Academic and Research Committee (ARC) Awards

These grants support multi-disciplinary programs that can become self-sustaining within one to three years. Awardees this year are:

Topic PI Division Title
Education/Research Melissa Klein, MD/MEd | Dan Schumacher MD/MEd General & Community Pediatrics | Emergency Medicine Cincinnati Children's Hospital Medical Center Education Research Unit (CERU) and Educational Research Scholars Program
Clinical/Research Alexei Grom, MD | Grant Schulert, MD/PhD Rheumatology Cincinnati Autoinflammatory Disease (AIFD) Treatment and Research
Clinical/Research Jason Woods, PhD Pulmonary Medicine BPD Center of Excellence
Research Peter White, PhD | Marianne James Biomedical Informatics | IS Scalable and Sustainable Registry Project
Research Nathan Salomonis, PhD | Raphael Kopan, PhD Biomedical Informatics | Developmental Biology Cincinnati Pediatric Cell Atlas Center
Research Stephen Waggoner, PhD CAGE Kawasaki Disease—Diagnosis and Treatment
Clinical Michael Sorter, MD | Jennifer Ruschman Psychiatry | IS Center for Telehealth (ECHO)

Center for Clinical and Translational Science and Training (CCTST) Program Awards

Cincinnati Children’s partners with the University of Cincinnati and other institutions to support programs funded through the Center for Clinical and Translational Science and Training (CCTST). This list shows faculty who received grants to support translational research, build core capabilities, develop innovative research methods, or collaborate with community partners.

