March of Dimes – Innovation catalyst grant (Kallapur PI)
01/01/15 – 12/31/16
Neutrophils and mechanisms of preterm labor
This study will define the role of neutrophils that infiltrate in the chorio-decidua during chorioamnionitis in initiating preterm labor. This grant will use intraamniotic injection of LPS to induce chorioamnionitis in non-human primates, in collaboration with Dr. Lisa Miller at the California National Primate Center, UC Davis.
Burroughs Wellcome Fund - 1012534 (Chougnet PI, Kallapur Co-PI) 7/1/13 – 6/30/17
Host-microbe cross-talk and pregnancy outcomes
This grant will study mechanisms and maternal/fetal immunology in the causation or initiation of preterm labor in a rhesus macaque model of chorioamnionitis induced by intraamniotic injection of live Ureaplasma parvum. The project is in collaboration with Dr. Lisa Miller, PhD, at the California National Primate Center, UC Davis CA.
NIH R01 HD072842 (Jobe PI, Kallapur Co-investigator) 08/01/12 – 05/31/17
Initiation and Progression of Preterm Lung Injury with Ventilation
This new grant will explore how the elements of mechanical ventilation (tidal volume, recruitment strategies, pressure) injure the fetal sheep lung. Ventilation induced injury will be characterized by the acute injury responses followed by their progression and resolution – with a focus on airway injury.
NIH R01 NR012307 (Pickler PI, Kallapur Co-investigator) 03/03/11 – 02/29/16
Patterned Experience for Preterm Infants
The primary aim of this study is to test the effect of a PFE on neurobehavioral organization at three time points: the transition to oral feedings, NICU discharge, and 2 months corrected age (48 weeks PMA) in a randomized trial. The secondary aims are to the test the effect of a PFE on cognitive function at 6 months corrected age, neurobehavioral development; and clinical outcomes.
NIH-HD R01-57869 (Kallapur PI) 02/03/2009 – 01/31/2015
Mechanisms of fetal systemic inflammatory response syndrome induced by chorioamnionitis
This project will study the pathogenesis of fetal systemic inflammatory response syndrome (FIRS) in preterm fetuses exposed to endotoxin induced chorioamnionitis in sheep. The grant will also evaluate the fetal innate immune responses to chorioamnionitis and how endotoxin tolerance modulates FIRS.
NIH-HL R01-97064 (Kallapur & Jobe, joint PIs) 9/24/2009 – 7/31/2013
Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease
This project will study the pulmonary outcomes and immune modulation after exposure to Ureaplasma chorioamnionitis. The human component will evaluate late-preterm infants born between 32-37 week gestation and evaluate lung outcomes at 9 months and 2 years. The animal component will utilize a preterm sheep model and evaluate lung outcomes at 2 months.