Ramsey, RR; Holbein, CE; Powers, SW; Hershey, AD; Kabbouche, MA; O'Brien, HL; Kacperski, J; Shepard, J; Hommel, KA. A pilot investigation of a mobile phone application and progressive reminder system to improve adherence to daily prevention treatment in adolescents and young adults with migraine. Cephalalgia: an international journal of headache. 2018; 38(14):2035-2044.
Adherence to recommended treatment for migraine can have a significant impact on outcomes. This study utilized an adherence reminder system using a mobile phone application and provides a proof on concept of the benefit of adherence management.
Krueger, DA; Capal, JK; Curatolo, P; Devinsky, O; Ess, K; Tzadok, M; Koenig, MK; Narayanan, V; Ramos, F; Jozwiak, S; de Vries, P; Jansen, AC; Wong, M; Mowat, D; Lawson, J; Bruns, S; Franz, DN; TSCure Research Group. Short-term safety of mTOR inhibitors in infants and very young children with tuberous sclerosis complex TSC Multicentre clinical experience. European Journal of Paediatric Neurology. 2018; 22(6):1066-1073.
Tuberous sclerosis complex can begin to impact the developing brain prior very early. mTOR inhibitors can help treat the symptoms of TSC, but may have an impact themselves. This study demonstrated that although adverse events were common, they tended to be mild and did not prevent their use, setting the stage for an early intervention study prior to symptom initiation.
Orr, SL; Kabbouche, MA; O'Brien, HL; Kacperski, J; Powers, SW; Hershey, AD. Paediatric migraine evidence-based management and future directions. Nature Reviews Neurology. 2018; 14(9):515-527.
Management of migraine in adults and children is rapidly changing with results of recent studies increasing the confusion and need for improved analysis. This paper reviewed the current state of knowledge and provided guidance for future study, guidelines and protocols to reduce this barrier to determination of the most effective care.
Jain, SV; Dye, T; Kedia, P. Value of combined video EEG and polysomnography in clinical management of children with epilepsy and daytime or nocturnal spells. Seizure: European Journal of Epilepsy. 2019; 65:5-Jan.
Sleep disorders and epilepsy may have a bi-directional negative impact - sleep problems increasing seizure risk and seizures disrupting sleep. This study analyzed combined vEEG with polysomnography to further elucidate this interaction and the need for expanding the role of these combined studies.