Type Title PI PI Department/Division Co-I Co-I Department/Division
Pilot Persistent Gene Expression Changes in Lung Macrophage Following Smoking Cessation Michael Borchers Pulmonary | Critical Care | and Sleep Medicine Mario Medvedovic, PhD Environmental Health
Pilot Targeting c-ABL as a novel strategy to treat vascular malformations Elisa Boscolo, PhD Experimental Hematology and Cancer Biology
Pilot Pilot Study of AZD7325 in Fragile X Syndrome Craig Erickson, MD Child Psychiatry
Pilot Mechanism-targeted treatment strategy in PTEN-associated autism and epilepsy Christina Gross, PhD Neurology
Pilot Cdc42 as a therapeutic target in multiple myeloma FuKun Guo, PhD Experimental Hematology and Cancer Biology Stephen Medlin Hematology-Oncology
Pilot SHARED DECISION-MAKING, PATIENT ENGAGEMENT AND ADHERENCE IN ADULTS WITH CF Patricia Joseph Pulmonary | Critical Care | and Sleep Medicine Mark Eckman General Internal Medicine
Pilot Injectable gel depot of simvastatin beta-hydroxy acid to treat low back pain Chia-Ying (James) Lin Biomedical Engineering Steve Agabegi Orthopaedic Surgery
Pilot Developing a Standardized Risk Assessment Approach to Improve School Safety Yizhao Ni, PhD Biomedical Informatics Drew Barzman, MD Psychiatry
Mentored Pilot Maternal diet during pregnancy and Diet-associated epigenetic markers Carina Venter Allergy and Immunology Marc Rothenberg, MD, PhD Allergy and Immunology
Mentored Pilot Targeted Combinatorial Treatment of BRAF-driven Melanoma Yuhang Zhang Pharmaceutical Science Zalfa Abdel-Malek Dermatology
JIT C1 Examining SCD methylation status as a biomarker for SCD inhibitor therapy in Glio Biplab DasGupta, PhD Oncology Hong Ji Asthma Research
JIT C1 Targeted sequencing of mouse and human angiosarcoma samples Jun-Lin Guan Cancer Biology
JIT C1 Comparability of exosomal RNA across human biofluids Scott Langevin Environmental Health / Epidemiology
JIT C1 Transcriptome Analysis of a Novel High-Risk B-ALL Inhibitor Nicholas Nassar Experimental Hematology & Cancer Biology José Cancelas Research & Experimental Hematology / Cancer Biology
Impact of Metabolic Health on Lactocyte Gene Expression Laurie Nommsen-Rivers College of Allied Health / Nutritional Sciences Aaron Marshall | Rebekah Karns Medical Education | Gastroenterology, Hepatology & Nutrition
JIT C1 C5a-C5aR1 function for brain storage of glucosylceramide in Gaucher disease Manoj Pandey, PhD Human Genetics
JIT C1 A Next-Century Approach to Cholesteatoma Treatment Ravi Samy Otology/Neurotology/ Skull Base Surgery / Otolaryngology-Head & Neck Surgery Brian Earl Communication Sciences & Disorders / Audiology
JIT C1 Modeling Inflammation and Fibrosis in Human with iPSC-derived Multi-Cellular Liver Organoid Takanori Takebe, MD Gastroenterology, Hepatology & Nutrition | Developmental Biology
JIT C2 Refrigerated preservation of human platelets Jose Cancelas-Perez, MD, PhD Experimental Hematology and Cancer Biology Yi Zheng, PhD Experimental Hematology and Cancer Biology
JIT C2 Genetic variation in cytolytic pathway and IFN induced cascade in Macrophage Activation Syndrome Alexei Grom, MD Rheumatology Sherry Thornton, PhD Rheumatology
JIT C2 Role of circadian rhythms in gastrointestinal systems Christian Hong Pharmacology and Systems Physiology
JIT C2 Re-evaluation of Xist repeat-B for X-chromosome inactivation Yuya Ogawa, PhD Reproductive Sciences
JIT C2 Single-cell RNAseq in Pediatric Ulcerative Colitis Michael Rosen, MD, MSCI Gastroenterology, Hepatology and Nutrition Nathan Salomonis, PhD Biomedical Informatics
JIT C3 Metabolomics Analysis of in vitro Co-culturing System for Pneumocystis (Pn) Melanie Cushion Infectious Diseases Nikeya Tisdale Infectious Diseases
JIT C3 Identifying marrow-stroma/leukemia cytokine crosstalk H. Leighton Grimes, PhD Immunobiology
JIT C3 Exploring Pseudohypoxia in Myelodysplastic Syndromes using Stable Isotope-Resolved Metabolomics Gang Huang, PhD Cancer Pathology
JIT C3 Generation of knock out mice for the long non coding RNA for Endothelin-1 Punam Malik, MD Experimental Hematology and Cancer Biology
Community Leaders Institute Place-Based Bike Clubs Jasmine Humphries
Community Leaders Institute Avondale Children Thrive Initiative Jodi Cunningham
Community Leaders Institute Healthy Cooking Club for Kids at Gabriel’s Place Michael Vinegar
Community Leaders Institute Health Effects of Stress on Youth Mildred Patterson
Community Leaders Institute Heal Through Creation—An Intentional Space for Single Women Nkem Kayla Iheukwu
Community Leaders Institute Uniting a Safe Sleep Ambassador Program in the Community (Collaboration with Cradle Cincinnati) Ruth Kelly
Community Leaders Institute Parent Connext Shermikao Datcher
Community Leaders Institute Through Another’s Eyes: Changing the Conversation about Recovery through Photovoice Tara Jimison
Community Leaders Institute Through Another’s Eyes: Changing the Conversation about Recovery through Photovoice Tyra Scherer
Community Leaders Institute Evidence-based Practices and Program Evaluation of Safe Pastures Family Home Life Skills Progra Valerie Bairnsfather
Community Leaders Institute-Advocate Avondale Children Thrive Initiative Tina Briggs-Brown
Community Leaders Institute-Advocate Avondale Children Thrive Initiative Jennifer Foster
Community Leaders Institute-Advocate Avondale Children Thrive Initiative Jeneya Lawrence
Community Leaders Institute-Advocate Avondale Children Thrive Initiative Audrey Scott
Community Leaders Institute-Advocate Walk With Me Priscilla Nash
Community Leaders Institute-Advocate Tree and Climate Education for Williams Avenue Elementary School and Neighborhood Dana Boll

Center for Pediatric Genomics Pilot Studies

The Center for Pediatric Genomics (CpG) has established a fund to distribute $1 million annually among projects that accelerate innovative research, development, and implementation of genomic science. Awardees this year are:

Faculty Division Title
Andrew Herr, PhD Immunobiology Defining the pediatric skin microbiome and its role in atopic dermatitis
Carlos Prada, MD Human Genetics Integrated metabolomics and genomics approach in the RASopathies
Ge Zhang MD, PhD Human Genetics An integrative approach to clinical variant prioritization and gene discovery
Leah Kottyan, PhD Center for Autoimmune Genomics and Etiology (CAGE) How does an amino acid change in IRF7 increase SLE risk?
Matthew Weirauch, PhD Center for Autoimmune Genomics and Etiology (CAGE) Expansion and enhancement of the CisBP transcription factor database
Michael Helmrath, MD Pediatric General and Thoracic Surgery Secretor status-related microbiota to predict Hirschsprung Disease outcomes
Nathan Salomonis, PhD Biomedical Informatics Targeting the spliceosome in AML oncofusions
Stephen Waggoner, PhD Center for Autoimmune Genomics and Etiology (CAGE) Defining the genomics of innate regulatory cell dysfunction in lupus
Tesfaye Mersha, PhD Asthma Research Molecular diagnosis of atopic dermatitis by transcriptome profiling of signature genes
Vivian Hwa, PhD | Takanori Takebe, MD Endocrinology | Gastroenterology, Hepatology & Nutrition Organoid models of endocrine growth disorder for personalized therapy testing

