Our laboratory currently has several on-going projects with collaborators throughout the United States. We are actively pursuing these projects to further understand a unique aspect of hydrocephalus in children. If you are interested in learning more details about these projects or contributing to our lab’s efforts, please contact us.

Ciliopathy mouse models for hydrocephalus

Utilizing our mouse models for cilia defects (ciliopathies), we are dissecting out the molecular and signaling events underlying the genesis of hydrocephalus during development. We have formed a core group of cilia-related experts to aid in these investigations. For these projects we have access to world-class imaging center at Cincinnati Children’s and the extensive expertise of the investigators in the Developmental Biology program.

Collaborators: Kenneth Campbell, Masato Nakafuku, Rolf Stottmann, Samantha Brugmann, Q. Richard Lu

Funding: Hydrocephalus Association

Imaging of Cilia

We have established on-going translational and basic science investigations based in Boston and Cincinnati Children’s for the study of cilia at the subcellular level. Utilizing developing microscopic technology, we have identified novel way to study ependymal cilia function and responsiveness to changes in physiology.

Collaborators: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard University

Funding: Wellman Center

Human genetics and molecular genetics studies

We have ongoing IRB approved studies to help us better understand the genetic pathways involved in various forms of hydrocephalus. We have ongoing clinical, translational, and basic science projects based on our excellent pediatric and pediatric neurosurgical care at Cincinnati Children’s.

Collaborators: St. Louis Children’s Hospital and the University of Iowa

Funding: Cincinnati Children’s Hospital Medical Center