Marc E. Rothenberg, MD, PhD
Title
Director Allergy and Immunology
Appointment
Professor of Pediatrics
Email
marc.rothenberg@cchmc.org
Phone
513-636-7210
Fax
513-636-3310
Credentials
MD, PhD: Harvard Medical School, Cambridge, Mass., 1990.
Residency: Pediatrics, Children's Hospital, Boston, Mass., 1991-1992.
Fellowship: Immunology / Allergy, Children's Hospital, Boston, Mass., 1992-1994; Hematology / Oncology, Children's Hospital and Dana Farber Cancer Institute, Boston, Mass., 1992-1995.
Certification: National Board of Medical Examiners, 1991; Board of Registration in Medicine, MA, 1992; American Board of Pediatrics, 1995, 2001; Ohio State Medical Board, 1997; American Board of Allergy and Immunology, 1997; American Board of Pediatrics recertification, 2000.
Position History
Academic Appointments
- 1990-1991 Clinical Fellow in Pediatrics, Harvard Medical School
- 1992-1995 Research Fellow in Pediatrics, Harvard Medical School
- 1995-1996 Instructor of Pediatrics, Harvard Medical School
- 1996-1999 Assistant Professor of Pediatrics, University of Cincinnati College of Medicine
- 1996- Member, Graduate Program Molecular and Developmental Biology, University of Cincinnati College of Medicine
- 1998- Member, Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine
- 1998- Member, Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine
- 1999-2000 Associate Professor of Pediatrics, University of Cincinnati College of Medicine
- 2000-2002 Associate Professor of Pediatrics (tenured), University of Cincinnati College of Medicine
- 2001- Endowed Chair, Allergy and Immunology, Cincinnati Children's Hospital Research Foundation
- 2002- Professor of Pediatrics (tenured), University of Cincinnati College of Medicine
- 2002- Affiliate Faculty, Center for Epidemiology and Biostatistics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center
- 2004- Member, Graduate Program of Immunobiology, University of Cincinnati College of Medicine
Clinical Appointments
- 1990-1991 Intern in Pediatrics, Children's Hospital, Boston, Ma.
- 1991-1992 Resident in Pediatrics, Children's Hospital, Boston, Ma.
- 1992-1994 Immunology/Allergy Fellow, Children's Hospital, Boston,
- 1992-1995 Hematology/Oncology Fellow, Children's Hospital and Dana Farber Cancer Institute, Boston, Ma.
- 1995-1996 Senior Staff Physician, Children's Hospital, Boston, Ma.
- 1996- Staff Physician, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
- 1999-2001 Section Chief, Section of Allergy and Clinical Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
- 2001- Director, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Awards and Honors
- Eastman Kodak Science and Engineering Regional Award, 1976
- National Honor Society, George W. Hewlett High School, 1979
- Phi beta kappa, Brandeis University, 1982
- Melvin N. Snyder Chemistry Award, Brandeis University, 1983
- Summa cum laude with highest honors in biochemistry and chemistry, Brandeis University, 1983
- Medical Scientist Training Program Award, Harvard Medical School, 1985
- Physician Scientist Training Program Award, Harvard Medical School, 1985
- Young Investigator Award, American Academy of Allergy and Immunology, 1988
- Scholar in Allergy Award, American Academy of Allergy and Immunology, 1993
- Pharmacia Allergy Research Foundation Annual Award, 1998
- Governor's Recognition Award, State of Ohio, 2002
- Best Doctors in America Award, 2003
- Awarded "2004 Best Doctors"
- Burton Zweimann Lectureship, American Academy of Allergy, Asthma, and Immunology, 2004
- Awarded "2005 Best Doctors"
- Best Doctors in America, 2008
Research
Eosinophils, chemokines
Publications, Most Recent
View Marc Rothenberg's publications at Cincinnati Children's as listed by PubMed.
Pope SM, Fulkerson PC, Nikolaidis N, Blanchard C, Zimmermann N, Molkentin JD, Rothenberg ME. Identification of a cooperative mechanism involving IL-13 and eotaxin-2 in experimental allergic lung inflammation, J Biol Chem, 2005; 280:13952-61.
Fulkerson PC, Zhu H, Zimmermann N, Rothenberg ME. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism, Blood, 2005;106:436-43.
Akei HS, Mishra A, Blanchard C, Rothenberg ME. Epicutaneous antigen exposure primes for eosinophilic esophagitis, Gastroenterology, 2005; 129:985-994.
Blanchard C, Mishra A, Saito-Akei H, Monk P, Anderson I, Rothenberg ME. Inhibition of human interleukin-13-induced respiratory and esophageal inflammation by anti-human-interleukin-13 antibody (CAT-354), Clin Exper Allergy, 2005; 35:1096-103.
Pope SM, Zimmermann N, Stringer KF, Karow ML, Rothenberg ME. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia, J. Immunol, 2005; 175:5341-5350.