Children’s Health Research Career Development Award (CHRCDA)

This NICHD-funded program provides grants to support training physician-scientists to stimulate pediatric research across a variety of disciplines. This year’s awardees are:

Name Division Title of Research
Matthew Alder, MD, PhD Bone Marrow Transplantation & Immune Deficiency A Potential Role for olfm4 in Sepsis
Kathryn Weaver, MD Human Genetics Ttc21b Is Critical for Craniofacial Development
Andrew Lautz, MD Critical Care Medicine Developmental age-related mechanisms of sepsis-associated myocardial dysfunction
Maria Barnes Davis, MD, PhD Neonatology and Pulmonary Biology
Multimodal neuroimaging of the preterm language connectome: The Search for Biomarkers of Resiliency

Cincinnati Children's Innovation Fund

The Cincinnati Children’s Innovation Fund is designed to accelerate the commercialization of discoveries, innovations, projects or products. Recipients this year are:

Innovation Fund Category PI Title
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Small Molecule Therapy Craig Erickson, MD Pilot Signal Finding Study of AZD7325 in Adults with Fragile X Syndrome
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Diagnostics & Medical Devices Jose Peiro, MD | James Lin Shape-Memory Patch for Prenatal Spina Bifida Repair by Fetoscopic Approach
100% Innovation Fund Biologics Cell & Tissue Therapies Karnail Singh, PhD | Paul Spearman, MD Development and evaluation of a novel bivalent virus-like particle (VLP)-based Ebola vaccine
100% Innovation Fund Biologic, Cell & Tissue Therapies Ming Tan, PhD A Rotavirus Subunit Vaccine Based on the Novel Norovirus S Particle Platform
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Digital Health & Care Delivery John Perentesis, MD, FAAP Electronic cancer care navigation
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Biologic, Cell & Tissue Therapies Takanori Takebe, MD Validation human liver organoid based toxicity (LoT) screen in a dish
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Digital Health & Care Delivery Sander Vinks, PharmD, PhD Electronic health record embedded decision support platform for precision drug treatment in neonates
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Digital Health & Care Delivery Jing Xiang, MD, PhD MEG Processor
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Biologic, Cell & Tissue Therapies Yi Zheng, PhD | Jose Cancelas, MD, PhD Refrigerated preservation of platelets for human transfusion
50% Innovation Fund & 50% Ohio Third Frontier Technology Validation Startup Fund Diagnostic & Medical Device Assem Ziady, PhD Blood protein marker algorithms that predict lung function decline in CF and other pulmonary diseases

Alexion Rare Disease Innovation Fund

Alexion Pharmaceuticals and Cincinnati Children’s have established a collaboration to fund the advancement of research in rare disease. As in past years, Alexion has selected a recipient for the Alexion Rare Disease Innovation Award.

Fifth Third Bank/Charlotte R. Schmidlapp Women Scholars Awards

This program provides grants to support the academic career development of women faculty who have demonstrated academic potential and leadership skills as they progress toward the ranks of associate and full professor. This year’s awardees are:

Name Division Year
Theodosia Kalfa, MD, PhD Hematology 2017-2018
Rachel Thienprayoon, MD, PhD Clinical Anesthesia 2018-2019

GAP Funding Awards

This program provides one year of support to bridge gaps in R01-level funding or equivalent. Awardees this year are:

