Wade SL, Taylor HG, Cassedy A, Zhang N, Kirkwood MW, Brown TM, Stancin T. Long-term Behavioral Outcomes after a Randomized, Clinical Trial of Counselor-Assisted Problem Solving for Adolescents with Complicated Mild-to-Severe Traumatic Brain Injury.J Neurotrauma. 2015 Jul1;32(13):967-75.
This paper reports the long-term behavioral outcomes from a randomized trial comparing online Counselor-Assisted Problem-Solving to access to internet resource regarding traumatic brain injury (TBI) in a cohort of 132 adolescents age 12-17 years hospitalized for TBI in six months before treatment. Findings provide evidence that Counselor Assisted Problem Solving associates with persistent improvements in behavior among older adolescents, and those with higher initial levels of symptoms.
Treble-Barna A, Zang H, Zhang N, Taylor HG, Yeates KO, Wade S. Long-Term Neuropsychological Profiles and their Role as Mediators of Adaptive Functioning after Traumatic Brain Injury in Early Childhood. J Neurotrauma. 2016 May 9.
This study examined the long-term neuropsychological profiles of children who sustained traumatic brain injury (TBI) in early childhood. Findings revealed that the impact of severe TBI on children’s long-term adaptive functioning is in part mediated by its effects on fluid reasoning and processing speed.
Kurowski BG, Wade SL, Dexheimer JW, Dyas J, Zhang N, Babcock L. Feasibility and Potential Benefits of a Web-Based Intervention Delivered Acutely After Mild Traumatic Brain Injury in Adolescents: A Pilot Study. J Head Trauma Rehabil. 2015 Sep 10.
Self-Management Activity-restriction and Relaxation Training (SMART) is a novel, web-based application of anticipatory guidance, psychoeducation, and cognitive-behavioral therapy that is feasible to initiate soon after mild traumatic brain injury (mTBI) in adolescents. Parents and adolescents, who used the program, reported it to be helpful and enjoyable. A web-based program potentially provides more convenient access to patients and families to treatment for mTBI than standard clinical care.
Evanson NK, Herman JP. Metabotropic glutamate receptor-mediated signaling dampens the HPA axis response to restraint stressPhysiol Behav. 2015 Oct 15;150:2-7.
Activation of the hypothalamus-pituitary-adrenal (HPA) axis mediates a significant portion of the hormonal response to stress. Glutamate, which is the main excitatory neurotransmitter in the brain, plays an activating role in regulating HPA axis activity. In these studies, we show that glutamate also exerts an inhibitory influence on HPA axis activity via group I metabotropic glutamate receptor signaling. These results highlight the complexity of glutamate signaling in regulation of HPA axis activity in response to stress.
Kurowski BG, Hugentobler J, Quatman-Yates C, Taylor J, Gubanich PJ, Altaye M, Wade SL. Aerobic Exercise for Adolescents With Prolonged Symptoms After Mild Traumatic Brain Injury: An Exploratory Randomized Clinical Trial. J Head Trauma Rehabil. 2016 Apr 26.
This novel, exploratory randomized clinical trial suggests sub-symptom exacerbation aerobic training is potentially beneficial for adolescents with persistent symptoms after mild traumatic brain injury (TBI). These findings indicate active-based rehabilitation approaches may facilitate recovery after mild TBI. This study provides a foundation for future work needed to determine the optimal type, timing, and intensity of active rehabilitation programs for mild TBI.