Blood and tissue eosinophilia are associated with a number of infectious and inflammatory diseases. Corticosteroids are effective in reducing eosinophil numbers, but patients often develop resistance and toxic side effects from this non-specific treatment.
Exciting new roles for eosinophils have been discovered in regulating local immune responses and supporting specialized niches. Therefore, treatments that specifically target eosinophils are likely to be effective in modulating a number of prevalent diseases in allergy, autoimmunity and malignancy.
There is a growing need for development of safe and effective therapies that specifically target eosinophils. The aim of our research is to identify novel therapeutic targets to block eosinophil production and prevent the release of mature eosinophils from the bone marrow.
Eosinophils, like all blood cells, are produced in the bone marrow from hematopoietic stem cells (HSC). The common myeloid progenitor (CMP) is derived from HSCs and gives rise to all myeloid lineages, including eosinophils. Eosinophil lineage-committed progenitors (EoP) differentiate exclusively into fully mature eosinophils whereas granulocyte-monocyte progenitors (GMP) differentiate into neutrophils and monocytes/macrophages. Studies focused on understanding EoP biology may reveal new therapeutic targets for specifically regulating eosinophil production in the bone marrow.