Inflammatory and Diarrheal Diseases
Jennifer Kaplan, MD, MS
Department of Pediatrics; Division of Critical Care
Description of Research
Dr. Kaplan’s research focuses on understanding the inflammatory response associated with sepsis. The nuclear receptor PPARg is important in controlling the inflammatory response in animal models of sepsis and in critically ill children with sepsis. She demonstrated that in children with sepsis the adipokines adiponectin and resistin are altered. Dr. Kaplan’s current research focuses on the increased susceptibility of diet-induced obese mice to sepsis by focusing on the critical links between the inflammatory pathways in sepsis and obesity.
Collaborations and Core Use
Dr. Kaplan is working with Drs. Zingarelli and Morrow studying the inflammatory pathways in obesity, sepsis and inflammatory bowel disease. Anticipated use of Cores: Integrative Morphology and Gene and Protein Expression Cores.