Jonathan W. Byrnes, MD

Director, Cardiac ECMO

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-1801


Jonathan Byrnes, MD, is an assistant professor of pediatrics with the University of Cincinnati College of Medicine and an attending cardiac intensivist in Cincinnati Children’s Hospital Medical Center’s Cardiac Intensive Care Unit. He joined the faculty in July 2013. 

A native of Mississippi, Dr. Byrnes graduated with honors from University of Mississippi and earned his medical degree from University of Mississippi Medical Center in 2005. He completed his pediatric residency at Blair Batson Children's Hospital in Jackson, MS and a combined fellowship in cardiology and critical care medicine at Arkansas Children's Hospital. Dr. Byrnes’s clinical interests are providing superb, cost-effective care and delivering cohesive management amongst all specialties in the cardiac intensive care unit.

Dr. Byrnes is active in clinical and translational research involving extracorporeal life support that would benefit critically ill children. This research is primarily focused on the biocompatibility of the patient / device interface and the associated interaction of the coagulation and inflammatory pathways. The aim of these endeavors is to ultimately decrease the incidence of end organ dysfunction and stroke associated with these therapies.

MD: University of Mississippi Medical Center, Jackson, MS, 2005.

Residency: Pediatrics, University of Mississippi Medical Center, Jackson, MS, 2008.

Fellowships: Combined Pediatric Cardiology and Pediatric Critical Care Medicine, Arkansas Children's Hospital, University of Arkansas Medical Sciences, Little Rock, AR, 2013.

Certification: American Board of Pediatrics, 2008.

View PubMed Publications

Prodhan P, Imamura M, Garcia X, Byrnes J, Bhutta A, Dyamenahalli U. Abdominal Compartment Syndrome in Newborns and Children supported on Extracorporeal Membrane Oxygenation. ASAIO J.  2012;58(2): 143-147.

Byrnes J, Williams B, Prodhan P, Erdem E, Williamson R, Gautam N, James C, Jaquiss R, Imamura M, Bhutta A. Successful intra-arterial thrombolytic therapy for a right middle cerebral artery stroke in a 2-year old supported by a ventricular assist device. Transpl Int. 2012;25(3): e31-33.

Byrnes J, W McKamie, C Swearingen, Gossett J, Prodhan P, Bhutta A, Jaquiss R, Imamura M, Fiser R. Hemolysis during Cardiac Extracorporeal Membrane Oxygenation: A Case-Control Comparison of a Roller Pump and a Centrifugal Pump in a Pediatric Population. ASAIO J. 2011 Sep-Oct;57(5):456-61.

Byrnes J, Prodhan P, Imamura M, Frazier E. Accidental Azygos Vein Extracorporeal Membrane Oxygenation Cannulation in a Neonate with Premature Closure of the Ductus Arteriosus. ASAIO J. 2011 Jul-Aug; 57(4): 344-5.