Rashmi S. Hegde, PhD
Appointment
Associate Professor, University of Cincinnati College of Medicine
Email
rashmi.hegde@chmcc.org
Phone
513-636-5947
Fax
513-636-6772
Bio
Rashmi Hegde received her PhD in Medicinal Chemistry from the University of Pittsburgh in 1989. She received post-doctoral training in the Department of Molecular Bioophysics and Biochemistry at Yale University, where she was a fellow of the National Cancer Center. She was appointed Assistant Professor of Biochemistry at New York University School of Medicine and the Skirball Institute of Biomolecular Medicine in 1994. She is presently a tenured Associate Professor in the Deparment of Pediatrics, University of Cincinnati and Division of Developmental Biology at Childrens Hospital Research Foundation.
Credentials
PhD: University of Pittsburgh, Pittsburgh, PA, 1989
Post-doctoral Fellowship: Yale University, 1989-1994
Assistant Professor: New York University School of Medicine, Skirball Institute, 1994-2000
Awards and Honors
1993 National Cancer Center post-doctoral fellowship
1994 American Cancer Society Institutional Research Grant
1995 Whitehead Presidential Research Fellowship for Junior Investigators
1999 Dean's Recognition Citation for Excellence in Medical Education, NYU Med. Center
Research
Visit the Hegde Lab Site.
Molecular mechanisms underlying early stages in embryonic organ development, molecular basis of developmental defects and cancer, protein-DNA interactions, X-ray crystallography
Research Grants and Contracts
Mechanism of Action of Retinal Determination Proteins
Type: RO1 (2004 - 2009) EY014648
Role on Project: PI
DNA Target Selection by Papillomavirus E2 Proteins
Crystallographic studies of the papillomavirus E2 proteins and their complexes with DNA.
Type: R01 (1996-2006) CA66964
Role on Project: PI
Indirect Readout Mediation of Protein-DNA Interactions
Type: R01 (2001-2005) GM63582
Role on Project: Co-PI
Publications, Most Recent
Rashmi Hegde's publications as listed by PubMed
Hegde RS. The papillomavirus E2 proteins: Structure, Function and Biology. (2002) Annual Reviews of Biophysics and Biomolecular Structure 31:343-360
Kim SS, Braunstein SE, Zhang RG, Joachimiak, A, Cvekl A, Hegde RS. (2002) Structure of the retinal determination protein Dachshund reveals a DNA binding motif.Structure 10:787-795.
Rayapureddi JP, Kattamuri C, Steinmetz BD, Frankfort BJ, Ostrin EJ, Mardon G, Hegde RS. (2003) Eyes Absent represents a class of protein tyrosine phosphatases.Nature 426(6964):295-298 (News and Views, Nature (2003) 426(6964):238-9).
Zhang Y, Xi A, Hegde RS, Shakked Z, Crothers DM. (2004) Predicting indirect readout effects in protein-DNA interactions.Proceedings of the National Academy of Sciences 101(22):8337-41.
Wilson J, Malakhova M, Zhang RG, Joachimiak A, Hegde RS. (2004) Crystal structure of the Dachshund-homology domain of human SKI.Structure 12(5):785-792
Tan M, Hegde RS, Jiang J. (2004) The P domain of norovirus capsid protein forms a dimer and binds to histo-blood group antigen receptor.Journal of Virology 78(12):6233-42
Rayapureddi JP, Kattamuri C, Chan FH, Hegde RS. (2005) Characterization of a plant, tyrosine-specific phosphatase of the aspartyl class.Biochemistry 44(2):751-8
Teaching
Join members of the Visual Systems Research Group for the The Great Lakes and Abrahamson Pediatric Eye Institute Vision Research Conference, November 11-12, 2005. Learn more about this conference here.
Special Interests
Research in the Hegde Laboratory is aimed at understanding the structural basis for specificity in macromolecular interactions. Currently the two main areas of interest in the laboratory are:
- proteins involved in early vertebrate development
- proteins involved in the life- and infection-cycles of the cancer-associated papillomaviruses.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
