Robbins Lab

Qi, L; Zang, H; Wu, W; Nagarkatti, P; Nagarkatti, M; Liu, Q; Robbins, J; Wang, X; Cui, T. CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes. Journal of Molecular and Cellular Cardiology. 2020; 145:59-73.

Xu, N; Gulick, J; Osinska, H; Yu, Y; McLendon, PM; Shay-Winkler, K; Robbins, J; Yutzey, KE. Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination. Circulation Research. 2020; 126:907-922.

Baker, RS; Zafar, F; Kimura, N; Knilans, T; Osinska, H; Robbins, J; Taylor, M; Morales, DL S. In Vivo Remodeling of an Extracellular Matrix Cardiac Patch in an Ovine Model. ASAIO Journal. 2019; 65:744-752.

Robbins, J; James, J. Myocardium and Development. In: Wernovsky G; Anderson RH; Krishna K; Mussato KA; Redington A; Tweddell JS; Tretter J, Ed. Anderson's Pediatric Cardiology. Philadelphia, PA: Elsevier; 2019.

Zheng, D; Su, Z; Zhang, Y; Ni, R; Fan, G; Robbins, J; Song, L; Li, J; Peng, T. Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity. Archives of Toxicology. 2019; 93:1051-1065.

Meng, Q; Bhandary, B; Bhuiyan, MS; James, J; Osinska, H; Valiente-Alandi, I; Shay-Winkler, K; Gulick, J; Molkentin, JD; Blaxall, BC; et al. Myofibroblast-Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Circulation Research. 2018; 123:1285-1297.

Lowey, S; Bretton, V; Joel, PB; Trybus, KM; Gulick, J; Robbins, J; Kalganov, A; Cornachione, AS; Rassier, DE. Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115:11238-11243.

Abdullah, CS; Alam, S; Aishwarya, R; Miriyala, S; Panchatcharam, M; Bhuiyan, MA N; Peretik, JM; Orr, AW; James, J; Osinska, H; et al. Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics. Journal of the American Heart Association. 2018; 7.

Bhandary, B; Meng, Q; James, J; Osinska, H; Gulick, J; Valiente-Alandi, I; Sargent, MA; Bhuiyan, S; Blaxall, BC; Molkentin, JD; et al. Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -β Signaling. Journal of the American Heart Association. 2018; 7.

Alam, S; Abdullah, CS; Aishwarya, R; Miriyala, S; Panchatcharam, M; Peretik, JM; Orr, AW; James, J; Robbins, J; Bhuiyan, MS. Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity. Journal of the American Heart Association. 2018; 7.

Singh, SR; Robbins, J. Desmin and Cardiac Disease: An Unfolding Story. Circulation Research. 2018; 122:1324-1326.

Singh, SR; Zech, AT L; Geertz, B; Reischmann-Duesener, S; Osinska, H; Prondzynski, M; Kraemer, E; Meng, Q; Redwood, C; van der Velden, J; et al. Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice. Circulation: Heart Failure. 2017; 10.

Meng, Q; Bhandary, B; Osinska, H; James, J; Xu, N; Shay-Winkler, K; Gulick, J; Willis, MS; Lander, C; Robbins, J. MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C. Journal of the American Heart Association. 2017; 6.

McLendon, PM; Davis, G; Gulick, J; Singh, SR; Xu, N; Salomonis, N; Molkentin, JD; Robbins, J. An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. Circulation Research. 2017; 121:604-616.

Pleasant, L; Ma, Q; Devarajan, M; Parameswaran, P; Drake, K; Siroky, B; Shay-Winkler, K; Robbins, J; Devarajan, P. Increased susceptibility to structural acute kidney injury in a mouse model of presymptomatic cardiomyopathy. American Journal of Physiology - Renal Physiology. 2017; 313:F699-F705.

Xu, N; Bitan, G; Schrader, T; Klaerner, F; Osinska, H; Robbins, J. Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. Journal of the American Heart Association. 2017; 6.