Michael A. Helmrath, MD
- Director, Center for Stem Cell & Organoid Medicine (CuSTOM)
- Director, Surgical Research
- Director, Center for Bariatric Research and Innovation
- Pediatric Surgeon
- Professor, UC Department of Surgery
- michael.helmrath@cchmc.org
- Board Certified
About
Biography
As a pediatric surgeon-scientist, I'm dedicated to helping patients with intestinal diseases and obesity. I always wanted to be a physician — caring for children and conducting research focused on strategies to improve the outcomes of those with intestinal failure.
My clinical interests are bariatric surgery and surgery to correct intestinal failure. My clinical work allows me to translate gastrointestinal conditions into the laboratory, where we are working to develop highly innovative approaches for treating intestinal diseases.
In my research lab, I've established a multidisciplinary team dedicated to translational, clinical, and basic science research focused on intestinal diseases. We are characterizing intestinal stem cells during adaptation and are working to develop intestinal regenerative strategies.
I believe that understanding the biology of intestinal stem cells is key to unraveling the mechanisms involved during the disease process. In my lab, we've developed in vitro culture techniques to maintain and expand individual human intestinal stem cells derived from human tissue samples, pluripotent stem cells, and surgical animal models.
I serve as the Director of Surgical Research, Director of the Center for Bariatric Research and Innovation, and Director of the Center for Stem Cell & Organoid Medicine (CuSTOM). I am board certified in General Surgery and Pediatric Surgery.
BA: Miami University, Oxford, OH, 1987.
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.
MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.
Certification: Board-certified General Surgery; board-certified, Pediatric Surgery.
Interests
Surgery - general and thoracic; intestinal disorders; surgical weight loss
Services and Specialties
Surgery - General and Thoracic, Intestinal Disorders, Surgical Weight Loss
Interests
Intestinal diseases research
Research Areas
General and Thoracic Surgery
Insurance Information
Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.
Publications
RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Nature Communications. 2023; 14:8159.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon. Cell Stem Cell. 2023; 30:1434-1451.e9.
Reducing Unnecessary Oophorectomies for Benign Ovarian Neoplasms in Pediatric Patients. Journal of the American Medical Association. 2023; 330:1247-1254.
Development and Implementation of a Multidisciplinary Clinic Focused on the Care of Adolescents with Youth-Onset Type 2 Diabetes. Journal of Multidisciplinary Healthcare. 2023; 16:2799-2807.
Chronic Mucosal Inflammation in Pediatric Intestinal Failure Patients-A Unique Phenomenon. Journal of Pediatric Gastroenterology and Nutrition. 2023; 77:e29-e35.
84: Inflammatory Bowel Disease-Like Findings in Pediatric Intestinal Failure Patients. Transplantation. 2023; 107:50.
1115-P: Advanced Medical Therapy (AMT) for Youth-Onset Type 2 Diabetes (T2D)—Early Results from the Run-in Phase of ST2OMP. Diabetes. 2023; 72.
1105-P: Development and Implementation of a Multidisciplinary Clinic Focused on Youth-Onset Type 2 Diabetes. Diabetes. 2023; 72.
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice. Nature Biotechnology. 2023; 41:824-831.
Applying patient personalized organoid model system to understand complex GI manifestations in cystic fibrosis disease. Physiology (Bethesda, Md.). 2023; 38:5711443.
From the Blog
Organoids Validated as Tool for Studying Fetal Intestine Development
Michael A. Helmrath, MD5/4/2023
Novel Approach Generates Most Complex Stomach, Esophagus Organoids to Date
Michael A. Helmrath, MD, James M. Wells, PhD ...2/8/2023
Scientists Add Nerves to Intestinal Organoids
Michael A. Helmrath, MD, James M. Wells, PhD6/30/2019
Overcoming Nature’s Complexity to Help Patients with Intestinal Disease
10/20/2014
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026
© 1999-2024 Cincinnati Children's Hospital Medical Center. All rights reserved.
Patient Ratings and Comments
All patient satisfaction ratings and comments are submitted by actual patients and verified by a leading independent patient satisfaction company, NRC Health. Patient identities are withheld to ensure confidentiality and privacy. Only those providers whose satisfaction surveys are administered through Cincinnati Children’s Hospital Medical Center are displayed. Click here to learn more about our survey