Name Division Title Funding Round
Rashmi Hegde, PhD Developmental Biology DNA damage repair signaling in Pulmonary Arterial Hypertension 2017 - July
Jennifer Kaplan, MD, MS Critical Care Role of STAT3 in sepsis-induced adipose tissue browning and the impact of obesity 2017 - July
Kakajan Komurov, PhD CBDI Loss of transcriptional fidelity in human cancers 2017 - July
Yuya Ogawa, PhD Reproductive Sciences Organization of the inactive X-chromosome 2017 - July
Grom Alexei, MD Rheumatology Clinical significance of genetic variation in the cytolytic pathway in MAS/sHLH 2017 - July
Adam Kiefer, PhD Sports Medicine Biofeedback-enhanced phenotypic plasticity to alter collision injury mechanisms 2017 - July
Rebecca Marsh, MD CBDI Precision dosing of Alemtuzumab in reduced intensity conditioning: a Pilot Study 2017 - July
Nathan Salomonis, PhD BMI Unbiased identification of spliceosome vulnerabilities across cancer 2017 - November
Mohammad Azam, PhD CBDI Role of FOS and DUSP1 in AML 2017 - November
Greg Tiao, MD Pediatric Surgery Genetic basis of virus induced biliary atresia 2017 - November
Rulang Jiang, PhD Dev Biol & Plastic Surgery Molecular patterning of the midface 2017 - November
Anna Esbensen, PhD DDBP Cognitive outcome measures in school-age children with Down Syndrome 2017 - November
Melinda Butsch Kovacic, MPH, PhD Asthma Research WE ENGAGE via Data & Stories to Improve Community Health & Foster STEM education 2018 - April
Tony De Falco, PhD Reproductive Sciences Exploring vascular-mesenchymal interactions in the stem cell niche 2018 - April
Leah Kottyan, PhD CAGE Transcription factor genetics in lupus 2018 - April
Steven Crone, PhD Neurosurgery Degeneration of respiratory circuits in ALS 2018 - April
Fukun Guo, PhD CBDI - Exp Hem RHoA in T cell mediated airway inflammation 2018 - April

Place Outcome Awards

This program, administered by the James M. Anderson Center for Health Systems Excellence, provides grants to stimulate the development of health services and quality improvement research at Cincinnati Children’s and to ensure optimal implementation of clinical and operational innovations in the care delivery system. Awardees receiving funding are:

PI Name Division Co PI Name Project Period Start Project Period End Award Title
Amanda Schondelmeyer, MD, MSc Hospital Medicine 7/1/2016 6/30/2018 Understanding continuous physiologic monitoring in hospitalized patients: A Mixed Methods Study
David Hartley, PhD, MPH Anderson Center/Emerg Med Nathan Timm, MD 7/1/2016 6/30/2018 Social media for early warning of epidemics
Rachel Thienprayoon, MD, MSCS Anesthesia 1/1/2017 12/31/2018 Identifying and defining caregiver and provider-prioritized domains of quality in pediatric hospice/palliative care
Daniel Schumacher, MD, Med Emergency Medicine Terri Byczkowski, PhD, MBA 7/1/2017 6/30/2019 Assocation between entrustment decisions and indicators of quality care (EDIQ) Entrustment Decision Tool Development
Lisa Hunter, PhD Communication Sciences Research Center John Clancy, MD 7/1/2017 6/30/2019 Clinical monitoring of Aminoglycoside Ototoxicity to improve safety and quality of life of outcomes in cystic fibrosis (AIM 1 Only)
Courtney Brown, MD, MSc General & Community Pediatrics 7/1/2017 6/30/2019 Rapid response intervention for children at risk of school suspension
Maya Dewan, MD, MPH Critical Care 1/1/2018 12/31/2019 Harnessing the power of the electronic health record to predict and prevent clinical deterioration in the Pediatric Intensive Care Unit
Elizabeth Enlow, MD, MS Neonatology 1/1/2018 12/31/2019 Patterns of infant health care use and parental needs after NICU discharge
Jason Long, PhD OT&PT Karen Harpster, PhD 1/1/2018 12/31/2019 Pilot Study: Addressing home-based functional challenges via telehealth-based OT
Nancy Daraiseh, PhD James M Anderson Center 6/1/2018 6/30/2020 Unit-based risk factors lining patient safety and employee safety
Amy Rule, MD, MPH Perinatal Institute Beena Kamath, MD, MPH 6/1/2018 6/30/2020 Microbial and clinical outcomes after reprocessing implementation in Kenya

Procter Scholar Grant

The Procter Scholar Program supports faculty members from the Departments of Pediatrics, Surgery, Radiology, Patient Services, and Anesthesia who are committed to pursuing academic research careers.

