Keith Marsolo, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-0333

Fax 513-636-2056


Dr. Marsolo’s research interests include methods to characterize the quality and suitability of electronic health record (EHR) data; approaches to collect and extract research data from the EHR at scale; the design and instantiation of common data models to facilitate distributed research queries; and the development of informatics architectures and standards that can support multi-center learning health systems.

Dr. Marsolo serves as faculty advisor for BMI Data Services, which provides services in these areas. He is currently building on several grants from the Agency for Healthcare Research and Quality to design and implement an EHR-linked registry architecture for ImproveCareNow, a 94-center quality improvement and research network that focuses on improving the care and outcomes of children with inflammatory bowel disease (IBD). He and his team are extending the platform to support a pragmatic clinical trial that is being funded by the Patient-Centered Outcomes Research Institute (PCORI). This pragmatic trial will serve as an initial use case for a recently funded grant from the Office of National Coordinator for Health Information Technology (ONC) to pilot the use of interoperability standards and embed case report forms in the EHR, decreasing the amount of time spend on double data entry during research study visits.

Other recent highlights include work on Phase I and II of PCORI’s National Patient-Centered Clinical Research Network (PCORnet), including a pediatric-focused Clinical Data Research Network (CDRN), and a Patient-Powered Research Network (PPRN) with ImproveCareNow. In addition, Dr. Marsolo is a co-investigator within the Distributed Research Network Operations Center of the PCORnet Coordinating Center, served as one of the co-chairs of the PCORnet’s Data Standards, Security and Network Infrastructure (DSSNI) Task Force during Phase I of the project, and is a member of the Data Committee as part of Phase II.

BS: Computer Science and Engineering, The Ohio State University, Columbus, OH, 2002.

MS: Biomedical Engineering, The Ohio State University, Columbus, OH, 2005; Computer and Information Science, The Ohio State University, Columbus, OH, 2006.

PhD: Computer and Information Science, The Ohio State University, Columbus, OH, 2007.

View PubMed Publications

Marsolo K, Margolis PA, Forrest CB, Colletti RB, Hutton JJ. A Digital Architecture for a Network-Based Learning Health System – Integrating Chronic Care Management, Quality Improvement, and Research. eGEMs (Generating Evidence & Methods to improve patient outcomes). 2015 Aug 17;3(1):1168.

Forrest C, Crandall W, Bailey C, Zhang P, Joffe M, Colletti R, Adler J, Baron H, Berman J, DelRosario F, Grossman A, Hoffenberg E, Israel E, Kim S, Lightdale JR, Margolis P, Marsolo K, Mehta D, Milov D, Patel A, Tung J, Kappelman M. Effectiveness of Anti-TNFα for Crohn’s Disease: Research in a Pediatric Learning Health System. Pediatrics. 2014 Jul;134(1):37-44.

Marsolo K. Informatics & operations – let’s get integrated. J Am Med Inform Assoc. 2013 Jan 1;20(1):122-4.

Marsolo K. In Search of a Data-in-Once, Electronic Health Record-Linked, Multicenter Registry— How Far We Have Come and How Far We Still Have to Go. EGEMS (Wash DC). 2013 Jan 17;1(1):1003.

Marsolo K, Corsmo J, Barnes MG, Pollick C, Chalfin J, Nix J, Smith C, Ganta R. Challenges in creating an opt-in biobank with a registrar-based consent process and a commercial EHR. J Am Med Inform Assoc. 2012 Nov-Dec;19(6):1115-8.