A-LB, LeCates SL, Ellinor PL, Segers A, Manning P, Burdine D, Chmelik EA, Hershey AD: Screening tool for migraine in school age children and adolescents. Presented at the 47th Annual Scientific Meeting of the American Headache Society, June 23 - June 26, 2005, Philadelphia, PA.

Winner P, Lewis D, Hershey AD, Wasiewski W: Unique study design demonstrates that zolmitriptan 5 mg nasal spray is effective and well tolerated in the acute treatment of adolescent migraine. Presented at the 47th Annual Scientific Meeting of the American Headache Society, June 23 - June 26, 2005, Philadelphia, PA.

Hershey AD, Winner P, Lewis D, Wasiewski W: Zolmitriptan 5 mg nasal spray is effective and well tolerated in the acute treatment of adolescent migraine. Presented at the XII Congress of the International Headache Society/IHC 2005, October 9-12, 2005 Kyoto, Japan, Cephalalgia 25:899 2005.

Khurana Hershey GK, Stevenson M, Grube E, Hershey AD: Characterization of headache presenting to a tertiary allergy clinic. Presented at the XII Congress of the International Headache Society / IHC 2005, October 9-12, 2005 Kyoto, Japan, Cephalalgia 25:1004-1005 2005.

Hershey AD, Powers SW, Kabbouche MA, Burdine D, Glauser TA, Tang Y, Sharp FR: Genomic profiles in patients with chronic migraine: responders vs. non-responders. Presented at the XII Congress of the International Headache Society/IHC 2005, October 9-12, 2005 Kyoto, Japan, Cephalalgia 25:852-853 2005.

Ran R, Tang Y, Du X, Franz D, Schapiro M, Gilbert D, Hershey AD, Glauser TA, Xu H, Lit L, Lu A, Sharp FR: Autism Related Genes Regulated in Blood of Tuberous Sclerosis Patients: Genomic Analysis Using Microarrays. Presented at the Society for Neuroscience 35th Annual Meeting, November 12-16, 2005. Washington, DC.

Books

Rothner, A. D. and Hershey, A. D. "Secondary Headaches" in Headache in Children and Adolescents: A Practicing Physician's Approach. Eds. Winner, P. and Rothner, A.D. B.C. Decker, Hamilton, Ontario, Canada. 2000.

Hershey, A. D. and Powers, S. W. "Abortive Therapy for Migraine" in Current Management in Child Neurology, 2nd Edition, Ed. Maria, B. L., B.C. Decker, Hamilton, Ontario, Canada. 2001.

Powers, S. W. and Hershey, A. D. "Biofeedback for Childhood Migraine" in Current Management in Child Neurology, 2nd Edition, Ed. Maria, B. L., B.C. Decker, Hamilton, Ontario, Canada. 2001.