Jodele, S; Dandoy, CE; Myers, K; Wallace, G; Lane, A; Teusink-Cross, A; Weiss, B; Davies, SM. High-dose CarboplatinEtoposideMelphalan increases risk of thrombotic microangiopathy and organ injury after autologous stem cell transplantation in patients with neuroblastoma. Bone Marrow Transplantation. 2018; 53(10):1311-1318.
This paper is the first description of the important and particular association of thrombotic microangiopathy.
Lounder, DT; Khandelwal, P; Gloude, NJ; Dandoy, CE; Jodele, S; Medvedovic, M; Denson, LA; Lane, A; Lake, K; Litts, B; Wilkey, A; Davies, SM. Interleukin-22 levels are increased in gastrointestinal graft-versus-host disease in children. Haematologica: the hematology journal. 2018; 103(10):haematol.2017.174771-haematol.2017.174771.
Elevation of interleukin-22 levels are well described in mice, but not previously shown in humans. This study reports this elevation for the first time, identifying a new druggable target.
Wallace, G; Jodele, S; Myers, KC; Dandoy, CE; El-Bietar, J; Nelson, A; Teusink-Cross, A; Khandelwal, P; Taggart, C; Gordon, CM; Davies, SM; Howell, JC. Single Ultra-High-Dose Cholecalciferol to Prevent Vitamin D Deficiency in Pediatric Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation. 2018; 24(9):1856-1860.
Vitamin D deficiency worsens outcomes of transplant. Treating Vitamin D deficiency in children is difficult, as the children have vomiting and diarrhea. This study demonstrates safety and efficacy of a single large dose of Vitamin D given before transplant starts.
Walkup, LL; Myers, K; El-Bietar, J; Nelson, A; Willmering, MM; Grimley, M; Davies, SM; Towe, C; Woods, JC. Xenon-129 MRI detects ventilation deficits in paediatric stem cell transplant patients unable to perform spirometry. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2019; 53(5):000-000.
This paper describes a novel imaging modality to identify lung injury in transplant patients. This work is an important ongoing collaboration between bone marrow transplantation and pulmonology.