Building a Transdisciplinary Investigative Team

The March of Dimes Prematurity Research Center Ohio Collaborative

The March of Dimes Prematurity Research Center Ohio Collaborative includes more than 100 faculty-level investigators, trainees and staff and is led by Louis Muglia, MD, PhD, Cincinnati Children’s Hospital Medical Center; Irina Buhimschi, MD, Ohio State University and Nationwide Children’s Hospital; and Sam Mesiano, PhD, Case Western Reserve University.  

Five key research themes are being pursued via transdisciplinary interactions that will generate new research hypotheses and techniques to prevent preterm birth.

Research Areas

Evolutionary Synthesis of Human Pregnancy

 
Leaders Division or Department Institution
Antonis Rokas, PhD Biological Sciences Vanderbilt University
Patrick Abbot, PhD Biological Sciences Vanderbilt University
Kenneth Petren, PhD Biological Sciences University of Cincinnati
Co-Investigators and Collaborating Faculty
Danielle Bessett, PhD Sociology University of Cincinnati
Mark Chance, PhD Center for Proteomics and Bioinformatics Case Western
Emily DeFranco, DO, MSCR Obstetrics and Gynecology UC College of Medicine
James Greenberg, MD Perinatal Institute Cincinnati Children’s
Joshua Gross, PhD Biological Sciences University of Cincinnati
Brian Mercer, MD Obstetrics and Gynecology Case Western / MetroHealth
Mihaela Pavlicev, PhD Perinatal Institute Cincinnati Children’s
Raymond Redline, MD Pathology Case Western
Katherine Whitcome, PhD Anthropology University of Cincinnati

Genetics of Unique Human Populations

 
Leaders Division or Department Institution
Louis Muglia, MD, PhD Perinatal Institute Cincinnati Children’s
John Harley, MD, PhD Center for Autoimmune Genomics and Etiology Cincinnati Children’s
Scott Williams, PhD Center for Integrative Biomedical Sciences Dartmouth College
Co-Investigators and Collaborating Faculty
Justin Fay, PhD Center for Genome Sciences Washington University
John Hutton, MD Biomedical Informatics Cincinnati Children’s
Jay Iams, MD Obstetrics and Gynecology Ohio State University
Farrah Jacquez, PhD Psychology University of Cincinnati
Douglas Kniss, PhD Obstetrics and Gynecology Ohio State University
Jennifer Malat, PhD Sociology University of Cincinnati
Mihaela Pavlicev, PhD Perinatal Institute Cincinnati Children’s
Rita Pickler, PhD, RN Center for Professional Excellence Cincinnati Children’s
Raymond Redline, MD Pathology Case Western
Kelli Ryckman, PhD Epidemiology University of Iowa
Ge Zhang, PhD Human Genetics Cincinnati Children’s

The Molecular Developmental Biology of Pregnancy

 
Leaders Division or Department Institution
SK Dey, PhD Reproductive Sciences Cincinnati Children’s
Kenneth Campbell, PhD Developmental Biology Cincinnati Children’s
Jeffrey Whitsett, MD Perinatal Institute Cincinnati Children’s
Co-Investigators and Collaborating Faculty
Thomas Brown, PhD Neuroscience, Cell Biology & Physiology Wright State University
Mark Chance, PhD Center for Proteomics and Bioinformatics Case Western
Takiko Daikoku, PhD Reproductive Sciences Cincinnati Children’s
Sanjoy Das, PhD Reproductive Sciences Cincinnati Children’s
Ken Greis, PhD Cancer and Cell Biology UC College of Medicine
Mounira Habli, MD Cincinnati Fetal Center Cincinnati Children’s
Beena Kamath-Rayne, MD, MPH Perinatal Institute Cincinnati Children’s
Douglas Kniss, PhD Obstetrics and Gynecology Ohio State University
Charles Lockwood, MD Obstetrics and Gynecology University of South Florida
Sam Mesiano, PhD Obstetrics and Gynecology Case Western / University Hospitals Case Medical Center
Sing Sing Way, MD, PhD Infectious Diseases Cincinnati Children’s

