Eric S. Kirkendall, MD, MBI, FAAP

Associate Chief Medical Information Officer, Information Services

Attending Hospitalist, Division of Hospital Medicine

Clinical Informaticist, Division of Biomedical Informatics

Academic Affiliations

Associate Professor, UC Department of Pediatrics

UC Department of Biomedical Informatics

Phone 513-636-1945

Fax 513-803-9245



Hospital medicine


Medical/clinical informatics; patient safety; quality improvement; artificial intelligence; novel software development

Dr. Kirkendall works to use health information technology to maximize patient safety and quality in clinical care delivery, data management, and novel application/software development. He is the first Associate Chief Medical Information Officer in Cincinnati Children's history. In that role he oversees the design, implementation, and optimization of the electronic health record and other associated technologies.

Dr. Kirkendall co-leads the Decision Support Analytics Workgroup (DSAW), which investigates the links between the effectiveness of clinical decision support (CDS), patient safety, and user efficiency. His research has demonstrated ties between decreasing alert burden on clinicians, increasing CDS alert salience, and improving patient outcomes.

Many of Dr. Kirkendall’s research projects have also incorporated artificial intelligence techniques (e.g., natural language processing) and other innovative methods to detect adverse events/harm across multiple hospital environments. The results have shown vast improvements in detecting errors related to medication administrations.

Dr. Kirkendall has also worked with the Center for Acute Care Nephrology to develop a catalog of detection and risk-stratifying electronic triggers that have resulted in NTMx-AKI reductions of 25-50% across four novel metrics, preventing over 400 children from developing AKI.

BS: Biology, University of Toledo, Toledo, OH, 1999.

MD: University of Cincinnati, Cincinnati, OH, 2003.

Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006.

MBI: Oregon Health & Science University, Portland, OR, 2012.

Certification: American Board of Pediatrics, 2006; Clinical Informatics, 2014.

View PubMed Publications

Goldstein SL, Mottes T, Simpson K, Barclay C, Muething S, Haslam DB, Kirkendall ES. A sustained quality improvement program reduces nephrotoxic medication-associated acute kidney injury. Kidney Int. 2016 Jul;90(1):212-21.

Lehmann CU, Council on Clinical Information Technology, Weinberg ST, Alexander GM, Beyer EL, Del Beccaro MA, Francis AB, Handler EG, Johnson TD, Kirkendall ES, Lighter DE, Morgan SJ, Raskas MD, Tham E, Webber EC. Pediatric Aspects of Inpatient health Information Technology Systems. Pediatrics. 2015 Mar.

Goldstein SL, Kirkendall E, Nguyen H, Schaffzin JK, Bucuvalas J, Bracke T, Seid M, Ashby M, Foertmeyer N, Brunner L, Lesko A, Barclay C, Lannon C, Muething S. Electronic Health Record Identification of Nephrotoxin Exposure and Associated Acute Kidney Injury. Pediatrics. 2013 Sep;132(3):e756-67.

Kirkendall ES, Kloppenborg E, Papp J, White D, Frese C, Hacker D, Schoettker PJ, Muething S, Kotagal U. Measuring Adverse Events and Levels of Harm in Pediatric Inpatients with the Global Trigger Tool. Pediatrics. 2012 Nov;130(5):e1206-14.

Narus SP, Srivastava R, Gouripeddi R, Livne OE, Mo P, Bickel JP, de Regt D, Hales JW, Kirkendall E, Stepanek RL, Toth J, Keren R. Federating clinical data from six pediatric hospitals: process and initial results from the PHIS+ Consortium. AMIA Annu Symp Proc. 2011;2011:994-1003.

Improving Intensive Care Medication Safety through EHR-based Algorithms. Principal Investigator. National Library of Medicine. 2015-2019.

NINJA2: Reduction of Nephrotoxic Medication-associated Acute Kidney Injury in Children. Co-investigator. Agency for Healthcare Research and Quality. 2015-2018.

Pursuing Perfection in Pediatric Therapeutics. Clinical Scientist – Informatics Expert. Agency for Healthcare Research and Quality. 2011-2016.