Developmental Biology
Brugmann Lab

The Brugmann Research Lab

Craniofacial abnormalities comprise approximately one-third of all birth defects. Our lab aims to understand the molecular forces that drive craniofacial development and elucidate the molecular basis for diseases that affect the craniofacial complex. To understand the forces that help pattern the face during normal and abnormal development we utilize various model systems with unique facial morphologies.

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Publications

2023

Halurkar, MS; Inoue, O; Mukherjee, R; Paese, CL B; Duszynski, M; Brugmann, SA; Lim, H; Sanchez-Gurmaches, J. The widely used Ucp1-CreEvdr transgene elicits complex developmental and metabolic phenotypes. 2023; 4:2023.10.20.563165.

Elliott, KH; Balchand, SK; Paese, CL B; Chang, CF; Yang, Y; Brown, KM; Rasicci, DT; He, H; Thorner, K; Chaturvedi, P; et al. Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation. Development (Cambridge). 2023; 150:dev201237.

2022

Paese, CL B; Chang, CF; Kristeková, D; Brugmann, SA. Pharmacological intervention of the FGF-PTH axis as a potential therapeutic for craniofacial ciliopathies. DMM Disease Models and Mechanisms. 2022; 15:dmm049611.

Brugmann, SA; Merrill, AE; Saint-Jeannet, JP; Stottmann, RW; Clouthier, DE. The Society for Craniofacial Genetics and Developmental Biology 44th Annual Meeting. American Journal of Medical Genetics, Part A. 2022; 188:2258-2266.

2021

Pagliaroli, L; Porazzi, P; Curtis, AT; Scopa, C; Mikkers, HM M; Freund, C; Daxinger, L; Deliard, S; Welsh, SA; Offley, S; et al. Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders. Nature Communications. 2021; 12:6469.

Bonatto Paese, CL; Hawkins, MB; Brugmann, SA; Harris, MP. Atavisms in the avian hindlimb and early developmental polarity of the limb. Developmental Dynamics. 2021; 250:1358-1367.

Chang, CF; Brown, KM; Yang, Y; Brugmann, SA. Centriolar Protein C2cd3 Is Required for Craniofacial Development. Frontiers in Cell and Developmental Biology. 2021; 9:647391.

Brugmann, S; Clouthier, DE; Saint-Jeannet, JP; Taneyhill, LA; Moody, SA. The society for craniofacial genetics and developmental biology 43rd annual meeting. American Journal of Medical Genetics, Part A. 2021; 185:1932-1939.

Brooks, EC; Paese, CL B; Carroll, AH; Struve, JN; Nagy, N; Brugmann, SA. Mutation in the Ciliary Protein C2CD3 Reveals Organ-Specific Mechanisms of Hedgehog Signal Transduction in Avian Embryos. Journal of Developmental Biology. 2021; 9:12.

Paese, CL B; Brooks, EC; Aarnio-Peterson, M; Brugmann, SA. Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling. Development (Cambridge). 2021; 148:dev194175.

2020

Elliott, KH; Chen, X; Salomone, J; Chaturvedi, P; Schultz, PA; Balchand, SK; Servetas, JD; Zuniga, A; Zeller, R; Gebelein, B; et al. Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks. eLife. 2020; 9:e56450.

2019

Elliott, KH; Brugmann, SA. Sending mixed signals: Cilia-dependent signaling during development and disease. Developmental Biology. 2019; 447:28-41.

Contact Us

Samantha Brugmann, PhD
Associate Director, Division of Developmental Biology
Director, Molecular & Developmental Biology Graduate Program
Member, Division of Plastic Surgery
Professor, UC Department of Pediatrics

Email: samantha.brugmann@cchmc.org
Office Phone: 513-636-1599
Lab Phone: 513-636-9798
Fax Number: 513-636-4317

In the News

Dr. Brugmann has been named a recipient of the Presidential Early Career Award for Scientists and Engineers (PECAS).

brugmann-visual1-500President Barack Obama joins recipients of the Presidential Early Career Award for Scientists and Engineers (PECASE) for a group photo in the East Room of the White House, May 5, 2016. (Official White House Photo by Lawrence Jackson). Dr. Brugmann was awarded the PECASE for her work on primary cilia in craniofacial development.

Click photo to enlarge & for caption.

Samantha Brugmann receives a Sustaining Outstanding Achievement in Research (SOAR) Grant from NIDCR. SOAR awards are geared towards supporting ambitious, long-term research of meritorious mid-career investigators.