Progesterone Signaling in Pregnancy Maintenance and Preterm Birth

 
Leaders Division or Department Institution
Catalin Buhimschi, MD Obstetrics and Gynecology Ohio State University
Sam Mesiano, PhD Reproductive Biology Case Western / University Hospitals Case Medical Center
Douglas Kniss, PhD Obstetrics and Gynecology Ohio State University
Co-Investigators and Collaborating Faculty
William Ackerman, MD Obstetrics and Gynecology Ohio State University
Mark Chance, PhD Center for Proteomics and Bioinformatics Case Western
SK Dey, PhD Reproductive Sciences Cincinnati Children’s
Ozlem Guzeloglu-Kayisli, PhD Obstetrics and Gynecology University of South Florida
Jay Iams, MD Obstetrics and Gynecology Ohio State University
Umit A Kayisli, PhD Obstetrics and Gynecology University of South Florida
Charles Lockwood, MD Obstetrics and Gynecology University of South Florida
Brian Mercer, MD Obstetrics and Gynecology MetroHealth / Case Western
John Moore, MD Neonatology MetroHealth / Case Western
Louis Muglia, MD, PhD Perinatal Institute Cincinnati Children’s
Raymond W. Redline, MD Pathology Case Western
Frederick Schatz, PhD Obstetrics and Gynecology University of South Florida
Honor Wolfe, MD Obstetrics and Gynecology Case Western / University Hospitals Case Medical Center

Sociobiology of Racial Disparities in Preterm Birth

 
Leaders Division or Department Institution
Irina Buhimschi, MD Center for Perinatal Research Nationwide Children’s
Jennifer Malat, PhD Sociology University of Cincinnati
Brian Mercer, MD Obstetrics and Gynecology MetroHealth / Case Western
Co-Investigators and Collaborating Faculty
Michael Bailey, PhD Microbial Interface Biology Ohio State University
Danielle Bessett, PhD Sociology University of Cincinnati
Catalin Buhimschi, MD Obstetrics and Gynecology Ohio State University
Lisa Christian, PhD Psychiatry and Psychology Ohio State University
David Greenberg, PhD Neurogenetics Nationwide Children’s
James Greenberg, MD Perinatal Institute Cincinnati Children’s
Eric Hall, PhD Perinatal Institute
Biomedical Informatics
Cincinnati Children’s
Jay Iams, MD Obstetrics and Gynecology Ohio State University
Farrah Jacquez, PhD Psychology University of Cincinnati
Sarah Keim, PhD Biobehavioral Health Nationwide Children’s
Elizabeth Kelly, MD Obstetrics and Gynecology UC College of Medicine
Mark Klebanoff, MD, MPH Center for Perinatal Research Nationwide Children’s
Courtney Lynch, PhD, MPH Obstetrics and Gynecology Ohio State University
Louis Muglia, MD, PhD Perinatal Institute Cincinnati Children’s
Patricia Reagan, PhD Human Resource Research Ohio State University
Kent Schwirian, PhD Sociology Ohio State University
Patricia Schwirian, PhD, RN College of Nursing Ohio State University
Honor Wolfe, MD Obstetrics and Gynecology Case Western / University Hospitals Case Medical Center

Recent Publications

Kim J, Stirling KJ, Cooper ME, Ascoli M, Momany AM, McDonald EL, Ryckman KK, Rhea L, Schaa KL, Cosentino V, Gadow E, Saleme C, Shi M, Hallman M, Plunkett J, Teramo KA, Muglia LJ, Feenstra B, Geller F, Boyd HA, Melbye M, Marazita ML, Dagle JM, Murray JC. Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study. BMC Med Genet. 2013; 14: 77.

Laryea G, Schutz G, Muglia LJ. Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity. Mol Endocrinol. 2013; 27: 1655-1665.

Chun S, Plunkett J, Teramo K, Muglia LJ, Fay JC. Fine-mapping an association of FSHR with preterm birth in a Finnish population. PLoS ONE 2013; 8: e78032.

Louderback K, Wills TA, Muglia LJ, Winder DG. Knockdown of BNST Glu2B-containing NMDA receptors mimics the actions of ketamine on novelty-induced hypophagia. Translational Psychiatry 2013; 3: e331.

Zhang G, Muglia LJ, Chakraborty R, Akey JM, Williams SM. Signatures of natural selection on genetic variants affecting complex human traits. Applied and Translational Genomics 2013; 2:77-93.

Cha J, Bartos A, Egashira M, Haraguchi H, Saito-Fujita T, Leishman E, Bradshaw H, Dey SK, Hirota Y.  Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions.  J Clin Invest. 2013 Sep 3;123(9):4063-75. doi: 10.1172/JCI70098. Epub 2013 Aug 27.  

McElroy JJ, Gutman CE, Shaffer CM, Busch TD, Puttonen H, Teramo K, Murray JC, Hallman M, Muglia LJ.  Maternal coding variants in complement receptor 1 and spontaneous idiopathic preterm birth.  Hum Genet. 2013 Apr 17. [Epub ahead of print]

Rowe JH, Ertelt JM, Xin L, Way SS. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature. 2012 Oct 4;490(7418):102-6.