DeMartini, T; Nowell, M; James, J; Williarnson, L; Lahni, P; Shen, H; Kaplan, JM. High fat diet-induced obesity increases myocardial injury and alters cardiac STAT3 signaling in mice after polymicrobial sepsis. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017; 1863(10):2654-2660.
Obesity is a significant health problem. Results from the current study, together with published data from our laboratory, suggest that obesity is detrimental during murine sepsis. In this study, we found that obesity affects cardiac function and leads to cardiac injury after sepsis. The mechanism of myocardial injury is, in part, through activation of the STAT3 pathway.
Stenson, EK; Cvijanovich, NZ; Anas, N; Allen, GL; Thomas, NJ; Bigham, MT; Weiss, SL; Fitzgerald, JC; Checchia, PA; Meyer, K; Quasney, M; Hall, M; Gedeit, R; Freishtat, RJ; Nowak, J; Raj, SS; Gertz, S; Grunwell, JR; Wong, HR. Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock. Pediatric Critical Care Medicine. 2018; 19(2):155-160.
This is the first manuscript reporting that hyperchloremia is an independent risk factor for mortality among children with septic shock. Since hyperchloremia is a modifiable clinical variable, the study has the potential to positively change clinical practice.
Wong, HR; Cvijanovich, NZ; Anas, N; Allen, GL; Thomas, NJ; Bigham, MT; Weiss, SL; Fitzgerald, JC; Checchia, PA; Meyer, K; Quasney, M; Hall, M; Gedeit, R; Freishtat, RJ; Nowak, J; Raj, SS; Gertz, S; Grunwell, JR; Lindsell, CJ. Improved risk stratification in pediatric septic shock using both protein and mRNA Biomarkers: Persevere-XP. American journal of respiratory and critical care medicine. 2017; 196(4):494-501.
This manuscript reports a new and improved stratification model for pediatric septic shock that includes both protein and mRNA biomarkers. The stratification model has the potential to serve as a reliable prognostic enrichment tool to enable precision critical care medicine for children with septic shock.
Yehya, N; Wong, HR. Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine. 2018; 46(1):e9-e16.
This manuscript reports a new stratification model for pediatric acute respiratory distress syndrome (PARDS). The stratification model has the potential to serve as a reliable prognostic enrichment tool to enable precision critical care medicine for children with PARDS.