Fig A:  In traditional Mendelian genetics (top image), pregnancies among female offspring are equally susceptible to fetal wastage or other complications. This stems from disruptions in fetal tolerance regardless of paternal major histocompatibility complex haplotype specificity.  Comparatively, persistent postnatal maintenance of tolerogenic microchimeric maternal cells in female offspring promotes cross-generational reproductive fitness (bottom image). It does this by selectively protecting against fetal wastage during next-generation pregnancies sired by males with shared overlapping non-inherited maternal antigens specificity.

Infectious Diseases

Featured Research

Microchimeric Maternal Cells Promote Reproductive Fitness Across Generations

The long-standing scientific mystery of how the developing fetus avoids rejection by their mother’s immune cells remains unresolved. However, new clues are emerging.

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