Kakajan Komurov , PhD

Member, Division of Experimental Hematology & Cancer Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-5122

Email kakajan.komurov@cchmc.org

Computational and experimental approaches to characterize targetable cancer vulnerabilities; oncogene-induced stress pathways in cancer therapy; the study of mechanisms, implications and therapeutic vulnerabilities imposed by the severe epigenetic defects in a subset of cancers

Visit the Komurov Lab.

Dr. Komurov's lab focuses on the systems biology of cancer. We develop and employ computational data mining tools to interrogate clinically exploitable cancer mechanisms from cancer genomics data, and use experimental approaches in vitro and in animal models for their molecular characterization. Specifically, we are studying the core aberrations in the genomic, RNA and protein homeostasis networks in cancers, their role in cancer pathogenicity and therapy response, and the synthetic vulnerabilities imposed by these defects on the tumor cell. In addition, we are developing computational methods and software to enable intuitive and effective functional mining of genomic data.
PhD: The University of Texas Southwestern Medical Center, Dallas, TX.

Modeling and targeting the hexosamine pathway in drug resistance. Principal Investigator. Susan G. Komen for the Cure. Aug 2013-Jul 2016. CCR13263034.

Exploiting proteotoxic stress in therapy-refractory HER2+ breast cancers. Principal Investigator. National Cancer Institute. Apr 2015-Mar 2020. 1R01CA193549-01.

Global Transcript Shortening in cancers. Principal Investigator. Cincinnati Children's Hospital Medical Center RIP award. Sep 2015-Aug 2016.