Randy J. Seeley, PhD
Director of the Metabolic Disease Institute
Department of Internal Medicine; Division of Endocrinology, Diabetes and Metabolism

Description of Research

Dr. Seeley’s research has focused on the actions of various hormones in the regulation of food intake, body weight and the regulation of circulating fuels. In particular, he has focused upon the numerous hypothalamic and gastrointestinal peptides and their associated receptors that influence both energy intake as well as peripheral metabolic processes with a focus on developing new treatment strategies for obesity. A large part of his work includes dissecting the biological effects of various bariatric surgical procedures to cause weight loss and improve glucose control using rodent models.


Dr. Seeley collaborates with Drs. Woods, Kohli, and D’Alessio studying the role of key gut hormones to regulate food intake and glucose regulation. He also works with Dr. Kohli examining the role that diets high in saturated fat and fructose have in the development of obesity and nonalcoholic steatohepatitis. Anticipated Core use: Integrative Morphology Core.