Steven S. Potter, PhD
Professor, Director of Gene and Protein Expression Core
Department of Pediatrics; Division of Developmental Biology
Visit the Potter Lab
Description of Research
Dr. Potter is the Director of the Gene and Protein Expression Core and collaborates with DHC investigators to study intestinal development. Dr. Potter is also the PI of a research program focused on kidney development. His overall research strategy investigates the genetic pathways that drive organogenesis, with particular interest in genes that occupy upper level positions in the genetic hierarchy of development. Among these are the Hox genes, dispersed homeobox genes, zinc finger transcription factors, and other transcription factor genes, as well as growth factors and their signal transduction pathways. He has generated targeted mice with mutations in Hoxa 11, Gsh-1, Gsh-2, c-myb, Sp4, Sp8, Lhx4, PygI, PygII, Lrd, Prx1, and Npas3 and studied the resulting developmental defects. He also uses microarrays to define downstream targets of transcription factors, to provide a global analysis of mutant phenotypes, and to create an atlas of normal gene expression states during organogenesis.
Dr. Potter has ongoing collaboration with Drs. Aronow, and Wiginton to study the transcriptome of the developing kidney, intestine, and intestinal epithelial cell lines.