The FETAL (Family and Environment in Timing for Abnormal Labor) Study project at Cincinnati Children’s and the University of Cincinnati seeks to:

  • Analyze data from first-degree relatives of mothers delivering preterm to show the existence of a genetic connection to premature delivery
  • Estimate the prevalence of preterm delivery in families
  • Establish a registry of familial preterm delivery syndromes with blood samples linked to general health and environmental information
  • Analyze the registry using new genetic and genomic tools
  • Determine if familial preterm delivery syndromes have associated maternal / fetal phenotypes 

Our Hypotheses 

  • Preterm delivery syndromes exist in families.
  • Mutations or polymorphisms in specific genes contribute to a significant number of premature births.
  • Specific maternal / fetal phenotypes are associated with familial preterm delivery syndromes. 

How Is the Project Funded? 

Major support for this project is provided by: 

Past support has been received from:

Who Is Eligible for the Study? 

Women who have given birth between 20 and 34 weeks’ gestation and meet the following criteria may be eligible for this study: 

  • The patient is a pregnant female who delivered a live infant.
  • The patient delivered between 20 and 34 weeks. Gestational age will be defined by figuring the first day of the last menstrual period or results of the measurement obtained at the first ultrasound examination.
  • The patient does not have a history that includes any study exclusion criteria.