John Shannon, PhD

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-2938

Fax 513-636-7868

Email john.shannon@cchmc.org

Clinical

Lung morphogenesis and differentiation; isolation and characterization of genes differentially expressed in the developing lung; maintenance of alveolar lung cell differentiation; pulmonary vascular development; congenital diaphragmatic hernia

Research

Elucidation of the molecular mechanisms that regulate morphogenesis; differentiation of the lung epithelium

AB: Biology, University of California, Santa Cruz, CA, 1972.

PhD: University of California, Berkeley, CA, 1979.

View PubMed Publications

Rankin SA, Han L, McCracken KW, Kenny AP, Anglin CT, Grigg EA, Crawford CM, Wells JW, Shannon JM, Zorn AM. A retinoic acid-hedgehog cascade coordinates mesoderm inducing signals and endoderm competence during lung specification. Cell Reports. 2016;16:66-78.

Kurmann A, Serra M, Hawkins F, Rankin SA, Mori M, Astapov I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells. Cell Stem Cell. 2015;17:527-542.

Lin S, Moon C, Naren AP, Shannon JM. LPCAT1 Specifically interacts with StarD10 to facilitate surfactant phospholipid trafficking in alveolar type II cells. J Biol Chem. 2015;290:18559-18574.

Havrilak JA, Shannon JM. Branching of lung epithelium in vitro occurs in the absence of endothelial cells. Dev Dyn. 2015;244:553-563.

Bridges JP, Lin S, Ikegami M, Shannon JM. Condtional hypoxia inducible factor alpha induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012;362:24-41. 

Bridges JP, Ikegami M, Brilli LL, Chen X, Mason RJ, Shannon JM. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. J Clin Invest. 2010 May 3;120(5):1736-48.

Metzger DE, Stahlman MT, Shannon JM. Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation. Dev Biol. 2008 Aug 1;320(1):149-60.

Lin S, Ikegami M, Xu Y, Bosserhoff AK, Malkinson AM, Shannon JM. Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol. 2008 Apr 15;316(2):441-55.

Metzger DE, Xu Y, Shannon JM. Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev Dyn. 2007 May;236(5):1175-92.

Chen X, Hyatt BA, Mucenski ML, Mason RJ, Shannon JM. Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11724-9.