Quantification of PAO Accumulation in Human Cardiomyopathy Specimens
In this project we are studying hearts explanted from adults with end stage heart failure due to ischemic cardiomyopathy or dilated cardiomyopathy. Using an antibody that recognizes a PAO conformer, we are able to quantify the amount of myocardium occupied by PAO. Correlations of PAO accumulation with markers of altered intracellular homeostasis, patient age, clinical cardiac status and comorbidities are also focuses of this project.
Funding: RO1 HL087862-01A1
Principle Investigator: Jeffrey Robbins NIH / NHLBI
Echocardiography of Murine Species
The Mouse Echocardiography Core is currently supporting a variety of mouse and rat cardiac projects in molecular cardiovascular biology including studies of hypertrophic and dilated cardiomyopathies, congenital cardiac malformations and cardiac valve dysfunction. In addition to adult and juvenile mouse echocardiography, detailed anatomic and functional studies are also performed in fetal rats and mice.