Blanchard C, Wang N. Mishra A, Fulkerson PC, Jameson SC, Kirby C, Konikoff MR, Collins MH, Cohen MB, Stringer KF, Akers R, Hogan SP, Assa'ad AH, Putnam PE, Aronow BJ, Rothenberg ME. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis, J Clin Invest, 2006; 116:536-547.
Yamada Y, Rothenberg ME, Lee AW, Akei HS, Brandt EB, Williams DA, Cancelas JA. The FIP1L1-PDGFR fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease, Blood, 2006; 107:4071-9.
Saito Akei H, Brant EB, Mishra A, Strait RT, Finkelman FD, Warrier MR, Hershey GKH, Blanchard C, Rothenberg ME. Epicutaneous aeroallergen exposure induces systemic Th2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol, 2006; 118-62-9.
Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule (RELM)- regulates innate colonic function: barrier integry and inflammation susceptibility, J Allergy Clin Immunol, 2006; 118:257-68.
DeBrosse CW, Case JW, Putnam PE, Collins ME, Rothenberg ME. Quantity and distribution of eosinophils in the gastrointestinal tract of children, Pediatr Dev Pathol, 2006; 9:210-218.
Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer K, Finkelman FD, MacLeod CL, Ellies L, Zimmermann N. The cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung, Proc Natl Acad Sci USA, 2006; 103:14895-14900.
Konikoff MR, Noel RJ, Blanchard C, Kirby C, Jameson SC, Buckmeier B, Akers R, Cohen MB, Collins MH, Assa'ad AH, Aceves SS, Putnam PE, Rothenberg ME. A randomized double-blind placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis, Gastroenterology, 2006;131:1381-1391. Epub 2006 Aug 16.
Konikoff MR, Blanchard C, Kirby C, Buckmeier B, Cohen MB, Heubi JE, Putnam PE, Rothenberg ME. Potential biomarkers of eosinophilic esophagitis, Clin Gastroenterol Hepatol, 2006; 4:1328-1336. Epub 2006 Oct 21.
Fulkerson PC, Fischetti CA, McBride ML, Hassman LM, Hogan SP, Rothenberg ME. A central regulatory role for eosinophils and the eotaxin-CCR3 axis in chronic experimental allergic airway inflammation, Proc Natl Acad Sci USA, 2006; 103:16418-23. Epub 2006 Oct 23.
Fulkerson PC, Fischetti CA, Rothenberg ME. Eosinophils and CCR3 regulate IL-13-transgene-induced pulmonary remodeling, Am J Pathol, 2006; 169:2117-2126.
Stein ML, Collins MH, Villanueva JM, Kushner JP, Putnam PE, Buckmeier, BK, Filipovich AH, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for eosinophilic esophagitis, J Allergy Clin Immunol, 2006; 118:1312-1319.
Professional Organization Memberships
- Massachusetts Medical Society, 1983-1996
- Physicians for Social Responsibility, 1983-1988
- American Association for the Advancement of Science, 1987-present
- American Academy of Pediatrics, 1990-present
- American Academy of Allergy, Asthma and Immunology, 1993-present
- American Association of Immunologists, 1998-present
- Pharmacia Allergy Research Foundation, 1998-present
- Society for Mucosal Immunology, 1998-present
- Society for Pediatric Research, 1998-present
- American Society of Clinical Investigation, 2000-present
- American Pediatric Society, 2000-present
Books
Rothenberg ME, editor of Chemokines in Allergic Diseases, New York: Marcel Dekker, 2000.
Recent Book Chapters
Rothenberg ME. Eotaxin. In: Thomas E. Creighton, ed. The Encyclopedia of Molecular Medicine, John Wiley & Sons, Inc., New York, 2002; pp 1181-1185.
Zimmermann N, Rothenberg ME. Therapeutic Targeting of Chemokines and Chemokine Receptors. In: Agosti J, Sheffer AL, eds. Biotherapeutic Approaches to Asthma. New York, Marcel Dekker, Inc; 2002. pp. 167-210.
Zimmermann N, Rothenberg ME. Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation. In: Eissa NT, Huston DP, Lenfant C, eds. Lung Biology in Health and Disease: Therapeutic Targets of Airway Inflammation. New York: Marcel Dekker, Inc., 2003 pp 421-463.
Guajardo JR, Rothenberg ME. Eosinophil-Associated Gastrointestinal Disorders: Clinical Features and Pathogenesis. In: Metcalfe D, Sampson H, Simon RA (eds). Food Allergy: Adverse Reactions to Foods and Food Additives, (3rd Edition) Malden, Massachusetts: Blackwell Publishing, Inc., 2003, pp 217-226.