PI Division Grant Title
Theresa Alenghat, VMD, PhD Immunobiology Epigenomic regulation of inflammatory bowel disease
Grant Schulert, MD, PhD Rheumatology Monocyte and macrophage polarization in systemic JIA and MAS
Amy Shah, MD Endocrinology The effects of bariatric surgery on high density lipoprotein subspecies and their function
John Hutton, MD Gen Peds/Reading & Literacy Validation of a "novel" literacy screen tool and the neurobiology of rhyming
Pooja Khandelwal, MD CBDI/BMT Inhibition of lymphocyte trafficking as novel acute visceral GVHD prophylaxis in pediatrics
Lynn Lee, MD CBDI/Oncology The roles of MAP kinase activation and hematopoietic stem cell age in histiocytic neoplasms
Akihiro Asai, MD, PhD Gastroenterology Modeling inherited cholestasis with patient-specific mutations

Research, Innovation & Pilot (RIP) Funding Awards

This program provides grants to support collecting preliminary data for innovative and essential projects considered to be good candidates for future external funding. Awardees receiving funding this year include:

PI Division Grant Title Funding Round
Iouri Chepelev, PhD CAGE R168X mutation in MeCP2 links 3D chromatin structure and pre-mRNA splicing 2017 - July
Ge Zhang, MD, PhD Human Genetics Genetic basis of fetal drive for maternal physiological changes during pregnancy 2017 - July
Adam Kiefer, PhD Sports Medicine Genetic fuzzy artificial intelligence virtual reality training for collision-based injury prevention in sports 2017 - July
Gregory Lee, PhD Radiology/PNRC The effects of mild jugular vein compression collar on brain biomechanics and perenchymal stiffness: Development and validation of a novel ultra-high temporal resolution MRI imaging technique 2017 - July
Tesfaye Mersha, PhD Asthma Research Nasal microbiome composition and asthma risk among immigrants 2017 - July
Punam Malik, MD CBDI Improving homologous recombination by site-specific suppression of NHEJ 2017 - November
Katherine Yutzey, PhD HI - MCB Postnatal heart regeration in a young pocine model of cardiac injury 2017 - November
Erik Hysinger, MD, MS Pulmonary Medicine Quantitative MRI assessment of dynamic trachea collapse: Validation, energy expenditure and outcomes 2017 - November
Christopher Dandoy, MD, MSc CBDI Effect of Xylitol on oral health and bloodstream infection prevention during transplant 2017 - November
Christopher King, PhD Anesthesia Biological consequences of sleep disturbances in juvenile onset fibromyalgia 2017 - November
Greg Myer, PhD, FACSM, CSCS*D Sports Medicine Neural correlates of pain and sensorimotor control in patients with patellofemoral pain syndrome 2017 - November
Dean Beebe, PhD, ABPP BMCP Sleep after adolescent mild Traumatic Brain Injury: Nature, Contributors and a Pilot Clinical Trial 2018 - April
Tanya Froehlich, MD, MS, FAAP DDBP Epigenetics of Methylphenidate Effects in Children with ADHD 2018 - April
Catherine Gordon, MD, MSc Adolescent & Transition Medicine Bone density and marrow composition in transgender youth 2018 - April
Fukun Guo, PhD CBDI - Exp Hem Cdc42 regulated Treg stability in tumor immune evasion 2018 - April

Trustee Grant Awards

This program provides research funds for junior faculty to support rapid achievement of independent, sustained extramural funding for their research. This year’s awardees are:

PI Division Grant Title
Jun (Goto) Nakamura, PhD Neurosurgery Molecular characterization of choroid plexus cilia in a novel mouse mutant with communicating hydrocephalus
Philip Minar, MD Gastroenterology Molecular signature to predict response to biologic therapy in pediatric Crohn's
Yutaka Maeda, DVM, PhD Pulmonary Biology Mechanism of NKX2-1-Mediated suppression of airway hyper-secretion
Jennifer Schumacher, PhD Developmental Biology Roles of the adaptor protein She in Vegf signaling and vascular maintenance
Ting Wen, MD, PhD Allergy & Immunology Investigating the roles of FFAR3 in Th2 cytokine production by esophageal lymphocytes
Emily Miraldi, PhD Immunobiology Transcription regulatory network inference from single-cell genomics measurements
Soona Shin, PhD Pediatric General & Thoracic Surgery The paracrine role of hepatic progenitor cells in liver cancer
Nathan Salomonis, PhD BMI New targets for spliceosome therapy in human AML
Paritha Arumugam, PhD Neonatology & Pulmonary Biology Macrophage engraftment/maintenance and the durability of PMT therapeutic efficacy
Yueh-Chiang Hu, PhD Developmental Biology Differentiation of primordial germ cells by the genital ridge via BMP signaling
Yizhao Ni, PhD BMI BRIDGE: A Brain Image-Descriptor Generation Model to assist brain tumor evaluation
Lisa Privette-Vinnedge, PhD CBDI, Oncology Mechanisms coupling DEK to Wnt signaling and oncogenesis
Rachelle Ramsey, PhD Behavioral Medicine & Clinical Psychology Using technology-assisted stepped care intervention to improve adherence in adolescents with asthma