Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinjé J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PM. Serological Correlates of Protection against a GII.4 Norovirus. Clin Vaccine Immunol. 2015 Aug;22(8):923-9.
Currently the correlate of protection against Norovirus is unclear. Having a good correlate will enhance our ability to determine the predicted efficacy of a vaccine candidate. This study furthers our understanding of protection against norovirus and may lead to improved ability to evaluate candidate vaccines.
Bernstein DI, Munoz FM, Callahan ST, Rupp R, Wootton SH, Edwards KM, Turley CB, Stanberry LR, Patel SM, McNeal MM, Pichon S, Amegashie C, Bellamy AR. Safety and efficacy of a cytomegalovirus glycoprotein B (gB) vaccine in adolescent girls: A randomized clinical trial. Vaccine. 2016 Jan 12;34(3):313-9.
Cytomegalovirus (CMV) continues to be a significant cause of morbidity in neonates. Developing a vaccine to protect mothers against CMV could significantly improve the health of mothers and their offspring. This trial reports the experience of a large trial to evaluate the protective effect of a candidate vaccine against CMV.
Chen WH, Cohen MB, Kirkpatrick BD, Brady RC, Galloway D, Gurwith M, Hall RH, Kessler RA, Lock M, Haney D, Lyon CE, Pasetti MF, Simon JK, Szabo F, Tennant S, Levine MM. Single-dose Live Oral Cholera Vaccine CVD 103-HgR Protects Against Human Experimental Infection With Vibrio cholerae O1 El Tor. Clin Infect Dis. 2016 Jun 1;62(11):1329-35.
Cholera remains a common cause of severe diarrhea in many parts of the world resulting in an estimated 1.5 million cases annually and approximately 100,000 deaths/year. At the present, there is no vaccine licensed against cholera in the US. This trial was instrumental in the vaccine receiving approval from the FDA for use in travelers
Danziger-Isakov L, Frazier TW, Worley S, Williams N, Shellmer D, Dharnidharka VR, Gupta NA, Ikle D, Sweet SC; CTOTC-05 Consortium. Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation. Pediatr Transplant. 2016 Mar;20(2):307-15.
Non-adherence to medical recommendations has shown to be a major cause for failure of the graft. This project examined potential barriers to adherence and ways to improve adherence.
Fix AD, Harro C, McNeal M, Dally L, Flores J, Robertson G, Boslego JW, Cryz S. Safety and immunogenicity of a parenterally administered rotavirus VP8 subunit vaccine in healthy adults. Vaccine. 2015 Jul 17;33(31):3766-72.
In the US, currently licensed rotavirus (RV) vaccines have resulted in a markedly reduction in RV disease. However, the vaccines have not been as effective in parts of the developing world. This study provides us information to move us closer to testing in children of a new candidate vaccine against RV.