Anjaparavanda P. Naren, PhD

Thomas Boat Chair in Cystic Fibrosis Research, Division of Pulmonary Medicine, Research
Director, Cystic Fibrosis Research Center, Division of Pulmonary Medicine, Research
Professor, UC Department of Pediatrics

brenda.mcmillan@cchmc.org

About

Biography

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel located primarily on the apical surface of epithelial cells that line various organs, including the airways and the gut. CFTR dysfunction is detrimental and may result in life-threatening medical disorders. Dr. Naren's laboratory studies two such disorders; (1) Cystic fibrosis, a lethal genetic disease that affects mostly the Caucasian population (>30,000 in USA), in which the CFTR chloride channel is HYPO-functional and (2) Secretory diarrhea, a disease affecting millions of children worldwide, in which HYPER-function of the CFTR chloride channel can occur due to infectious toxins, such as cholera toxin and E. coli enterotoxin. His lab is interested in identifying interactions between CFTR and its binding partners and defining how spatiotemporal regulation of CFTR-containing macromolecular complexes in the apical compartment of polarized epithelial cells lining the secretory epithelia regulates overall fluid secretion. Our studies will identify new drug targets for cystic fibrosis, secretory diarrhea, and other diseases resulting from CFTR dysfunction and provide insights into the etiology of diseases associated with CFTR-interacting molecules.

Services and Specialties

Cystic Fibrosis Center

Interests

Cystic fibrosis; secretory diarrhea.

Research Areas

Pulmonary Medicine

Publications

ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity. Ranjit, S; Wang, Y; Zhu, J; Cheepala, SB; Schuetz, EG; Cho, WJ; Xu, B; Robinson, CG; Wu, G; Naren, AP; et al. Drug Resistance Updates. 2024; 72:101017.

A personalized medicine approach to optimize care for a pediatric cystic fibrosis patient with atypical clinical symptoms. Lee, J; Husami, A; Arora, K; Zhang, W; Kadri, F; Yarlagadda, S; Moon, C; Mun, KS; Zhang, K; Huang, Y; et al. Pediatric Pulmonology. 2024; 59:229-232.

Guided construction of single cell reference for human and mouse lung. Guo, M; Morley, MP; Jiang, C; Wu, Y; Li, G; Du, Y; Zhao, S; Wagner, A; Cakar, AC; Kouril, M; et al. Nature Communications. 2023; 14:4566.

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Mastracci, TL; Apte, M; Amundadottir, LT; Alvarsson, A; Artandi, S; Bellin, MD; Bernal-Mizrachi, E; Caicedo, A; Campbell-Thompson, M; Cruz-Monserrate, Z; et al. Diabetes. 2023; 72:433-448.

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Mastracci, TL; Apte, M; Amundadottir, LT; Alvarsson, A; Artandi, S; Bellin, MD; Bernal-Mizrachi, E; Caicedo, A; Campbell-Thompson, M; Cruz-Monserrate, Z; et al. Pancreas. 2022; 51:1061-1073.

Is There a Benefit From Islet Autotransplantation in Patients With Type 1 Diabetes Mellitus Undergoing Total Pancreatectomy?. Mun, KS; Nathan, JD; Lin, TK; Elder, DA; Jegga, AG; Naren, AP; Abu-El-Haija, M. Pancreas. 2022; 51:399-403.

Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability. Hou, Y; Sun, X; Gheinani, PT; Guan, X; Sharma, S; Zhou, Y; Jin, C; Yang, Z; Naren, AP; Yin, J; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2022; 14:375-403.

5.06 Pharmacology of Secretory Diarrhea. Arora, K; Naren, AP. Comprehensive Pharmacology. : Elsevier; Elsevier; 2022.

Crystal structure of RahU, an aegerolysin protein from the human pathogen Pseudomonas aeruginosa, and its interaction with membrane ceramide phosphorylethanolamine. Kocar, E; Lenarcic, T; Hodnik, V; Panevska, A; Huang, Y; Bajc, G; Kostanjšek, R; Naren, AP; Macek, P; Anderluh, G; et al. Scientific Reports. 2021; 11:6572.

Evaluation of Risk Scores to Predict Pediatric Severe Asthma Exacerbations. Niu, C; Xu, Y; Schuler, CL; Gu, L; Arora, K; Huang, Y; Naren, AP; Durrani, SR; Hossain, MM; Guilbert, TW. Journal of Allergy and Clinical Immunology: In Practice. 2021; 9:4393-4401.e8.

From the Blog

Tools for Science

Pancreas-On-A-Chip May Advance Cystic Fibrosis Research

Anjaparavanda P. "AP" Naren, PhD8/12/2019