Rothenberg ME. Inflammatory Effector Cells / Cell Migration. In: Leung DYM, Geha R, Sampson H, Szefler A (eds): Pediatric Allergy: Principles and Practice St. Louis: Mosby, 2003, pp 51-68.
Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunology, 2006; 24:147-74.
Fulkerson PC, Rothenberg ME. Chemokines CXC: CXCL9 (mig). In: Laurent GJ, Shapiro SD (eds): Encyclopedia of Respiratory Medicine, London: Elsevier Science, 2006, pp 398-401.
Rothenberg ME. Eosinophilic Syndromes. In: Goldman L, Ausiello D (eds): Cecil Textbook of Medicine, (23rd Edition) Philadelphia: WB Saunders, in press.
Rothenberg ME, Furuta GT. Eosinophilic Esophagitis. In: Yamada T (ed), Alpers DH, Kalloo A, Kaplowitz N. Owyang C, Powell D (associate editors): Textbook of Gastroenterology (5th Edition), in press.
Zuo Li, Rothenberg ME. Eosinophil Associated Gastrointestinal Disorders (EGID). In: Rich RR, Shearer WT, Fleisher TA, Schroeder H, Weyand C, Frew AJ (eds): Clinical Immunology (3rd Edition), Edinburgh, UK: Martin Mellor Publishing Services, Ltd, in press.
Rothenberg ME. Eosinophilic Gastroenteropathies. In: Adkinson NF, Busse WW, Bochner BS, Holgate ST, Simons FER, Lemanske RF (eds): Middleton's Allergy (7th Edition), London: Elsevier, in press.
Rothenberg ME. Biology of Eosinophils. In: Adkinson NF, Busse WW, Bochner BS, Holgate ST, Simons FER, Lemanske RF (eds): Middleton's Allergy (7th Edition), London: Elsevier, in press.
Special Interests
Hypereosinophilia; asthma; allergy; food allergy
Scientific Reviews
Editorial Boards
- 1999-2003 Journal of Allergy and Clinical Immunology
- 2001-2003 Journal of Immunology
- 2004- Journal of Allergy and Clinical Immunology, Guest Editor
- 2004- Journal of Clinical Investigation, Board of Consulting Editors
- 2004- Current Immunology Reviews, Editorial Board
Scientific Expert Panel
- 2001 Consultant, Environmental Protection Agency, Special Expert Panel on Regulation of Transgenic Food; Washington D.C.
- 2002 Consultant, NIAID Expert Panel on Atopic Dermatitis and Vaccinia Immunization; Bethesda, MD
- 2003 Food Allergy Expert Panel, NIH-NIAID, Bethesda, MD
- 2004 Eosinophilia Myalgia Syndrome Worshop, NIH-NIAID, Bethesda, MD
- 2006 NIH Expert Panel on Food Allergy, NIH-NIAID, Bethesda, MD
Scientific and Medical Boards
- 2000-2003 Gift of Life Foundation (a bone marrow donor registry)
- 2001- American Partnership for Eosinophilic Disorders
- 2002- International Advisory Board for "Eosinophil Rising
- 2003 3rd Biennial International Eosinophil Symposium
- 2003- Executive Committee, International Eosinophil Society
Recent Invited Lectures and Symposia
2001
- VIII Symposium on Immunological, Chemical and Clinical Problems on Food Allergy, Venice, Italy, Invited Speaker
- Meakins-Christie Workshop on Pathogenesis and Treatment of Asthma and COPD: Current and Future Aspects, Montreal, Canada, Invited Speaker
- The Toxicology Forum 2001 Annual Winter Meeting, Washington, DC, Invited Speaker
- ILSI Health and Environmental Sciences Institute, Protein Allergenicity Subcommittee, Washington, DC, Invited Participant
- Immunobiology Seminar Series, Mt. Sinai Medical Center, New York, NY, Invited Speaker
- Immunology Seminar Series, Beirne B. Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, Virginia, Invited Speaker
- American Gastroenterological Association, Digestive Disease Week 2001, Atlanta, Georgia, Invited Speaker
- International Eosinophil Society, Eosinophil 2001 International Symposium, Banff, Alberta, Canada, Invited Speaker
- Schneider's Children's Hospital, Israel, Invited Speaker
- Aspen Allergy Conference, Given Institute of Pathobiology, Aspen, Colorado, Invited Speaker
- John Curtin School of Medical Research, Australian National University, Canberra, Australia, Invited Speaker
2002
- 5th Annual Meakins Christie Workshop on Pathogenesis and Treatment of Asthma, Montreal, Canada, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Postgraduate Plenary Session, Invited Speaker
- 18th Annual Dr. Dorothy Wiselberg Seminar, The Respiratory Division and the Meakins-Christie Laboratories, Montreal, Canada, Invited Speaker
- Southeastern Allergy, Asthma and Immunology Society, 57th Annual Meeting, Sea Island, Georgia, Invited Speaker
- St. Louis University, Cardinal Glennon Children's Hospital, Pediatric Grand Rounds, St. Louis, Missouri, Invited Speaker
- NIH, Laboratory of Allergic Disease, Invited Speaker
- Johns Hopkins Medical Center, Invited Speaker
