A photo of John Clancy.

Member, Division of Pulmonary Medicine

Professor, UC Department of Pediatrics

513-636-6771

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My Biography & Research

Biography

John P. Clancy, MD, has served in several leadership roles at Univeristy of Alabama, Cincinnati Children's and within the international cystic fibrosis (CF) community. Some of his leadership roles include membership on the CFF Clinical Research Committee (2003 to present), the CFF-TDN Steering Committee (2002 to 2007), the CFF-TDN Translational Research Center Committee (2008 to present), DSMB membership for the Rare Lung Disease Consortium within the NIH Rare Disease Research Network (2005 to 2009, Chairman from 2010 to present); organizing committee membership for the North American CF Conference (2003 to present) and the European CF Society (2010), co-chair of the CFFT Biomarkers Consortium (2010 to present), member of the Promotion and Tenure Committee for the UAB Department of Pediatrics (2003 to 2010) and the UAB SOM (2007 to 2010, including committee chair).

Dr. Clancy has been the primary or co-mentor of more than 20 fellows, graduate students and junior faculty. He has been the initial recipient of two endowed chairs, including the Raymond K. Lyrene Chair in Pediatric Pulmonary Medicine at the University of Alabama (2005), and the Tom Boat Chair in Cystic Fibrosis Clinical and Translational Research at Cincinnati Children's (2011).

Clinical Interests

Cystic fibrosis; airway cellular biology; CFTR regulation

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Pulmonary Medicine, Cystic Fibrosis, Pulmonary Medicine

My Education

MD:  University of Iowa College of Medicine, Iowa City, IA.

Residency:  University of Virginia, Charlottesville, VA.

Fellowship:  University of Alabama at Birmingham, Birmingham, AL.

My Publications

Clinically approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia. Borcherding, DC; Siefert, ME; Lin, S; Brewington, J; Sadek, H; Clancy, JP; Plafker, SM; Ziady, AG. Journal of Clinical Investigation. 2019; 130:3448-3463.

Antisense oligonucleotide eluforsen improves CFTR function in F508del cystic fibrosis. Sermet-Gaudelus, I; Clancy, JP; Nichols, DP; Nick, JA; De Boeck, K; Solomon, GM; Mall, MA; Bolognese, J; Bouisset, F; den Hollander, W; et al. Journal of Cystic Fibrosis. 2019; 18:536-542.

Aerosolized agents for airway clearance in cystic fibrosis. Southern, KW; Clancy, JP; Ranganathan, S. Pediatric Pulmonology. 2019; 54:858-864.

Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis. Liou, TG; Adler, FR; Argel, N; Asfour, F; Brown, PS; Chatfield, BA; Daines, CL; Durham, D; Francis, JA; Glover, B; et al. BMC Medical Research Methodology. 2019; 19.

Direct Lung Sampling Indicates That Established Pathogens Dominate Early Infections in Children with Cystic Fibrosis. Jorth, P; Ehsan, Z; Rezayat, A; Caldwell, E; Pope, C; Brewington, JJ; Goss, CH; Benscoter, D; Clancy, JP; Singh, PK. Cell Reports. 2019; 27:1190-1204.e3.

A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus. Fernandez-Petty, CM; Hughes, GW; Bowers, HL; Watson, JD; Rosen, BH; Townsend, SM; Santos, C; Ridley, CE; Chu, KK; Birket, SE; et al. JCI insight. 2019; 4.

Sweat Chloride Testing. McCarthy, C; Clancy, JP; Brewington, J. Journal of the American Medical Association. 2019; 321:701-702.

CFTR modulator theratyping: Current status, gaps and future directions. Clancy, JP; Cotton, CU; Donaldson, SH; Solomon, GM; VanDevanter, DR; Boyle, MP; Gentzsch, M; Nick, JA; Illek, B; Wallenburg, JC; et al. Journal of Cystic Fibrosis. 2019; 18:22-34.

Improving Detection of Rapid Cystic Fibrosis Disease Progression-Early Translation of a Predictive Algorithm Into a Point-of-Care Tool. Szczesniak, RD; Brokamp, C; Su, W; Mcphail, GL; Pestian, J; Clancy, JP. IEEE Journal of Translational Engineering in Health and Medicine-JTEHM. 2019; 7.

Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. Wu, AC; Kiley, JP; Noel, PJ; Amur, S; Burchard, EG; Clancy, JP; Galanter, J; Inada, M; Jones, TK; Kropski, JA; et al. American Journal of Respiratory and Critical Care Medicine. 2018; 198:1479-1489.