Harinder Singh, PhD, will join Cincinnati Children’s as Director of Immunobiology this fall.

Singh is an expert on regulatory molecules that enable a self-renewing pluripotent hematopoietic stem cell to generate various cells of the immune system. His laboratory focuses on genetic and molecular analyses of transcription factors that regulate the development and differentiation of immune cells. His group has identified key regulatory proteins that control the generation of both innate and adaptive cells of the immune system.

Before coming to Cincinnati Children’s, Singh worked since 2009 in the Department of Discovery Immunology at Genentech in San Francisco, where his roles included overseeing drug discovery and development projects.   Before that, he worked for six years at the University of Chicago as Louis Block Professor of Molecular Genetics & Cell Biology, an investigator with the Howard Hughes Medical Institute, and Chair of the Committee on Immunology.

Singh says he accepted the post at Cincinnati Children’s in large part because he was interested in returning to the front end of the drug development pipeline.

“Deep down, I’m really a basic scientist. That’s what motivates me,” Singh says. “I’ve seen and experienced the whole process and I believe that the fundamental research needed to generate drug development is best done in the academic sphere.”

One of his goals at Cincinnati Children’s is to build a Center for Systems Immunology, which would seek to develop new approaches to therapy by studying how the immune system is influenced by the interactions of large networks of genes.

Singh earned his PhD in Biochemistry and Molecular Biology in 1984 from Northwestern University and completed a post-doctoral fellowship in cancer research at the Massachusetts Institute of Technology in 1988.

He has authored more than 50 research papers, articles and book chapters and served as editor of Molecular and Cellular Biology from 1997-2007. He has presented at scientific meetings throughout the United States, Europe, and Asia and was a member of the Board of Scientific Counselors for the National Cancer Institute. Singh also currently serves as an advisor to the California Institute for Regenerative Medicine.