- Cleveland Clinic, Invited Speaker
2003
- Meakins Christie Workshop on Asthma and COPD, Montreal, Quebec Canada, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Workshop, Denver, Colorado, Invited Speaker
- The Emery Educational Society of Cincinnati Children's Hospital Medical Center, Invited Speaker
- University of Southern California ENT Conference, Invited Speaker
- University of California at Los Angeles, Department of Allergy and Immunology Conference, Invited Speaker
- Federation of Clinical Immunology Societies (FOCIS) annual meeting, Paris, France, Invited Speaker
- University of Alabama Birmingham, Invited Speaker
- McMaster University, Distinguished Speaker Series, Hamilton, Ontario, Canada, Invited Speaker
- Arginine Symposium, Southampton Princess Hotel, Bermuda, Invited Speaker
- Hypereosinophil Syndromes Workshop, Snowmass Village, Colorado, Invited Speaker
- The 3rd International Eosinophil Symposium – Eosinophil Rising, Snowmass, Colorado, Invited Speaker and Moderator
- World Allergy Organization (WAO) Congress – XVIII ICACI, Vancouver, Canada, Invited Plenary Speaker
2004
- Building a Better World Through Medicine II, Jerusalem, Israel
- University of Illinois and Rush University, Division of Allergy and Immunology, Chicago, Illinois, Invited Speaker
- Northwestern University, Division of Allergy, Chicago, Illinois, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Postgraduate Symposium, The Burton Zweiman Lectureship, San Francisco, California, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Workshop, San Francisco, California, Invited Plenary Speaker
- American Gastroenterological Association, Digestive Disease Week 2004, New Orleans, Louisiana, Invited Speaker
- Allergy Fellows Symposium, Orlando, Florida, Invited Speaker
- Israel Allergy Academy, Invited Speaker
- Department of Pediatrics, Asaf Medical Center, Ramla, Israel, Invited Speaker
- Tel Aviv Sourasky Medical Center, Israel, Department of Gastroenterology, Invited Speaker
- Kfar Saba Medical Center, Department of Medicine, Israel, Grand Rounds, Invited Speaker
- XXIII Annual Congress of the European Academy of Allergology and Clinical Immunology, Amsterdam, Invited Speaker
- Department of Medicine, Asaf Medical Center, Ramla, Israel, Invited Speaker
- Department of Gastroenterology, Tel Aviv University, Israel, Invited speaker
- Department of Pediatrics, Pediatric Grand Rounds, Schneider's Children's Hospital Medical Center, Israel, Invited Speaker
2005
- Controversies and New Findings in Allergies CYNA Meeting, Madrid, Spain, Invited Speaker
- Biennial Congress of the International Eosinophil Society, Bern, Switzerland, Invited Speaker
- Federation of Clinical Immunology Societies (FOCIS) annual meeting, Boston, Invited Speaker
- Idea Congress s.r.l Rome, DAM 8 2005, Rome, Italy, Invited Speaker
- Aspen Allergy Conference, Aspen, Colorado, Invited Speaker
- Japanese Society for Immunology (JSI) Presidential Symposium, Yokahama, Japan, Invited Speaker
- American College of Allergy, Asthma and Immunology, Annual Meeting, Invited Plenary Speaker
2006
- American Academy of Allergy, Asthma and Immunology, Annual Meeting, Miami, Florida, Invited Speaker
- Keystone Symposium on Allergy, Allergic Inflammation and Asthma, Breckenridge, Colorado, Invited Speaker
- Digestive Disease Week / Eosinophilic Gastrointestinal Disorders meeting, Los Angeles, California, Invited Speaker
- Division of Allergy and Immunology, University of Michigan, Ann Arbor, Michigan, Invited Speaker
- Eosinophils in GI Health and Disease, Children's Hospital of Philadelphia, Invited Speaker
- American Partnership for Eosinophilic Disorders (APFED) Annual Meeting, Philadelphia, Pennsylvania, Invited Speaker
- Blue Grass Allergy Society, Lexington, Kentucky, Invited Speaker
- Israeli Association of Allergy and Clinical Immunology (Israeli Medical Association), Invited Speaker
- North American Society Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Postgraduate Course, Orlando, Florida, Invited Speaker
- First International Gastrointestinal Eosinophilic Research Symposium (FIGERS), Orlando, Florida, Invited Speaker
- American College of Allergy, Asthma and Immunology, Annual Scientific Meeting, Philadelphia, Pennsylvania, Invited Speaker
- American Society of Hematology annual meeting, Orlando, Florida, Invited Speaker
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
