Vascular Dysfunction Relates to Reduced Exercise Capacity, Quality of Life for Fontan Survivors
Published Sept. 24, 2016
Journal of the American Heart Association
Complex Fontan surgery saves lives for infants born with severe congenital heart defects. However, as survivors grow into their adolescent and young adult years, increased arterial stiffness and decreased endothelial function appear to contribute to reduced aerobic capacity, physical activity, and quality of life.
In a cross-sectional study of 60 Fontan survivors, a research team led by Bryan Goldstein, MD, and Andrew Redington, MD, at Cincinnati Children’s, along with colleagues from Lurie Children's Hospital, evaluated patient capacity for exercise while tracking endothelial function and arterial stiffness. The team also examined quality of life measures.
In all cases, worse vascular measures were associated with worse functional measures.
This study is part of ongoing efforts to develop methods to prevent multisystem organ dysfunction among Fontan survivors. As patients reach adulthood, many develop “failing Fontan physiology,” which results from chronic exposure to low cardiac output and high central venous pressure.
“These results suggest that vascular function parameters could be important biomarkers of decreased functional performance. Furthermore, although these data cannot demonstrate a causal relationship, it is possible that abnormal vascular function itself is a determinant of functional performance and thus a potential therapeutic target to modify the inevitable functional decline observed in adolescent and young adult Fontan survivors,” the co-authors stated.
Early identification of Fontan patients at risk for failing physiology might allow for interventions to reduce the likelihood or to delay the rate of progression to symptomatic Fontan failure and the need for Fontan revision, conversion, or heart transplantation, the authors say.
The next step will be deeper studies to understand the cause–effect relationship between vascular function and functional outcomes.
